R59949

[ Density]:
1.36g/cm3

[ Boiling Point ]:
637.1ºC at 760mmHg

[ Molecular Formula ]:
C₂₈H₂₅F₂N₃OS

[ Molecular Weight ]:
489.57900

[ Flash Point ]:
339.1ºC

[ Exact Mass ]:
489.16900

[ PSA ]:
73.12000

[ LogP ]:
5.87310

[ Vapour Pressure ]:
3.94E-16mmHg at 25°C

[ Index of Refraction ]:
1.688

[ Storage condition ]:
-20°C

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

Diacylglycerol kinase α promotes 3D cancer cell growth and limits drug sensitivity through functional interaction with Src.

Oncotarget 5(20) , 9710-26, (2014)

Diacylglycerol kinase (DGK)α converts diacylglycerol to phosphatidic acid. This lipid kinase sustains survival, migration and invasion of tumor cells, with no effect over untransformed cells, suggesti...

Insulin action on polyunsaturated phosphatidic acid formation in rat brain: an "in vitro" model with synaptic endings from cerebral cortex and hippocampus.

Neurochem. Res. 34(7) , 1236-48, (2009)

The highly efficient formation of phosphatidic acid from exogenous 1-stearoyl-2-arachidonoyl-sn-glycerol (SAG) in rat brain synaptic nerve endings (synaptosomes) from cerebral cortex and hippocampus i...

Effect of novel modulators of protein kinase C activity upon chemotherapy-induced differentiation and apoptosis in myeloid leukemic cells.

Anticancer Drugs 13(7) , 725-33, (2002)

Modulation of protein kinase C (PKC) activity has been demonstrated to either prevent or enhance drug-induced apoptosis in various tissue types. We tested four novel modulators of PKC activity in comp...

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