R59949
R59949 structure
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Common Name | R59949 | ||
|---|---|---|---|---|
| CAS Number | 120166-69-0 | Molecular Weight | 489.57900 | |
| Density | 1.36g/cm3 | Boiling Point | 637.1ºC at 760mmHg | |
| Molecular Formula | C28H25F2N3OS | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 339.1ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Diacylglycerol kinase α promotes 3D cancer cell growth and limits drug sensitivity through functional interaction with Src.
Oncotarget 5(20) , 9710-26, (2014) Diacylglycerol kinase (DGK)α converts diacylglycerol to phosphatidic acid. This lipid kinase sustains survival, migration and invasion of tumor cells, with no effect over untransformed cells, suggesting its potential as a cancer-specific target. Nonetheless t... |
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Insulin action on polyunsaturated phosphatidic acid formation in rat brain: an "in vitro" model with synaptic endings from cerebral cortex and hippocampus.
Neurochem. Res. 34(7) , 1236-48, (2009) The highly efficient formation of phosphatidic acid from exogenous 1-stearoyl-2-arachidonoyl-sn-glycerol (SAG) in rat brain synaptic nerve endings (synaptosomes) from cerebral cortex and hippocampus is reported. Phosphatidic acid synthesized from SAG or 1,2-d... |
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Effect of novel modulators of protein kinase C activity upon chemotherapy-induced differentiation and apoptosis in myeloid leukemic cells.
Anticancer Drugs 13(7) , 725-33, (2002) Modulation of protein kinase C (PKC) activity has been demonstrated to either prevent or enhance drug-induced apoptosis in various tissue types. We tested four novel modulators of PKC activity in comparison to the phorbol ester 12-O-tetradecanoylphorbol-13-ac... |
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Streptococcus mutans diacylglycerol kinase homologue: a potential target for anti-caries chemotherapy.
J. Med. Microbiol. 60(Pt 5) , 625-30, (2011) Aciduricity is a major cariogenic characteristic of Streptococcus mutans, and various genes have been implicated in this ability of S. mutans. Sixteen S. mutans mutant strains, each defective in a different gene, were constructed and their aciduricity was ass... |
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Evidence for the involvement of diacylglycerol kinase in the activation of hypoxia-inducible transcription factor 1 by low oxygen tension.
J. Biol. Chem. 276(13) , 10548-55, (2001) Hypoxia-inducible factor 1 (HIF-1) induces a gene expression program essential for the cellular adaptation to lowered oxygen environments. The intracellular mechanisms by which hypoxia induces HIF-1 remain poorly understood. Here we show that exposure of vari... |
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Involvement of diacylglycerol kinase γ in modulation of iNOS synthesis in Golgi apparatus of vascular endothelial cells.
Naunyn Schmiedebergs Arch. Pharmacol. 385(8) , 787-95, (2012) The aim of this study was to clarify the role of diacylglycerol kinase (DGK)γ in vascular endothelial cells. The mRNA and protein expression of DGKγ and inducible nitric oxide synthase (iNOS) in rat aortic endothelial cells (RAECs) were investigated using RT-... |
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Activation of human neutrophil NADPH oxidase by phosphatidic acid or diacylglycerol in a cell-free system. Activity of diacylglycerol is dependent on its conversion to phosphatidic acid.
J. Biol. Chem. 274(32) , 22243-50, (1999) The superoxide-generating neutrophil NADPH oxidase can be activated in cell-free reconstitution systems by several agonists, most notably arachidonic acid and the detergent sodium dodecyl sulfate. In this study, we show that both phosphatidic acids and diacyl... |
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Role of phospholipase D2/phosphatidic acid signal transduction in micro- and delta-opioid receptor endocytosis.
Mol. Pharmacol. 78(1) , 105-13, (2010) We demonstrated recently that opioid-induced activation of phospholipase D2 (PLD2) enhances mu- (MOPr) and delta-opioid receptor endocytosis/recycling and thus reduces the development of opioid receptor desensitization and tolerance. However, the mechanistic ... |
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Negative regulation of diacylglycerol kinase theta mediates adenosine-dependent hepatocyte preconditioning.
Cell Death Differ. 17(6) , 1059-68, (2010) In liver ischemic preconditioning (IP), stimulation of adenosine A2a receptors (A2aR) prevents ischemia/reperfusion injury by promoting diacylglycerol-mediated activation of protein kinase C (PKC). By concerting diacylglycerol to phosphatidic acid, diacylglyc... |
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Diacylglycerol kinase gamma serves as an upstream suppressor of Rac1 and lamellipodium formation.
J. Biol. Chem. 279(27) , 28603-13, (2004) Nine diacylglycerol kinase (DGK) isozymes have been identified. However, our knowledge of their individual functions is still limited. Here, we demonstrate the role of DGKgamma in regulating Rac1-governed cell morphology. We found that the expression of kinas... |