4-Chloro-3-sulfamoylbenzoic acid

Names

[ Name ]:
4-Chloro-3-sulfamoylbenzoic acid

[Synonym ]:
Benzoic acid, 3-(aminosulfonyl)-4-chloro-
EINECS 214-882-1
4-Chloro-3-sulfamoylbenzoic acid
MFCD00012375
3-(aminosulfonyl)-4-chlorobenzoic acid

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
502.4±60.0 °C at 760 mmHg

[ Melting Point ]:
256-258 °C(lit.)

[ Molecular Formula ]:
C₇H₆ClNO₄S

[ Molecular Weight ]:
235.645

[ Flash Point ]:
257.6±32.9 °C

[ Exact Mass ]:
234.970612

[ PSA ]:
105.84000

[ LogP ]:
0.92

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.622

[ Storage condition ]:
Refrigerator

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG5642600

CHEMICAL NAME :: Benzoic acid, 4-chloro-3-sulfamoyl-

CAS REGISTRY NUMBER :: 1205-30-7

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C7-H6-Cl-N-O4-S

MOLECULAR WEIGHT :: 235.65

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1100 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 16,2275,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 16,2275,1982

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DG5642600

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Sulclamide
4-Chloro-3-sulfamoylbenzoyl chloride
Alipamide
Indapamide
4-amino-3-sulfamoylbenzoic acid
4-chloro-3-(dimethylaminomethylideneamino)sulfonylbenzoic acid

Articles

Studies on metabolism of tripamide. III. Metabolic fate of 14C-tripamide in rats and rabbits.

Jpn. J. Pharmacol. 32(6) , 1041-9, (1982)

The metabolic fate of a new antihypertensive agent, tripamide (N-(4-aza-endo-tricyclo[5.2.1.0(2,6))]-decan-4-yl)-4-chloro-3-sulfamoylbenzamide), in rats and rabbits was studied using its 14C-labeled c...

Chromatographic-densitometric Method for Determination of Clopamide and 4-chlorobenzoic, and 4-chloro-3-sulfamoylbenzoic Acids in Tablets. Hubicka U, et al.

Curr. Pharm. Anal. 5(4) , 408-15, (2009)

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