4-Chloro-3-sulfamoylbenzoic acid

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Names

[ CAS No. ]:
1205-30-7

[ Name ]:
4-Chloro-3-sulfamoylbenzoic acid

[Synonym ]:
Benzoic acid, 3-(aminosulfonyl)-4-chloro-
EINECS 214-882-1
4-Chloro-3-sulfamoylbenzoic acid
MFCD00012375
3-(aminosulfonyl)-4-chlorobenzoic acid

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
502.4±60.0 °C at 760 mmHg

[ Melting Point ]:
256-258 °C(lit.)

[ Molecular Formula ]:
C7H6ClNO4S

[ Molecular Weight ]:
235.645

[ Flash Point ]:
257.6±32.9 °C

[ Exact Mass ]:
234.970612

[ PSA ]:
105.84000

[ LogP ]:
0.92

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.622

[ Storage condition ]:
Refrigerator

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DG5642600
CHEMICAL NAME :
Benzoic acid, 4-chloro-3-sulfamoyl-
CAS REGISTRY NUMBER :
1205-30-7
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C7-H6-Cl-N-O4-S
MOLECULAR WEIGHT :
235.65

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1100 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 16,2275,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 16,2275,1982

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DG5642600

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-Chlorobenzoic acid

DownStream

  • Sulclamide
  • 4-Chloro-3-sulfamoylbenzoyl chloride
  • Alipamide
  • Indapamide
  • 4-amino-3-sulfamoylbenzoic acid
  • 4-chloro-3-(dimethylaminomethylideneamino)sulfonylbenzoic acid

Articles

Studies on metabolism of tripamide. III. Metabolic fate of 14C-tripamide in rats and rabbits.

Jpn. J. Pharmacol. 32(6) , 1041-9, (1982)

The metabolic fate of a new antihypertensive agent, tripamide (N-(4-aza-endo-tricyclo[5.2.1.0(2,6))]-decan-4-yl)-4-chloro-3-sulfamoylbenzamide), in rats and rabbits was studied using its 14C-labeled c...

Chromatographic-densitometric Method for Determination of Clopamide and 4-chlorobenzoic, and 4-chloro-3-sulfamoylbenzoic Acids in Tablets. Hubicka U, et al.

Curr. Pharm. Anal. 5(4) , 408-15, (2009)


More Articles

Related Compounds

  • 4-chloro-3-sulfamoylbenzoic acid methyl ester
  • 4-Chloro-3-nitro-5-sulphamoylbenzoic acid
  • 4-chloro-2-nitro-3-sulfamoylbenzoic acid
  • 4-Chloro-3-nitrophenylacetic acid
  • Methyl 2-(4-chloro-3-nitrophenyl)acetate
  • 4-Chloro-3-fluorobenzoic acid
  • N-(3-(benzo[d]thiazol-2-yl)thiophen-2-yl)-1-(thiophen-2-ylsulfonyl)piperidine-4-carboxamide
  • 6-[(1S)-1-[8-Fluoro-6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-a]pyridin-3-yl]ethyl]-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one
  • 7-Chloro-5-(2-fluorophenyl)-1,4-benzodiazepin-2-one
  • Tert-butyl 2-(4-chlorophenyl)-3-(methylthio)-1,4,8-triazaspiro[4.5]deca-1,3-diene-8-carboxylate
  • Tert-butyl 2-(4-chlorophenyl)-3-thioxo-1,4,8-triazaspiro[4.5]dec-1-ene-8-carboxylate
  • 2-Methylsulfanyl-3-p-tolyl-1,4,8-triaza-spiro[4.5]deca-1,3-diene-8-carboxylic acid tert-butyl ester
  • Tert-butyl 2-(ethylthio)-3-(p-tolyl)-1,4,8-triazaspiro[4.5]deca-1,3-diene-8-carboxylate
  • 5-bromo-N4-isopropyl-6-methylpyrimidine-2,4-diamine
  • (3Z)-3-(anilinomethylene)-1-(3-methylbenzyl)-1H-2,1-benzothiazin-4(3H)-one 2,2-dioxide
  • (Z)-1-(3-methylbenzyl)-3-((o-tolylamino)methylene)-1H-benzo[c][1,2]thiazin-4(3H)-one 2,2-dioxide
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