Trimethyl phosphite

[ Density]:
1.052 g/mL at 25 °C(lit.)

[ Boiling Point ]:
110.2±8.0 °C at 760 mmHg

[ Melting Point ]:
−78 °C(lit.)

[ Molecular Formula ]:
C₃H₉O₃P

[ Molecular Weight ]:
124.076

[ Flash Point ]:
27.8±0.0 °C

[ Exact Mass ]:
124.028931

[ PSA ]:
41.28000

[ LogP ]:
-0.93

[ Vapour density ]:
4.3 (vs air)

[ Vapour Pressure ]:
28.1±0.2 mmHg at 25°C

[ Index of Refraction ]:
n20/D 1.408(lit.)

Click to get detail MSDS

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TH1400000

CHEMICAL NAME :: Phosphorous acid, trimethyl ester

CAS REGISTRY NUMBER :: 121-45-9

LAST UPDATED :: 199712

DATA ITEMS CITED :: 29

MOLECULAR FORMULA :: C3-H9-O3-P

MOLECULAR WEIGHT :: 124.09

WISWESSER LINE NOTATION :: 1OPO1&O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,609,1969

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Mammal - species unspecified

REFERENCE :: MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950- Volume(issue)/page/year: 29,393,1978

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Mammal - species unspecified

REFERENCE :: MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950- Volume(issue)/page/year: 29,393,1978 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ALBRW* Albright & Wilson Inc. (P.O. Box 26229, Richmond, VA 23260-6229) Volume(issue)/page/year: #OPB-3,1984

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10000 ppm/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 34,286,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 9,1,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 34,286,1973 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 ppm/7.5H/8W-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - emphysema Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) Skin and Appendages - hair

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 34,286,1973 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1640 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 72,119,1984

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1640 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 72,119,1984 *** REVIEWS *** ACGIH TLV-TWA 10 mg/m3 (2 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 2 ppm (10 mg/m3) JAN 1993 OEL-BELGIUM:TWA 2 ppm (10 mg/m3) JAN 1993 OEL-DENMARK:TWA 0.5 ppm (2.6 mg/m3) JAN 1993 OEL-FINLAND:TWA 0.5 ppm (2.6 mg/m3);STEL 10 ppm (52 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 2 ppm (10 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 2 ppm (10 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 2 ppm (10 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 2 ppm (10 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO TRIMETHYL PHOSPHITE-air:10H TWA 2 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84215 No. of Facilities: 260 (estimated) No. of Industries: 5 No. of Occupations: 7 No. of Employees: 1891 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84215 No. of Facilities: 55 (estimated) No. of Industries: 2 No. of Occupations: 18 No. of Employees: 14190 (estimated) No. of Female Employees: 6312 (estimated)

[ Symbol ]:

GHS02, GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H226-H302-H315-H318-H335

[ Supplemental HS ]:
Reacts violently with water.

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R10;R22;R36/37/38

[ Safety Phrases ]:
S26

[ RIDADR ]:
UN 2329 3/PG 3

[ WGK Germany ]:
1

[ RTECS ]:
TH1400000

[ Packaging Group ]:
III

[ Hazard Class ]:
3

[ HS Code ]:
2920901100

Click to get detail synthetic route

Precursor

Methanol
pentacarbonyl(trimethylphosphite)chromium(0)
Tetraphosphorus nonoxide
tetraphosphorus octaoxide
tris(4-dimethylaminopyridine)phosphorus(3+) bromide
lithium,methoxyethyne
DIMETHYLCHLOROPHOSPHITE
Sodium Methylate
Dimethyl phosphonate
4',4'-dimethyl-2λ5-spiro[benzo[1,3,2]dioxaphosphole-2,2'-[1,3,2]oxazaphospholidin]-5'-one

DownStream

(1-chloropropylideneamino) dimethyl phosphate
Phosphonic acid,P-(4-methoxybenzoyl)-, dimethyl ester
2-chloro-4-dimethoxyphosphoryl-6-methoxy-1,3,5-triazine
11-(2,5-dimethyl-11-bicyclo[4.4.1]undeca-3,7,9-trienyl)-2,5-dimethylbicyclo[4.4.1]undeca-3,7,9-triene
Dichlorvos
Metrifonate
2,2-dichloroethenyl methyl hydrogen phosphate
Methanol
4-methoxyphenylphosphonic acid diethyl ester

[ HS Code ]: 2920901100

[ Summary ]:
2920901100 trimethyl phosphite。supervision conditions:23(import license for dual-use item and technologies,export license for dual-use item and technologies)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%

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