Trimethyl phosphite
Suppliers
Names
[ CAS No. ]:
121-45-9
[ Name ]:
Trimethyl phosphite
[Synonym ]:
Methyl phosphite (P(OMe)3
dimethyl methylphosphonate
Trimethylfosfit
Trimethylphosphite
Methyl phosphite
Trimethyl phosphite
Fosforyn trojmetylowy
MFCD00008350
EINECS 204-471-5
Trimethoxyphosphine
Phosphorous acid, trimethyl ester
phosphorous acid trimethyl ester
Chemical & Physical Properties
[ Density]:
1.052 g/mL at 25 °C(lit.)
[ Boiling Point ]:
110.2±8.0 °C at 760 mmHg
[ Melting Point ]:
−78 °C(lit.)
[ Molecular Formula ]:
C3H9O3P
[ Molecular Weight ]:
124.076
[ Flash Point ]:
27.8±0.0 °C
[ Exact Mass ]:
124.028931
[ PSA ]:
41.28000
[ LogP ]:
-0.93
[ Vapour density ]:
4.3 (vs air)
[ Vapour Pressure ]:
28.1±0.2 mmHg at 25°C
[ Index of Refraction ]:
n20/D 1.408(lit.)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TH1400000
- CHEMICAL NAME :
- Phosphorous acid, trimethyl ester
- CAS REGISTRY NUMBER :
- 121-45-9
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 29
- MOLECULAR FORMULA :
- C3-H9-O3-P
- MOLECULAR WEIGHT :
- 124.09
- WISWESSER LINE NOTATION :
- 1OPO1&O1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- 34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,609,1969
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Mammal - species unspecified
- REFERENCE :
- MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950- Volume(issue)/page/year: 29,393,1978
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Mammal - species unspecified
- REFERENCE :
- MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950- Volume(issue)/page/year: 29,393,1978 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1600 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ALBRW* Albright & Wilson Inc. (P.O. Box 26229, Richmond, VA 23260-6229) Volume(issue)/page/year: #OPB-3,1984
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >10000 ppm/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 34,286,1973
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4180 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 9,1,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 2600 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 34,286,1973 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 ppm/7.5H/8W-I
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - emphysema Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) Skin and Appendages - hair
- REFERENCE :
- AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 34,286,1973 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1640 mg/kg
- SEX/DURATION :
- female 6-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 72,119,1984
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1640 mg/kg
- SEX/DURATION :
- female 6-15 day(s) after conception
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 72,119,1984 *** REVIEWS *** ACGIH TLV-TWA 10 mg/m3 (2 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 2 ppm (10 mg/m3) JAN 1993 OEL-BELGIUM:TWA 2 ppm (10 mg/m3) JAN 1993 OEL-DENMARK:TWA 0.5 ppm (2.6 mg/m3) JAN 1993 OEL-FINLAND:TWA 0.5 ppm (2.6 mg/m3);STEL 10 ppm (52 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 2 ppm (10 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 2 ppm (10 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 2 ppm (10 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 2 ppm (10 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO TRIMETHYL PHOSPHITE-air:10H TWA 2 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84215 No. of Facilities: 260 (estimated) No. of Industries: 5 No. of Occupations: 7 No. of Employees: 1891 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84215 No. of Facilities: 55 (estimated) No. of Industries: 2 No. of Occupations: 18 No. of Employees: 14190 (estimated) No. of Female Employees: 6312 (estimated)
Safety Information
[ Symbol ]:
GHS02, GHS05, GHS07
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H226-H302-H315-H318-H335
[ Supplemental HS ]:
Reacts violently with water.
[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xn:Harmful;
[ Risk Phrases ]:
R10;R22;R36/37/38
[ Safety Phrases ]:
S26
[ RIDADR ]:
UN 2329 3/PG 3
[ WGK Germany ]:
1
[ RTECS ]:
TH1400000
[ Packaging Group ]:
III
[ Hazard Class ]:
3
[ HS Code ]:
2920901100
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2920901100
[ Summary ]:
2920901100 trimethyl phosphite。supervision conditions:23(import license for dual-use item and technologies,export license for dual-use item and technologies)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%
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