Trimethyl phosphite

Modify Date: 2026-06-30 12:46:35

Trimethyl phosphite Structure
Trimethyl phosphite structure
 Common Name Trimethyl phosphite
CAS Number 121-45-9 Molecular Weight 124.076
Density 1.052 g/mL at 25 °C(lit.) Boiling Point 110.2±8.0 °C at 760 mmHg
Molecular Formula C3H9O3P Melting Point −78 °C(lit.)
MSDS Chinese USA Flash Point 27.8±0.0 °C
Symbol GHS02 GHS05 GHS07
GHS02, GHS05, GHS07		 Signal Word Danger

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name Trimethyl phosphite
Synonym More Synonyms

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.052 g/mL at 25 °C(lit.)
Boiling Point 110.2±8.0 °C at 760 mmHg
Melting Point −78 °C(lit.)
Molecular Formula C3H9O3P
Molecular Weight 124.076
Flash Point 27.8±0.0 °C
Exact Mass 124.028931
PSA 41.28000
LogP -0.93
Vapour density 4.3 (vs air)
Vapour Pressure 28.1±0.2 mmHg at 25°C
Index of Refraction n20/D 1.408(lit.)
InChIKey CYTQBVOFDCPGCX-UHFFFAOYSA-N
SMILES COP(OC)OC

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TH1400000
CHEMICAL NAME :
Phosphorous acid, trimethyl ester
CAS REGISTRY NUMBER :
121-45-9
LAST UPDATED :
199712
DATA ITEMS CITED :
29
MOLECULAR FORMULA :
C3-H9-O3-P
MOLECULAR WEIGHT :
124.09
WISWESSER LINE NOTATION :
1OPO1&O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,609,1969
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Mammal - species unspecified
REFERENCE :
MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950- Volume(issue)/page/year: 29,393,1978
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Mammal - species unspecified
REFERENCE :
MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950- Volume(issue)/page/year: 29,393,1978 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ALBRW* Albright & Wilson Inc. (P.O. Box 26229, Richmond, VA 23260-6229) Volume(issue)/page/year: #OPB-3,1984
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>10000 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 34,286,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 9,1,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
2600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 34,286,1973 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
500 ppm/7.5H/8W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - emphysema Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) Skin and Appendages - hair
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 34,286,1973 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1640 mg/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 72,119,1984
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1640 mg/kg
SEX/DURATION :
female 6-15 day(s) after conception
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 72,119,1984 *** REVIEWS *** ACGIH TLV-TWA 10 mg/m3 (2 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 2 ppm (10 mg/m3) JAN 1993 OEL-BELGIUM:TWA 2 ppm (10 mg/m3) JAN 1993 OEL-DENMARK:TWA 0.5 ppm (2.6 mg/m3) JAN 1993 OEL-FINLAND:TWA 0.5 ppm (2.6 mg/m3);STEL 10 ppm (52 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 2 ppm (10 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 2 ppm (10 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 2 ppm (10 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 2 ppm (10 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO TRIMETHYL PHOSPHITE-air:10H TWA 2 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84215 No. of Facilities: 260 (estimated) No. of Industries: 5 No. of Occupations: 7 No. of Employees: 1891 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84215 No. of Facilities: 55 (estimated) No. of Industries: 2 No. of Occupations: 18 No. of Employees: 14190 (estimated) No. of Female Employees: 6312 (estimated)

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol GHS02 GHS05 GHS07
GHS02, GHS05, GHS07
Signal Word Danger
Hazard Statements H226-H302-H315-H318-H335
Supplemental HS Reacts violently with water.
Precautionary Statements P261-P280-P305 + P351 + P338
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xn:Harmful;
Risk Phrases R10;R22;R36/37/38
Safety Phrases S26
RIDADR UN 2329 3/PG 3
WGK Germany 1
RTECS TH1400000
Packaging Group III
Hazard Class 3
HS Code 2920901100

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2920901100
Summary 2920901100 trimethyl phosphite。supervision conditions:23(import license for dual-use item and technologies,export license for dual-use item and technologies)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%

 Articles10

More Articles

This table lists relevant public references with title, journal and publication metadata for this compound.

Interactions of multitargeted kinase inhibitors and nucleoside drugs: Achilles heel of combination therapy?

J. Chromatogr. A. 1421 , 154-61, (2015)

Multitargeted tyrosine kinase inhibitors (TKI) axitinib, pazopanib, and sunitinib are used to treat many solid tumors. Combination trials of TKIs with gemcitabine, a nucleoside anticancer drug, in pan...

Rapid modification of the insect elicitor N-linolenoyl-glutamate via a lipoxygenase-mediated mechanism on Nicotiana attenuata leaves.

BMC Plant Biol. 10 , 164, (2010)

Some plants distinguish mechanical wounding from herbivore attack by recognizing specific constituents of larval oral secretions (OS) which are introduced into plant wounds during feeding. Fatty acid-...

The functionalisation of saturated hydrocarbons--XXX. Model studies on the mechanism of some oxygenases.

Bioorg. Med. Chem. 2(4) , 259-66, (1994)

In harmony with our studies on the activation of hydrocarbons by Gif chemistry, we have, in the first part of this paper, studied the mechanism of the lipoxygenase enzymes using soybean lipoxygenase a...

 Trimethyl phosphiteBioassay

View more

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273
Name: qHTS assay to identify small molecule antagonists of the peroxisome proliferator-acti...
Source: 824
Target: N/A
External Id: PPARGV841
Name: qHTS assay to identify small molecule agonists of the TGF-beta/Smad signaling pathway...
Source: 824
Target: N/A
External Id: TGF788
Name: qHTS assay to identify small molecule antagonists of the TGF-beta/Smad signaling path...
Source: 824
Target: N/A
External Id: TGF602
Name: qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cell fr...
Source: 824
Target: N/A
External Id: SPEC167MG
Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600
Name: qHTS assay to identify small molecule agonists of the peroxisome proliferator-activat...
Source: 824
Target: N/A
External Id: PPARDV813
Name: qHTS assay to test for compound auto fluorescence at 590 nm (red) in HEK293 cell free...
Source: 824
Target: N/A
External Id: SPEC167MR
Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958
Name: qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cells
Source: 824
Target: N/A
External Id: SPEC167CG
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 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Methyl phosphite (P(OMe)3
dimethyl methylphosphonate
Trimethylfosfit
Trimethylphosphite
Methyl phosphite
Trimethyl phosphite
Fosforyn trojmetylowy
MFCD00008350
EINECS 204-471-5
Trimethoxyphosphine
Phosphorous acid, trimethyl ester
phosphorous acid trimethyl ester

 Trimethyl phosphite | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the polar surface area (PSA) of Trimethyl phosphite?
A: Polar surface area (PSA) of Trimethyl phosphite is 41.28000.
Q: What is the molecular weight of Trimethyl phosphite?
A: Molecular weight of Trimethyl phosphite is 124.076.
Q: What is the English name of Trimethyl phosphite?
A: The English name of Trimethyl phosphite is Trimethyl phosphite.
Q: What are the upstream materials of Trimethyl phosphite?
A: Related upstream materials(CAS) of Trimethyl phosphite: 67-56-1;18461-34-2;12037-11-5;70983-17-4;139111-73-2;36677-82-4;3743-07-5;124-41-4;868-85-9;51145-42-7.
Q: What is the LogP of Trimethyl phosphite?
A: LogP of Trimethyl phosphite is -0.93.
Q: What is the molecular formula of Trimethyl phosphite?
A: Molecular formula of Trimethyl phosphite is C3H9O3P.
Q: What is the boiling point of Trimethyl phosphite?
A: Boiling point of Trimethyl phosphite is 110.2±8.0 °C at 760 mmHg.
Q: What is the melting point of Trimethyl phosphite?
A: Melting point of Trimethyl phosphite is −78 °C(lit.).
Q: What are the downstream products of Trimethyl phosphite?
A: Related downstream products(CAS) of Trimethyl phosphite: 111737-71-4;10570-48-6;106052-30-6;110447-65-9;62-73-7;52-68-6;13445-62-0;67-56-1;3762-33-2.
Q: What English synonyms does Trimethyl phosphite have?
A: English synonyms of Trimethyl phosphite: Methyl phosphite (P(OMe)3, dimethyl methylphosphonate, Trimethylfosfit, Trimethylphosphite, Methyl phosphite, Trimethyl phosphite, Fosforyn trojmetylowy, MFCD00008350, EINECS 204-471-5, Trimethoxyphosphine, Phosphorous acid, trimethyl ester, phosphorous acid trimethyl ester.

 Trimethyl phosphitefactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Henan Tianfu Chemical Co., Ltd.
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Chemsrc provides Trimethyl phosphite(CAS#:121-45-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Trimethyl phosphite are included as well.>> amp version: Trimethyl phosphite

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