5-Nitrothiazol-2-amine

Names

[ CAS No. ]:
121-66-4

[ Name ]:
5-Nitrothiazol-2-amine

[Synonym ]:
2-Amino-5-nitrothiazole
2-Thiazolamine, 5-nitro-
5-nitro-2-thiazolylamin
5-Nitrothiazol-2-amine
5-Nitro-1,3-thiazol-2-amine
MFCD00005326
EINECS 204-490-9
2-AMINO-5-NITRO THIAZOLE

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
345.1±15.0 °C at 760 mmHg

[ Melting Point ]:
195-200 °C (dec.)(lit.)

[ Molecular Formula ]:
C₃H₃N₃O₂S

[ Molecular Weight ]:
145.140

[ Flash Point ]:
162.5±20.4 °C

[ Exact Mass ]:
144.994598

[ PSA ]:
112.97000

[ LogP ]:
0.83

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.705

[ Stability ]:
Stable. Incompatible with strong acids, strong oxidizing agents, acid chlorides, acid anhydrides.

[ Water Solubility ]:
<0.1 g/100 mL at 20 ºC

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XJ2800000

CHEMICAL NAME :: Thiazole, 2-amino-5-nitro-

CAS REGISTRY NUMBER :: 121-66-4

BEILSTEIN REFERENCE NO. :: 0126797

LAST UPDATED :: 199710

DATA ITEMS CITED :: 24

MOLECULAR FORMULA :: C3-H3-N3-O2-S

MOLECULAR WEIGHT :: 145.15

WISWESSER LINE NOTATION :: T5N CSJ BZ DNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 28 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Blood - leukemia Blood - lymphoma, including Hodgkin's disease

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 23 gm/kg/46W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors Skin and Appendages - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 12 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Reproductive - Tumorigenic effects - uterine tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 600 mg/kg

SEX/DURATION :: male 10 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 700 mg/kg

SEX/DURATION :: male 14 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - menstrual cycle changes or disorders

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - mouse Lymphocyte

DOSE/DURATION :: 15600 ug/L

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 12(Suppl 13),103,1988 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 31,71,1983 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 31,71,1983 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P301 + P312 + P330-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R20/21/22;R40

[ Safety Phrases ]:
S26-S45-S24/25

[ RIDADR ]:
2811

[ WGK Germany ]:
3

[ RTECS ]:
XJ2800000

[ HS Code ]:
2934100090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Pentanamide,N-(5-nitro-2-thiazolyl)-
1H-Isoindole-1,3(2H)-dione,4-nitro-2-(5-nitro-2-thiazolyl)-
2-CHLORO-5-NITROTHIAZOLE
2-Bromo-5-nitrothiazole
Nitazoxanide
2-(5-nitro-thiazol-2-yl)-3a,4,7,7a-tetrahydro-4,7-methano-isoindole-1,3-dione
4-fluoro-N-(5-nitro-1,3-thiazol-2-yl)benzamide
2-Bromo-N-(5-nitrothiazol-2-yl)acetamide
1-(2-chloroethyl)-3-(5-nitro-1,3-thiazol-2-yl)urea
5-nitro-1,3-thiazole

Customs

[ HS Code ]: 2934100090

[ Summary ]:
2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Articles

Evaluation of 2-amino-5-nitrothiazole as a hypoxic cell radiosensitizer.

Radiat. Res. 90(3) , 575-85, (1982)

Platinum complexes with one radiosensitizing ligand [PtCl2(NH3) (sensitizer)]: radiosensitization and toxicity studies in vitro.

Radiat. Res. 112(2) , 273-82, (1987)

Complexes of general formula [PtCl2(NH3)L] with one radiosensitizing ligand per platinum are compared with ligand L alone, complexes with two radiosensitizers per platinum [PtCl2L2], and their analogs...

2-amino-5-nitrothiazole.

IARC Monogr. Eval. Carcinog. Risk Chem. Hum. 31 , 71-7, (1983)

SU3327
4-nitro-1,3-thiazol-2-amine
N-methyl-5-nitro-1,3-thiazol-2-amine
N-(5-nitrothiazol-2-yl)furan-2-carboxamide
N-[2-[(5-nitrothiazol-2-yl)azo]-5-[(phenylsulphonyl)amino]phenyl]acetamide
[[5-acetamido-4-[(5-nitrothiazol-2-yl)azo]-2-methoxyphenyl]imino]diethyl dipropionate