5-Benzyloxyindole

Suppliers

Names

[ Name ]:
5-Benzyloxyindole

[Synonym ]:
5-Benzyloxyindole
1H-Indole, 5- (phenylmethoxy)-
5-(Benzyloxy)indole
1H-Indole, 5-(phenylmethoxy)-
5-Benzyindole
Indole, 5- (benzyloxy)-
5-benzyloxy-indol
Benzyloxy-5 indole
5-phenylmethoxyindole
bredreck's
EINECS 214-930-1
5-(Benzyloxy)-1H-indole
5-phenylmethoxy-1H-indole
5-BnO-indole
5-BENZYLOXY-1H-INDOLE
MFCD00005676

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
411.6±20.0 °C at 760 mmHg

[ Melting Point ]:
100-104 °C(lit.)

[ Molecular Formula ]:
C₁₅H₁₃NO

[ Molecular Weight ]:
223.270

[ Flash Point ]:
148.9±12.0 °C

[ Exact Mass ]:
223.099716

[ PSA ]:
25.02000

[ LogP ]:
3.71

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.670

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
ethanol: may be hazy yellow

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NL4850000

CHEMICAL NAME :: Indole, 5-benzyloxy-

CAS REGISTRY NUMBER :: 1215-59-4

BEILSTEIN REFERENCE NO. :: 0173532

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C15-H13-N-O

MOLECULAR WEIGHT :: 223.29

WISWESSER LINE NOTATION :: T56 BMJ GO1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 9,453,1974

Safety Information

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S24/25-S22

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
NL4850000

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

1-[2-(5-Benzyloxy-2-nitrophenyl)vinyl]pyrrolidine
5-Indolol
Benzyl bromide
5-(Benzyloxy)-1H-indole-2-carboxylic acid
1-benzyl-5-(benzyloxy)-1H-indole
trans-5-benzyloxy-β-(dimethylamino)-2-nitrostyrene
HA 01-0196
1-(2-amino-5-phenylmethoxyphenyl)-2-chloroethanone
Benzyl chloride

DownStream

5-Hydroxytryptamine
5-Hydroxy-1H-indole-3-carboxylic acid
5-benzyloxyindole-3-acetic acid
1H-Indole-3-acetamide,5-(phenylmethoxy)-
ethyl 3-(5-hydroxyindol-1-yl)propanoate
5-phenylmethoxy-1-(pyridin-4-ylmethyl)indole
5-phenylmethoxyindol-1-amine
1-benzylindol-5-ol
3-methyl-5-phenylmethoxy-1H-indole
Tryptophan,5-(phenylmethoxy)-

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

5-benzyloxytryptamine as an antagonist of TRPM8.

Bioorg. Med. Chem. Lett. 20 , 7076-9, (2010)

5-Benzyloxytryptamine 19 was found to act as an antagonist of the TRPM8 ion-channel. For example, 19 had an IC(50) of 0.34 μM when menthol was used as the stimulating agonist. Related commercially-ava...