4-hydroxybenzaldehyde

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Names

[ CAS No. ]:
123-08-0

[ Name ]:
4-hydroxybenzaldehyde

[Synonym ]:
p-Hydroxybenzaldehyde
MFCD00006939
4-Hydroxy benzaldehyde
4-Hydroxybenzaldehyde
EINECS 204-599-1
Bisoprolol Impurity 15

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
246.6±13.0 °C at 760 mmHg

[ Melting Point ]:
112-116 °C(lit.)

[ Molecular Formula ]:
C7H6O2

[ Molecular Weight ]:
122.121

[ Flash Point ]:
101.3±12.4 °C

[ Exact Mass ]:
122.036781

[ PSA ]:
37.30000

[ LogP ]:
1.39

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.618

[ Storage condition ]:
Store at 2-8°C

[ Water Solubility ]:
13 g/L (30 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CU6475000
CHEMICAL NAME :
Benzaldehyde, p-hydroxy-
CAS REGISTRY NUMBER :
123-08-0
BEILSTEIN REFERENCE NO. :
0471352
LAST UPDATED :
199710
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C7-H6-O2
MOLECULAR WEIGHT :
122.13
WISWESSER LINE NOTATION :
VHR DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3980 mg/kg
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions Behavioral - tremor Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Human Lymphocyte
DOSE/DURATION :
1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 206,17,1988

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
CU6475000

[ Packaging Group ]:
I; II; III

[ HS Code ]:
2912210000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-Methoxybenzaldehyde
  • Methanediol,1-[4-(acetyloxy)phenyl]-, 1,1-diacetate
  • Benzaldehyde, 4-hydroxy-, oxime
  • 1,1-diacetoxy-1-(4-hydroxyphenyl)methane
  • 4-(1,3-Dithian-2-yl)phenol
  • 4-Iodobenzaldehyde
  • 4-Hydroxybenzyl alcohol
  • 4-Hydroxyphenylacetic acid
  • 4-allyloxybenzaldehyde
  • 4-Formylphenylboronic acid

DownStream

  • N-[(E)-1-(4-aminophenyl)ethylideneamino]-2-[4-[(Z)-(3-methyl-5-oxo-1H-pyrazol-4-ylidene)methyl]phenoxy]acetamide
  • BENZOIC ACID, 2-[(4-FORMYLPHENOXY)METHYL]-, METHYL ESTER
  • methyl 11-(4-ethenylphenoxy)undecanoate
  • 4-but-3-enoxybenzaldehyde
  • 2-[4-[(Z)-(3-methyl-5-oxo-1H-pyrazol-4-ylidene)methyl]phenoxy]-N-[(3-n itrophenyl)methylideneamino]acetamide
  • 4-(4-hexylbenzoyl)oxybenzoic acid
  • 5-hydroxy-3-[(4-hydroxyphenyl)methylidene]-1-benzofuran-2-one
  • 5-Hydroxy-3-[(4-hydroxyphenyl)methylene]benzofuran-2(3H)-one
  • 2-[4-[(Z)-(3-methyl-5-oxo-1H-pyrazol-4-ylidene)methyl]phenoxy]-N-[(E)-1-phenylethylideneamino]acetamide
  • N-[(E)-(3,4-dimethoxyphenyl)methylideneamino]-2-[4-[(Z)-(3-methyl-5-oxo-1H-pyrazol-4-ylidene)methyl]phenoxy]acetamide

Customs

[ HS Code ]: 2912499000

[ Summary ]:
2912499000. other aldehyde-ethers, aldehyde-phenols and aldehydes with other oxygen function. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

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Related Compounds

  • 4-hydroxybenzaldehyde
  • 4-Hydroxybenzaldehyde-d6
  • 4-hydroxybenzaldehyde oxime
  • 4-HYDROXYBENZALDEHYDE OXIME
  • 4-hydroxybenzaldehyde azine
  • 3-Iodo-4-hydroxybenzaldehyde
  • 3-Methyl-2-(methylamino)-2,4,5,6-tetrahydrocyclopenta[c]pyrrole-1-carboxylic acid
  • N-[(1S)-1-cyanoethyl]-2-fluoro-4-methoxybenzamide
  • (6-Methoxy-3-methylpyridin-2-yl)methanamine
  • (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(3,3-difluorocyclobutyl)acetic acid
  • 2-Ethenyloxolan-3-amine hydrochloride
  • 2-chloro-7H-pyrrolo[2,3-d]pyrimidine-6-carbaldehyde
  • 3-(Difluoromethyl)bicyclo[1.1.1]pentan-1-amine
  • Benzyl 4-(chlorosulfonyl)-2,3-dihydro-1H-indole-1-carboxylate
  • N-(Cyanomethyl)-2-(7-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)acetamide
  • 2-(Difluoromethyl)-4H,6H,7H,8H,9H-pyrido[1,2-a]pyrimidin-4-one