4-hydroxybenzaldehyde

Modify Date: 2025-08-20 06:08:49

4-hydroxybenzaldehyde structure	Common Name	4-hydroxybenzaldehyde
	CAS Number	123-08-0	Molecular Weight	122.121
	Density	1.2±0.1 g/cm3	Boiling Point	246.6±13.0 °C at 760 mmHg
	Molecular Formula	C₇H₆O₂	Melting Point	112-116 °C(lit.)
	MSDS	Chinese USA	Flash Point	101.3±12.4 °C
	Symbol	GHS07	Signal Word	Warning

Use of 4-hydroxybenzaldehyde

p-Hydroxybenzaldehyde is a one of the major components in Dendrocalamus asper bamboo shoots, with antagonistic effect on GABAA receptor of the α1β2γ2S subtype at high concentrations.

Name	4-hydroxybenzaldehyde
Synonym	More Synonyms

Description	p-Hydroxybenzaldehyde is a one of the major components in Dendrocalamus asper bamboo shoots, with antagonistic effect on GABAA receptor of the α1β2γ2S subtype at high concentrations.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Natural Products >> Acids and Aldehydes Research Areas >> Neurological Disease
Target	Human Endogenous Metabolite
In Vitro	p-Hydroxybenzaldehyde (4-hydroxybenzaldehyde) is a one of the major components in Dendrocalamus asper bamboo shoots, with antagonistic effect on GABAA receptor of the α1β2γ2S subtype at high concentrations. p-Hydroxybenzaldehyde (101.7 μM) significantly reduces the GABA-induced chloride current of GABAA receptors expressed on Xenopus oocytes[1].
References	[1]. Zhang J, et al. The Effect of 4-hydroxybenzaldehyde on the γ-aminobutyric Acid Type A Receptor. Malays J Med Sci. 2017 Mar;24(2):94-99.

Density	1.2±0.1 g/cm3
Boiling Point	246.6±13.0 °C at 760 mmHg
Melting Point	112-116 °C(lit.)
Molecular Formula	C₇H₆O₂
Molecular Weight	122.121
Flash Point	101.3±12.4 °C
Exact Mass	122.036781
PSA	37.30000
LogP	1.39
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.618
Storage condition	Store at 2-8°C
Water Solubility	13 g/L (30 ºC)

4-hydroxybenzaldehyde MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CU6475000

CHEMICAL NAME :: Benzaldehyde, p-hydroxy-

CAS REGISTRY NUMBER :: 123-08-0

BEILSTEIN REFERENCE NO. :: 0471352

LAST UPDATED :: 199710

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C7-H6-O2

MOLECULAR WEIGHT :: 122.13

WISWESSER LINE NOTATION :: VHR DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3980 mg/kg

TOXIC EFFECTS :: Behavioral - hallucinations, distorted perceptions Behavioral - tremor Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 1 mmol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 206,17,1988

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S36-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	CU6475000
Packaging Group	I; II; III
HS Code	2912210000

Precursor 10
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DownStream 10
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HS Code	2912499000
Summary	2912499000. other aldehyde-ethers, aldehyde-phenols and aldehydes with other oxygen function. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

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p-Hydroxybenzaldehyde

MFCD00006939

4-Hydroxy benzaldehyde

4-Hydroxybenzaldehyde

EINECS 204-599-1

Bisoprolol Impurity 15

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Price: ￥550/10 mM * 1 mL in DMSO

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4-hydroxybenzaldehyde

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