N-methylformamide
Names
[ CAS No. ]:
123-39-7
        
[ Name ]:
 N-methylformamide
        
[Synonym ]:
                
                N-Methylformamid
                
                
            
                
                methanimidic acid, methyl-
                
                
            
                
                METHYLFORMAMIDE
                
                
            
                
                formamide, methyl-
                
                
            
                
                ek7011
                
                
            
                
                X 188
                
                
            
                
                METHYL FORMAMIDE
                
                
            
                
                HCONHCH3
                
                
            
                
                N-methyl-carboxamide
                
                
            
                
                4-04-00-00170 (Beilstein Handbook Reference)
                
                
            
                
                Formamide, N-methyl- (8CI 9CI)
                
                
            
                
                Formamide, N-methyl-
                
                
            
                
                N-METHYL-FORMAMIDE
                
                
            
                
                Ethanamide
                
                
            
                
                N-METHYLFORMAMIDE/N-FORMYLMETHYLAMINE
                
                
            
                
                N-Formylmethylamine
                
                
            
                
                N-Methylformamide
                
                
            
                
                Acetamide
                
                
            
                
                Formylmethylamine
                
                
            
                
                N-METHYL FORMAMIDE
                
                
            
                
                n-methyl-formamid
                
                
            
                
                monomethylformamide
                
                
            
                
                Methylcarbylamine
                
                
            
                
                monomethyl-formamide
                
                
            
                
                MFCD00003280
                
                
            
                
                EINECS 204-624-6
                
                
                
                
    
Chemical & Physical Properties
[ Density]:
1.011
            
[ Boiling Point ]:
199-201 ºC
            
[ Melting Point ]:
-4 ºC
            
[ Molecular Formula ]:
C2H5NO
            
[ Molecular Weight ]:
59.067
            
[ Flash Point ]:
111 ºC
            
[ Exact Mass ]:
59.037113
            
[ PSA ]:
29.10000
            
[ LogP ]:
-0.60
            
[ Vapour Pressure ]:
0.8±0.3 mmHg at 25°C
            
[ Index of Refraction ]:
1.431-1.433
            
[ Water Solubility ]:
miscible
            
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
 - LQ3000000
 
- CHEMICAL NAME :
 - Formamide, N-methyl-
 
- CAS REGISTRY NUMBER :
 - 123-39-7
 
- BEILSTEIN REFERENCE NO. :
 - 1098352
 
- LAST UPDATED :
 - 199712
 
- DATA ITEMS CITED :
 - 40
 
- MOLECULAR FORMULA :
 - C2-H5-N-O
 
- MOLECULAR WEIGHT :
 - 59.08
 
- WISWESSER LINE NOTATION :
 - VHM1
 
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
 - Standard Draize test
 
- ROUTE OF EXPOSURE :
 - Administration into the eye
 
- SPECIES OBSERVED :
 - Rodent - rabbit
 
- REFERENCE :
 - TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 39,129,1977 ** ACUTE TOXICITY DATA **
 
- TYPE OF TEST :
 - LD50 - Lethal dose, 50 percent kill
 
- ROUTE OF EXPOSURE :
 - Oral
 
- SPECIES OBSERVED :
 - Rodent - rat
 
- DOSE/DURATION :
 - 4 gm/kg
 
- TOXIC EFFECTS :
 - Details of toxic effects not reported other than lethal dose value
 
- REFERENCE :
 - JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 4,219,1962
 
- TYPE OF TEST :
 - LD50 - Lethal dose, 50 percent kill
 
- ROUTE OF EXPOSURE :
 - Intraperitoneal
 
- SPECIES OBSERVED :
 - Rodent - rat
 
- DOSE/DURATION :
 - 3500 mg/kg
 
- TOXIC EFFECTS :
 - Details of toxic effects not reported other than lethal dose value
 
- REFERENCE :
 - JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 4,219,1962
 
- TYPE OF TEST :
 - LD50 - Lethal dose, 50 percent kill
 
- ROUTE OF EXPOSURE :
 - Subcutaneous
 
- SPECIES OBSERVED :
 - Rodent - rat
 
- DOSE/DURATION :
 - >2500 mg/kg
 
- TOXIC EFFECTS :
 - Details of toxic effects not reported other than lethal dose value
 
- REFERENCE :
 - APEPA2 Naunyn-Schmiedebergs Archiv fuer Pharmakologie und Experimentelle Pathologie. (Berlin, Ger.) V.254-263, 1966-69. For publisher information, see NSAPCC. Volume(issue)/page/year: 257,296,1967
 
- TYPE OF TEST :
 - LD50 - Lethal dose, 50 percent kill
 
- ROUTE OF EXPOSURE :
 - Unreported
 
- SPECIES OBSERVED :
 - Rodent - rat
 
- DOSE/DURATION :
 - 2400 mg/kg
 
- TOXIC EFFECTS :
 - Sense Organs and Special Senses (Eye) - corneal damage Behavioral - somnolence (general depressed activity) Musculoskeletal - other changes
 
- REFERENCE :
 - GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 57(2),30,1992
 
- TYPE OF TEST :
 - LD50 - Lethal dose, 50 percent kill
 
- ROUTE OF EXPOSURE :
 - Oral
 
- SPECIES OBSERVED :
 - Rodent - mouse
 
- DOSE/DURATION :
 - 2600 mg/kg
 
- TOXIC EFFECTS :
 - Details of toxic effects not reported other than lethal dose value
 
- REFERENCE :
 - TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 34,173,1985
 
- TYPE OF TEST :
 - LD50 - Lethal dose, 50 percent kill
 
- ROUTE OF EXPOSURE :
 - Intraperitoneal
 
- SPECIES OBSERVED :
 - Rodent - mouse
 
- DOSE/DURATION :
 - 802 mg/kg
 
- TOXIC EFFECTS :
 - Details of toxic effects not reported other than lethal dose value
 
- REFERENCE :
 - NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986
 
- TYPE OF TEST :
 - LD50 - Lethal dose, 50 percent kill
 
- ROUTE OF EXPOSURE :
 - Subcutaneous
 
- SPECIES OBSERVED :
 - Rodent - mouse
 
- DOSE/DURATION :
 - 3100 mg/kg
 
- TOXIC EFFECTS :
 - Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - weight loss or decreased weight gain Nutritional and Gross Metabolic - body temperature decrease
 
- REFERENCE :
 - DABBBA Dissertation Abstracts International, B: The Sciences and Engineering. (University Microfilms International, 300 N. Zeeb Rd., Ann Arbor, MI 48106) V.30- 1969- Volume(issue)/page/year: 40,549,1979
 
- TYPE OF TEST :
 - LD50 - Lethal dose, 50 percent kill
 
- ROUTE OF EXPOSURE :
 - Intravenous
 
- SPECIES OBSERVED :
 - Rodent - mouse
 
- DOSE/DURATION :
 - 1580 mg/kg
 
- TOXIC EFFECTS :
 - Details of toxic effects not reported other than lethal dose value
 
- REFERENCE :
 - TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 34,173,1985
 
- TYPE OF TEST :
 - LD50 - Lethal dose, 50 percent kill
 
- ROUTE OF EXPOSURE :
 - Intramuscular
 
- SPECIES OBSERVED :
 - Rodent - mouse
 
- DOSE/DURATION :
 - 2700 mg/kg
 
- TOXIC EFFECTS :
 - Details of toxic effects not reported other than lethal dose value
 
- REFERENCE :
 - TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 34,173,1985
 
- TYPE OF TEST :
 - LD50 - Lethal dose, 50 percent kill
 
- ROUTE OF EXPOSURE :
 - Unreported
 
- SPECIES OBSERVED :
 - Rodent - mouse
 
- DOSE/DURATION :
 - 1175 mg/kg
 
- TOXIC EFFECTS :
 - Sense Organs and Special Senses (Eye) - corneal damage Behavioral - somnolence (general depressed activity) Musculoskeletal - other changes
 
- REFERENCE :
 - GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 57(2),30,1992
 
- TYPE OF TEST :
 - LD - Lethal dose
 
- ROUTE OF EXPOSURE :
 - Intravenous
 
- SPECIES OBSERVED :
 - Mammal - dog
 
- DOSE/DURATION :
 - >568 mg/kg
 
- TOXIC EFFECTS :
 - Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain
 
- REFERENCE :
 - NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB82-232158
 
- TYPE OF TEST :
 - LD50 - Lethal dose, 50 percent kill
 
- ROUTE OF EXPOSURE :
 - Unreported
 
- SPECIES OBSERVED :
 - Rodent - guinea pig
 
- DOSE/DURATION :
 - 465 mg/kg
 
- TOXIC EFFECTS :
 - Sense Organs and Special Senses (Eye) - corneal damage Behavioral - somnolence (general depressed activity) Musculoskeletal - other changes
 
- REFERENCE :
 - GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 57(2),30,1992 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
- TYPE OF TEST :
 - TDLo - Lowest published toxic dose
 
- ROUTE OF EXPOSURE :
 - Oral
 
- SPECIES OBSERVED :
 - Rodent - rat
 
- DOSE/DURATION :
 - 5460 ug/kg/26W-I
 
- TOXIC EFFECTS :
 - Lungs, Thorax, or Respiration - changes in lung weight Blood - changes in leukocyte (WBC) count Nutritional and Gross Metabolic - changes in chlorine
 
- REFERENCE :
 - GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 57(2),30,1992
 
- TYPE OF TEST :
 - TCLo - Lowest published toxic concentration
 
- ROUTE OF EXPOSURE :
 - Inhalation
 
- SPECIES OBSERVED :
 - Rodent - rat
 
- DOSE/DURATION :
 - 400 ppm/6H/2W-I
 
- TOXIC EFFECTS :
 - Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
 
- REFERENCE :
 - FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 14,810,1990
 
- TYPE OF TEST :
 - TDLo - Lowest published toxic dose
 
- ROUTE OF EXPOSURE :
 - Intravenous
 
- SPECIES OBSERVED :
 - Rodent - mouse
 
- DOSE/DURATION :
 - 5603 mg/kg/5D-I
 
- TOXIC EFFECTS :
 - Liver - hepatitis (hepatocellular necrosis), zonal Endocrine - other changes Related to Chronic Data - death
 
- REFERENCE :
 - NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB82-232158
 
- TYPE OF TEST :
 - TDLo - Lowest published toxic dose
 
- ROUTE OF EXPOSURE :
 - Intraperitoneal
 
- SPECIES OBSERVED :
 - Rodent - mouse
 
- DOSE/DURATION :
 - 4 gm/kg/10D-I
 
- TOXIC EFFECTS :
 - Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
 
- REFERENCE :
 - TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 34,173,1985
 
- TYPE OF TEST :
 - TDLo - Lowest published toxic dose
 
- ROUTE OF EXPOSURE :
 - Intravenous
 
- SPECIES OBSERVED :
 - Mammal - dog
 
- DOSE/DURATION :
 - 662 mg/kg/5D-I
 
- TOXIC EFFECTS :
 - Liver - hepatitis (hepatocellular necrosis), zonal Endocrine - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
 
- REFERENCE :
 - NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB82-232158 ** REPRODUCTIVE DATA **
 
- TYPE OF TEST :
 - TDLo - Lowest published toxic dose
 
- ROUTE OF EXPOSURE :
 - Oral
 
- DOSE :
 - 1 gm/kg
 
- SEX/DURATION :
 - female 7 day(s) after conception
 
- TOXIC EFFECTS :
 - Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - homeostasis Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
 
- REFERENCE :
 - 85DJA5 "Malformations Congenitales des Mammiferes," Tuchmann-Duplessis, H., Paris, Masson et Cie, 1971 Volume(issue)/page/year: -,95,1971
 
- TYPE OF TEST :
 - TDLo - Lowest published toxic dose
 
- ROUTE OF EXPOSURE :
 - Oral
 
- DOSE :
 - 750 mg/kg
 
- SEX/DURATION :
 - female 6-15 day(s) after conception
 
- TOXIC EFFECTS :
 - Reproductive - Maternal Effects - other effects Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
 
- REFERENCE :
 - FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 27,239,1995
 
- TYPE OF TEST :
 - TDLo - Lowest published toxic dose
 
- ROUTE OF EXPOSURE :
 - Oral
 
- DOSE :
 - 750 mg/kg
 
- SEX/DURATION :
 - female 6-15 day(s) after conception
 
- TOXIC EFFECTS :
 - Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system
 
- REFERENCE :
 - FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 27,239,1995
 
- TYPE OF TEST :
 - TDLo - Lowest published toxic dose
 
- ROUTE OF EXPOSURE :
 - Administration onto the skin
 
- DOSE :
 - 1200 mg/kg
 
- SEX/DURATION :
 - female 12-13 day(s) after conception
 
- TOXIC EFFECTS :
 - Reproductive - Specific Developmental Abnormalities - body wall
 
- REFERENCE :
 - TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 41,35,1977
 
- TYPE OF TEST :
 - TDLo - Lowest published toxic dose
 
- ROUTE OF EXPOSURE :
 - Administration onto the skin
 
- DOSE :
 - 400 mg/kg
 
- SEX/DURATION :
 - female 12-13 day(s) after conception
 
- TOXIC EFFECTS :
 - Reproductive - Specific Developmental Abnormalities - Central Nervous System
 
- REFERENCE :
 - TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 41,35,1977
 
- TYPE OF TEST :
 - TDLo - Lowest published toxic dose
 
- ROUTE OF EXPOSURE :
 - Administration onto the skin
 
- DOSE :
 - 600 mg/kg
 
- SEX/DURATION :
 - female 9 day(s) after conception
 
- TOXIC EFFECTS :
 - Reproductive - Effects on Embryo or Fetus - fetal death
 
- REFERENCE :
 - TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 41,35,1977
 
- TYPE OF TEST :
 - TDLo - Lowest published toxic dose
 
- ROUTE OF EXPOSURE :
 - Intraperitoneal
 
- DOSE :
 - 700 mg/kg
 
- SEX/DURATION :
 - female 7-13 day(s) after conception
 
- TOXIC EFFECTS :
 - Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
 
- REFERENCE :
 - 85DJA5 "Malformations Congenitales des Mammiferes," Tuchmann-Duplessis, H., Paris, Masson et Cie, 1971 Volume(issue)/page/year: -,95,1971
 
- TYPE OF TEST :
 - TDLo - Lowest published toxic dose
 
- ROUTE OF EXPOSURE :
 - Subcutaneous
 
- DOSE :
 - 500 mg/kg
 
- SEX/DURATION :
 - female 10 day(s) after conception
 
- TOXIC EFFECTS :
 - Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
 
- REFERENCE :
 - APEPA2 Naunyn-Schmiedebergs Archiv fuer Pharmakologie und Experimentelle Pathologie. (Berlin, Ger.) V.254-263, 1966-69. For publisher information, see NSAPCC. Volume(issue)/page/year: 257,296,1967
 
- TYPE OF TEST :
 - TDLo - Lowest published toxic dose
 
- ROUTE OF EXPOSURE :
 - Oral
 
- DOSE :
 - 200 mg/kg
 
- SEX/DURATION :
 - female 11 day(s) after conception
 
- TOXIC EFFECTS :
 - Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system
 
- REFERENCE :
 - ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,610,1967
 
- TYPE OF TEST :
 - TDLo - Lowest published toxic dose
 
- ROUTE OF EXPOSURE :
 - Oral
 
- DOSE :
 - 400 mg/kg
 
- SEX/DURATION :
 - female 11 day(s) after conception
 
- TOXIC EFFECTS :
 - Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
 
- REFERENCE :
 - ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,610,1967
 
- TYPE OF TEST :
 - TDLo - Lowest published toxic dose
 
- ROUTE OF EXPOSURE :
 - Administration onto the skin
 
- DOSE :
 - 400 mg/kg
 
- SEX/DURATION :
 - female 11 day(s) after conception
 
- TOXIC EFFECTS :
 - Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system
 
- REFERENCE :
 - ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,610,1967
 
- TYPE OF TEST :
 - TDLo - Lowest published toxic dose
 
- ROUTE OF EXPOSURE :
 - Administration onto the skin
 
- DOSE :
 - 800 mg/kg
 
- SEX/DURATION :
 - female 11 day(s) after conception
 
- TOXIC EFFECTS :
 - Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
 
- REFERENCE :
 - ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,610,1967
 
- TYPE OF TEST :
 - TDLo - Lowest published toxic dose
 
- ROUTE OF EXPOSURE :
 - Subcutaneous
 
- DOSE :
 - 70 mg/kg
 
- SEX/DURATION :
 - female 11 day(s) after conception
 
- TOXIC EFFECTS :
 - Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
 
- REFERENCE :
 - DABBBA Dissertation Abstracts International, B: The Sciences and Engineering. (University Microfilms International, 300 N. Zeeb Rd., Ann Arbor, MI 48106) V.30- 1969- Volume(issue)/page/year: 40,549,1979
 
- TYPE OF TEST :
 - TDLo - Lowest published toxic dose
 
- ROUTE OF EXPOSURE :
 - Oral
 
- DOSE :
 - 650 mg/kg
 
- SEX/DURATION :
 - female 6-18 day(s) after conception
 
- TOXIC EFFECTS :
 - Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
 
- REFERENCE :
 - ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 30,1557,1980
 
- TYPE OF TEST :
 - TDLo - Lowest published toxic dose
 
- ROUTE OF EXPOSURE :
 - Oral
 
- DOSE :
 - 650 mg/kg
 
- SEX/DURATION :
 - female 6-18 day(s) after conception
 
- TOXIC EFFECTS :
 - Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
 
- REFERENCE :
 - ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 30,1557,1980
 
- TYPE OF TEST :
 - TDLo - Lowest published toxic dose
 
- ROUTE OF EXPOSURE :
 - Oral
 
- DOSE :
 - 650 mg/kg
 
- SEX/DURATION :
 - female 6-18 day(s) after conception
 
- TOXIC EFFECTS :
 - Reproductive - Maternal Effects - other effects Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - Central Nervous System
 
- REFERENCE :
 - FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 27,239,1995
 
- TYPE OF TEST :
 - TDLo - Lowest published toxic dose
 
- ROUTE OF EXPOSURE :
 - Oral
 
- DOSE :
 - 650 mg/kg
 
- SEX/DURATION :
 - female 6-18 day(s) after conception
 
- TOXIC EFFECTS :
 - Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - gastrointestinal system
 
- REFERENCE :
 - FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 27,239,1995
 
- TYPE OF TEST :
 - TDLo - Lowest published toxic dose
 
- ROUTE OF EXPOSURE :
 - Administration onto the skin
 
- DOSE :
 - 1800 mg/kg
 
- SEX/DURATION :
 - female 8-16 day(s) after conception
 
- TOXIC EFFECTS :
 - Reproductive - Effects on Embryo or Fetus - fetal death
 
- REFERENCE :
 - TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 41,35,1977
 
Safety Information
[ Symbol ]:
                
                
                GHS07, GHS08
            
[ Signal Word ]: 
Danger
            
[ Hazard Statements ]:
 H312-H360
            
[ Precautionary Statements ]:
 P201-P280-P308 + P313
            
[ Personal Protective Equipment ]:
 Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
            
[ Hazard Codes ]:
 T:Toxic;
            
[ Risk Phrases ]:
 R21;R61
            
[ Safety Phrases ]:
 S53-S45
            
[ RIDADR ]: 
NONH for all modes of transport
            
[ WGK Germany ]: 
1
            
[ RTECS ]: 
LQ3000000
            
[ Packaging Group ]:
 II
            
[ HS Code ]:
 2924199090
            
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2924199090
[ Summary ]: 
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
            
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