Pyrrolidine

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Names

[ CAS No. ]:
123-75-1

[ Name ]:
Pyrrolidine

[Synonym ]:
Tetrahydro pyrrole
Pyrrolidine [UN1922] [Flammable liquid]
Pyrrole, tetrahydro-
Tetramethyleneimine
Pyrrolidinepyrrolidine
Azolan
EINECS 204-648-7
1-Azacyclopentane
T5MTJ
Tetrahydropyrrole,Tetramethyleneimine
MFCD00005249
Pyrrolidine
Tetrahydropyrrole

Chemical & Physical Properties

[ Density]:
0.8±0.1 g/cm3

[ Boiling Point ]:
89.5±8.0 °C at 760 mmHg

[ Melting Point ]:
-63 °C

[ Molecular Formula ]:
C4H9N

[ Molecular Weight ]:
71.121

[ Flash Point ]:
2.8±0.0 °C

[ Exact Mass ]:
71.073502

[ PSA ]:
12.03000

[ LogP ]:
0.37

[ Vapour density ]:
2.45 (vs air)

[ Vapour Pressure ]:
58.6±0.2 mmHg at 25°C

[ Index of Refraction ]:
1.428

[ Stability ]:
Stable; flammable. Incompatible with strong acids, strong oxidizing agents.

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UX9650000
CHEMICAL NAME :
Pyrrolidine
CAS REGISTRY NUMBER :
123-75-1
BEILSTEIN REFERENCE NO. :
0102395
LAST UPDATED :
199701
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C4-H9-N
MOLECULAR WEIGHT :
71.14
WISWESSER LINE NOTATION :
T5MTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Vascular - other changes
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 18(2),29,1974
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
450 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 103,414,1964
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1300 mg/m3/2H
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Vascular - other changes
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 18(2),29,1974
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
420 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 88,82,1946
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#06769
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,104,1982
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,104,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 39(4),86,1974 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.1 mg/m3;Skin JAN 1993

Safety Information

[ Symbol ]:

GHS02, GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H302 + H332-H314

[ Precautionary Statements ]:
P210-P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
F:Flammable;C:Corrosive;

[ Risk Phrases ]:
R11;R20/21/22;R35

[ Safety Phrases ]:
S16-S26-S36/37/39-S45-S33

[ RIDADR ]:
UN 1922 3/PG 2

[ WGK Germany ]:
2

[ RTECS ]:
UX9650000

[ Packaging Group ]:
II

[ Hazard Class ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Precursor & DownStream

Precursor

  • Pyrrole
  • 4-Amino-1-butanol
  • 2-Pyrrolidinone
  • 1,4-Butanediol
  • 1-Pyrrolidinecarboxylicacid, methyl ester
  • putrescine
  • 1-Pyrrolidinecarboxylicacid,2-propynylester(9CI)
  • 1-Pyrrolidinecarboxylicacid, ethyl ester
  • Succinonitrile

DownStream

  • SNT-207707
  • 1,2,4-Triazine,3-(1-pyrrolidinyl)-
  • 1-(4-nitronaphthalen-1-yl)pyrrolidine
  • N-Benzylcyclohexylamine
  • Cyclohexanamine,N-(phenylmethylene)-
  • methylamine
  • 1-benzylpyrrolidine
  • N-BENZOYL PYRROLIDINE
  • 5,7-diphenyl-2,3-dihydro-1H-pyrrolizine

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Related Compounds

  • 3-pyrrolidine
  • pyrrolidine-N-d
  • pyrrolidinedione
  • pyrrolidineamide
  • allylpyrrolidine
  • Allylpyrrolidine
  • 4-(Butylamino)-2-(oxan-4-yl)butan-1-ol
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-[3-(dimethylamino)-N-[2-(dimethylamino)ethyl]-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanamido]acetic acid
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • 1-[(5-Ethyl-1,3,4-thiadiazol-2-yl)methyl]cyclopropane-1-carbaldehyde
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde