Pyrrolidine

Suppliers

Names

[ CAS No. ]:
123-75-1

[ Name ]:
Pyrrolidine

[Synonym ]:
Tetrahydro pyrrole
Pyrrolidine [UN1922] [Flammable liquid]
Pyrrole, tetrahydro-
Tetramethyleneimine
Pyrrolidinepyrrolidine
Azolan
EINECS 204-648-7
1-Azacyclopentane
T5MTJ
Tetrahydropyrrole,Tetramethyleneimine
MFCD00005249
Pyrrolidine
Tetrahydropyrrole

Chemical & Physical Properties

[ Density]:
0.8±0.1 g/cm3

[ Boiling Point ]:
89.5±8.0 °C at 760 mmHg

[ Melting Point ]:
-63 °C

[ Molecular Formula ]:
C₄H₉N

[ Molecular Weight ]:
71.121

[ Flash Point ]:
2.8±0.0 °C

[ Exact Mass ]:
71.073502

[ PSA ]:
12.03000

[ LogP ]:
0.37

[ Vapour density ]:
2.45 (vs air)

[ Vapour Pressure ]:
58.6±0.2 mmHg at 25°C

[ Index of Refraction ]:
1.428

[ Stability ]:
Stable; flammable. Incompatible with strong acids, strong oxidizing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UX9650000

CHEMICAL NAME :: Pyrrolidine

CAS REGISTRY NUMBER :: 123-75-1

BEILSTEIN REFERENCE NO. :: 0102395

LAST UPDATED :: 199701

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C4-H9-N

MOLECULAR WEIGHT :: 71.14

WISWESSER LINE NOTATION :: T5MTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Vascular - other changes

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 18(2),29,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 103,414,1964

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1300 mg/m3/2H

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Vascular - other changes

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 18(2),29,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 420 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 88,82,1946

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#06769

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,104,1982

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,104,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 39(4),86,1974 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.1 mg/m3;Skin JAN 1993

Safety Information

[ Symbol ]:

GHS02, GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H302 + H332-H314

[ Precautionary Statements ]:
P210-P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
F:Flammable;C:Corrosive;

[ Risk Phrases ]:
R11;R20/21/22;R35

[ Safety Phrases ]:
S16-S26-S36/37/39-S45-S33

[ RIDADR ]:
UN 1922 3/PG 2

[ WGK Germany ]:
2

[ RTECS ]:
UX9650000

[ Packaging Group ]:
II

[ Hazard Class ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Pyrrole
4-Amino-1-butanol
2-Pyrrolidinone
1,4-Butanediol
1-Pyrrolidinecarboxylicacid, methyl ester
putrescine
1-Pyrrolidinecarboxylicacid,2-propynylester(9CI)
1-Pyrrolidinecarboxylicacid, ethyl ester
Succinonitrile

DownStream

SNT-207707
1,2,4-Triazine,3-(1-pyrrolidinyl)-
1-(4-nitronaphthalen-1-yl)pyrrolidine
N-Benzylcyclohexylamine
Cyclohexanamine,N-(phenylmethylene)-
methylamine
1-benzylpyrrolidine
N-BENZOYL PYRROLIDINE
5,7-diphenyl-2,3-dihydro-1H-pyrrolizine

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Prediction of the chromatographic retention of acid-base compounds in pH buffered methanol-water mobile phases in gradient mode by a simplified model.

J. Chromatogr. A. 1385 , 42-8, (2015)

Retention of ionizable analytes under gradient elution depends on the pH of the mobile phase, the pKa of the analyte and their evolution along the programmed gradient. In previous work, a model depend...

Electrospray ionization mass spectrometry of non-covalent complexes formed between N-alkylimidazolium-containing zwitterionic sulfonates and protonated bases.

Eur. J. Mass Spectrom. (Chichester, Eng.) 20(6) , 467-75, (2015)

This paper describes non-covalent complexes between zwitterionic 3-(1-alkyl-3N-imidazolio)- propane-1-sulfonates and different amines. Electrospray ionization (ESI) mass spectrometry and collision- in...

Attractors in Sequence Space: Peptide Morphing by Directed Simulated Evolution.

Mol. Inform. 34 , 709-714, (2016)