Topotecan hydrochloride hydrate

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Names

[ CAS No. ]:
123948-87-8

[ Name ]:
Topotecan hydrochloride hydrate

[Synonym ]:
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-
MFCD00866235
10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Topotecan hydrochloride hydrate
9-[(dimethylamino)methyl]-10-hydroxy-(20S)-camptothecin hydrochloride hydrate
Topotecan
EINECS 231-595-7

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
782.9±60.0 °C at 760 mmHg

[ Melting Point ]:
−114 °C(lit.)

[ Molecular Formula ]:
C23H23N3O5

[ Molecular Weight ]:
421.446

[ Flash Point ]:
427.3±32.9 °C

[ Exact Mass ]:
421.163757

[ PSA ]:
104.89000

[ LogP ]:
1.08

[ Vapour density ]:
1.3 (vs air)

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.734

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
H2O: soluble

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
T,C,F,Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S45-S36/37/39

[ RIDADR ]:
UN 3286 3/PG 2

[ WGK Germany ]:
2

[ RTECS ]:
MW4025000

[ Packaging Group ]:
II

[ Hazard Class ]:
8

[ HS Code ]:
2942000000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (S)-10-Hydroxycamptothecin
  • N,N-Dimethylmethyleneiminium chloride
  • Dichloromethane
  • Dimethylamine
  • Formaldehyde
  • Campathecin

DownStream

  • Topotecan hydrochloride

Customs

[ HS Code ]: 2942000000

Related Compounds

  • Topotecan hydrochloride hydrate
  • Topotecan hydrochloride
  • Fasudil Hydrochloride Hydrate
  • mitoguazone hydrochloride hydrate
  • (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-hydroxyiminoacetyl]amino]-8-oxo-3-(2H-triazol-4-ylsulfanylmethylsulfanyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,hydrate,hydrochloride
  • Adimolol hydrochloride hydrate
  • Benzyl 3-bromo-2-formyl-6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate
  • 4-(4,4-Difluorocyclohexyl)butanal
  • 5-Amino-3-bromo-1-(2-cyclobutylethyl)-1,2-dihydropyridin-2-one
  • 4-(3-Chloro-4-ethoxyphenyl)morpholin-3-one
  • 5-(3-Oxomorpholin-4-yl)benzene-1,3-dicarboxylic acid
  • 5-(1,1-difluoropropyl)-4-propyl-4H-1,2,4-triazole-3-thiol
  • 3-[(3-Methoxycyclohexyl)oxy]-2,3-dihydro-1lambda6-thiophene-1,1-dione
  • 9-Methyl-2-propyl-1-oxa-5,9-diazaspiro[5.6]dodecane
  • 1-[2-(2-aminoethyl)-4,5-dihydro-1H-imidazol-1-yl]propan-1-one
  • Methyl 2-[({1-methyl-2-oxabicyclo[2.2.2]octan-4-yl}methyl)amino]acetate
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