Tetra(hydroxymethyl)phosphonium chloride

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Names

[ CAS No. ]:
124-64-1

[ Name ]:
Tetra(hydroxymethyl)phosphonium chloride

[Synonym ]:
Tetra(hydroxymethyl)phosphonium chloride
EINECS 204-707-7
Phosphonium, tetrakis(hydroxymethyl)-, chloride (1:1)
tetrakis(hydroxymethyl)phosphanium,chloride
MFCD00031687
Tetrakis(hydroxymethyl)phosphonium chloride

Chemical & Physical Properties

[ Density]:
1.341 g/mL at 25 °C

[ Boiling Point ]:
115°C/760mmHg

[ Melting Point ]:
154°C

[ Molecular Formula ]:
C4H12ClO4P

[ Molecular Weight ]:
190.562

[ Flash Point ]:
> 96ºC

[ Exact Mass ]:
190.016174

[ PSA ]:
94.51000

[ Index of Refraction ]:
n20/D 1.512

[ Water Solubility ]:
>=10 g/100 mL at 20 ºC

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TA2450000
CHEMICAL NAME :
Phosphonium, tetrakis(hydroxymethyl)-, chloride
CAS REGISTRY NUMBER :
124-64-1
LAST UPDATED :
199710
DATA ITEMS CITED :
20
MOLECULAR FORMULA :
C4-H12-O4-P.Cl
MOLECULAR WEIGHT :
190.58
WISWESSER LINE NOTATION :
Q1P1Q1Q1Q &G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
161 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
125 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
3800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7200 mg/kg/90D-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - sensory syndrome diagnostic of central lesion Behavioral - muscle weakness

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
5000 ppm
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 6,259,1980 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 48,95,1990 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 48,95,1990 TOXICOLOGY REVIEW CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. Volume(issue)/page/year: 17,101,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T0112 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 100 (estimated)

Safety Information

[ Hazard Codes ]:
T:Toxic;N:Dangerousfortheenvironment;

[ Risk Phrases ]:
R21;R25;R38;R41;R42/43;R51/53

[ Safety Phrases ]:
S22-S26-S36/37/39-S45-S60-S61

[ RIDADR ]:
UN 2810 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
TA2450000

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2931900090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Formaldehyde
  • Phosphine
  • phosphanetriyltrimethanol

DownStream

  • Phosphinic acid,P,P-bis(hydroxymethyl)-
  • Phosphonium,tetrakis(chloromethyl)-, chloride (1:1)
  • phosphanetriyltrimethanol
  • Phosphoryltrimethanol
  • di(4-tolyl)methylphosphine oxide
  • tris(4-methylphenyl)phosphine oxide
  • 1-phenyl-3-[(phenylcarbamoylamino)methyl]urea
  • bis(hydroxymethyl)phosphorylmethylthiourea
  • Phosphine oxide, tris(4-chlorophenyl)- (9CI)
  • 1-chloro-4-[(4-chlorophenyl)-phosphorosomethyl]benzene

Customs

[ HS Code ]: 2931900090

[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

Related Compounds

  • Tris(hydroxymethyl)phosphonium chloride
  • Tetrakis(hydroxymethyl)phosphonium chloride urea polymer
  • tri-(hydroxymethyl)phenylphosphonium chloride
  • bis(hydroxymethyl)-diphenylphosphanium,chloride
  • tetrakis(hydroxymethyl)phosphonium phosphate(2:1)
  • tetrakis(hydroxymethyl)phosphonium acetate
  • 2-Amino-2-(5-chloro-2-fluoropyridin-3-yl)ethan-1-ol
  • 2-Acetyl-2-ethyl-5-fluoroindan-1-one
  • 2-([1,2,4]triazolo[4,3-b]pyridazin-6-ylsulfanyl)-N-(3,4,5-trimethoxyphenyl)acetamide
  • 1,3-Dichloro-4-isopropoxy-2-methylbenzene
  • 4-Ethyl-7-nitro-1(2h)-isoquinolinone
  • 5-Bromo-2-ethyl-3,4-dihydropyrimidin-4-one
  • 2,3-Dihydro-4-methyl-2-oxo-N-(1H-1,2,4-triazol-5-ylmethyl)-5-thiazolesulfonamide
  • 5-{[3-(4-bromophenyl)-1,2,4-oxadiazol-5-yl]methyl}-2-(4-fluorophenyl)pyrazolo[1,5-a]pyrazin-4(5H)-one
  • 3-[11-(3,4-dimethylphenyl)-3,4,6,9,10-pentaazatricyclo[7.3.0.0^{2,6}]dodeca-1(12),2,4,7,10-pentaen-5-yl]-N-{[4-(methylsulfanyl)phenyl]methyl}propanamide
  • 3-[11-(4-methoxyphenyl)-3,4,6,9,10-pentaazatricyclo[7.3.0.0^{2,6}]dodeca-1(12),2,4,7,10-pentaen-5-yl]-N-[(4-methylphenyl)methyl]propanamide
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