meprednisone

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Names

[ CAS No. ]:
1247-42-3

[ Name ]:
meprednisone

[Synonym ]:
(16b)-17,21-Dihydroxy-16-methylpregna-1,4-diene-3,11,20-trione
16β-Methylprednisone
methylprednisone
deltisonab
(16β)-17,21-Dihydroxy-16-methylpregna-1,4-diene-3,11,20-trione
Deltisona B
16b-Methylprednisone
Betapred
Betalone
Betapar
Pregna-1,4-diene-3,11,20-trione, 17,21-dihydroxy-16-methyl-, (16β)-
17,21-Dihydroxy-16β-methylpregna-1,4-diene-3,11,20-trione
meprednisone
17,21-Dihydroxy-16b-methylpregna-1,4-diene-3,11,20-trione
Bitanisone
Betanisona

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
574.4±50.0 °C at 760 mmHg

[ Melting Point ]:
204-206ºC

[ Molecular Formula ]:
C22H28O5

[ Molecular Weight ]:
372.455

[ Flash Point ]:
315.2±26.6 °C

[ Exact Mass ]:
372.193665

[ PSA ]:
91.67000

[ LogP ]:
2.06

[ Vapour Pressure ]:
0.0±3.6 mmHg at 25°C

[ Index of Refraction ]:
1.595

[ Storage condition ]:
2~8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU4154090
CHEMICAL NAME :
Pregna-1,4-diene-3,11,20-trione, 17,21-dihydroxy-16-beta-methyl-
CAS REGISTRY NUMBER :
1247-42-3
LAST UPDATED :
198910
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C22-H28-O5
MOLECULAR WEIGHT :
372.50
WISWESSER LINE NOTATION :
L E5 B666 CV OV AHTTT&J A1 E1 FV1Q FQ G1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
14 mg/kg
SEX/DURATION :
female 16-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems (including spleen and marrow) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 30,1098,1974
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
6250 ug/kg
SEX/DURATION :
female 15-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
PEREBL Pediatric Research. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1967- Volume(issue)/page/year: 11,1042,1977

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2937210000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Meprednisone Acetate

DownStream

Customs

[ HS Code ]: 2937210000

Related Compounds

  • Meprednisone Acetate
  • 16-Meprednisone acetate
  • Meprednisone hemisuccinate
  • N-((1H-benzo[d]imidazol-2-yl)methyl)-5-cyclopropylisoxazole-3-carboxamide
  • (5-cyclopropylisoxazol-3-yl)(2,3-dihydro-1H-benzo[d]imidazo[1,2-a]imidazol-1-yl)methanone
  • ethyl 2-(5-cyclopropylisoxazole-3-carboxamido)-5,6-dihydro-4H-cyclopenta[d]thiazole-4-carboxylate
  • 5-cyclopropyl-N-(2-(pyridin-4-yl)ethyl)isoxazole-3-carboxamide
  • 1-methyl-N-(4-(trifluoromethyl)phenyl)-1H-1,2,3-triazole-4-carboxamide
  • 1-methyl-N-(6-(methylsulfonyl)benzo[d]thiazol-2-yl)-1H-1,2,3-triazole-4-carboxamide
  • ethyl 2-(1-methyl-1H-1,2,3-triazole-4-carboxamido)-5,6-dihydro-4H-cyclopenta[d]thiazole-4-carboxylate
  • N-(2-(3-(furan-2-yl)-6-oxopyridazin-1(6H)-yl)ethyl)-1-methyl-1H-1,2,3-triazole-4-carboxamide
  • 2-(cyclopentylthio)-N-(2-methylquinolin-5-yl)acetamide
  • 2-((1-methyl-1H-tetrazol-5-yl)thio)-N-(2-methylquinolin-5-yl)acetamide
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