meprednisone

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Names

[ CAS No. ]:
1247-42-3

[ Name ]:
meprednisone

[Synonym ]:
(16b)-17,21-Dihydroxy-16-methylpregna-1,4-diene-3,11,20-trione
16β-Methylprednisone
methylprednisone
deltisonab
(16β)-17,21-Dihydroxy-16-methylpregna-1,4-diene-3,11,20-trione
Deltisona B
16b-Methylprednisone
Betapred
Betalone
Betapar
Pregna-1,4-diene-3,11,20-trione, 17,21-dihydroxy-16-methyl-, (16β)-
17,21-Dihydroxy-16β-methylpregna-1,4-diene-3,11,20-trione
meprednisone
17,21-Dihydroxy-16b-methylpregna-1,4-diene-3,11,20-trione
Bitanisone
Betanisona

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
574.4±50.0 °C at 760 mmHg

[ Melting Point ]:
204-206ºC

[ Molecular Formula ]:
C22H28O5

[ Molecular Weight ]:
372.455

[ Flash Point ]:
315.2±26.6 °C

[ Exact Mass ]:
372.193665

[ PSA ]:
91.67000

[ LogP ]:
2.06

[ Vapour Pressure ]:
0.0±3.6 mmHg at 25°C

[ Index of Refraction ]:
1.595

[ Storage condition ]:
2~8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU4154090
CHEMICAL NAME :
Pregna-1,4-diene-3,11,20-trione, 17,21-dihydroxy-16-beta-methyl-
CAS REGISTRY NUMBER :
1247-42-3
LAST UPDATED :
198910
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C22-H28-O5
MOLECULAR WEIGHT :
372.50
WISWESSER LINE NOTATION :
L E5 B666 CV OV AHTTT&J A1 E1 FV1Q FQ G1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
14 mg/kg
SEX/DURATION :
female 16-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems (including spleen and marrow) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 30,1098,1974
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
6250 ug/kg
SEX/DURATION :
female 15-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
PEREBL Pediatric Research. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1967- Volume(issue)/page/year: 11,1042,1977

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2937210000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Meprednisone Acetate

DownStream

Customs

[ HS Code ]: 2937210000

Related Compounds

  • Meprednisone Acetate
  • 16-Meprednisone acetate
  • Meprednisone hemisuccinate
  • 4-{2-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]-4-methylpentanamido}-4-methylpentanoic acid
  • 4-{[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-methylcyclohexyl]formamido}-3-methylbutanoic acid
  • 4-[(2S)-N-ethyl-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanamido]butanoic acid
  • 1-[(2S,3S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylpentanoyl]-2-methylpiperidine-3-carboxylic acid
  • 1-[(5-Methylpyridin-3-yl)sulfanyl]pentan-2-one
  • 2,2'-(1-Methyl-1,4-butanediyl)bis-1H-isoindole-1,3(2H)-dione
  • 2-Bromo-6-(3-methylpiperidin-1-yl)pyridine-3-carbonitrile
  • tert-butyl N-[2-amino-2-(6-chloro-5-methylpyridin-3-yl)ethyl]carbamate
  • 4-fluoro-1-methyl-3-(5-methylfuran-2-yl)-1H-pyrazol-5-amine
  • 7-(4-Fluoro-3-methylphenyl)azepan-2-one
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