meprednisone
Modify Date: 2025-08-20 07:21:09
meprednisone structure
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Common Name | meprednisone | ||
|---|---|---|---|---|
| CAS Number | 1247-42-3 | Molecular Weight | 372.455 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 574.4±50.0 °C at 760 mmHg | |
| Molecular Formula | C22H28O5 | Melting Point | 204-206ºC | |
| MSDS | N/A | Flash Point | 315.2±26.6 °C | |
Use of meprednisoneMeprednisone is a glucocorticoid and a methylated derivative of prednisone.Target: Glucocorticoid ReceptorMeprednisone is a glucocorticoid and a methylated derivative of prednisone. The methylprednisone to MPL area under the curve ratio decreased from 0.19 +/- 0.04 in control to 0.14 +/- 0.03 in ketoconazole-treated rats (P less than .05) due to altered interconversion between these steroids. An improved pharmacokinetic/dynamic receptor/gene-mediated model characterized the steroid receptor binding and induction of tyrosine aminotransferase activity after i.v. MPL sodium succinate (10 mg/kg). In contrast to previous in vitro studies, ketoconazole at maximally tolerated doses failed to antagonize the steroid receptor-mediated activity of MPL [1]. |
| Name | Meprednisone |
|---|---|
| Synonym | More Synonyms |
| Description | Meprednisone is a glucocorticoid and a methylated derivative of prednisone.Target: Glucocorticoid ReceptorMeprednisone is a glucocorticoid and a methylated derivative of prednisone. The methylprednisone to MPL area under the curve ratio decreased from 0.19 +/- 0.04 in control to 0.14 +/- 0.03 in ketoconazole-treated rats (P less than .05) due to altered interconversion between these steroids. An improved pharmacokinetic/dynamic receptor/gene-mediated model characterized the steroid receptor binding and induction of tyrosine aminotransferase activity after i.v. MPL sodium succinate (10 mg/kg). In contrast to previous in vitro studies, ketoconazole at maximally tolerated doses failed to antagonize the steroid receptor-mediated activity of MPL [1]. |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 574.4±50.0 °C at 760 mmHg |
| Melting Point | 204-206ºC |
| Molecular Formula | C22H28O5 |
| Molecular Weight | 372.455 |
| Flash Point | 315.2±26.6 °C |
| Exact Mass | 372.193665 |
| PSA | 91.67000 |
| LogP | 2.06 |
| Vapour Pressure | 0.0±3.6 mmHg at 25°C |
| Index of Refraction | 1.595 |
| Storage condition | 2~8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| RIDADR | NONH for all modes of transport |
|---|---|
| HS Code | 2937210000 |
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meprednisone CAS#:1247-42-3 |
| Literature: Journal of the American Chemical Society, , vol. 80, p. 4428 Journal of the American Chemical Society, , vol. 80, p. 4435 Journal of the American Chemical Society, , vol. 82, p. 4012,4025 |
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meprednisone CAS#:1247-42-3 |
| Literature: Journal of the American Chemical Society, , vol. 80, p. 4428 Journal of the American Chemical Society, , vol. 80, p. 4435 Journal of the American Chemical Society, , vol. 82, p. 4012,4025 |
| Precursor 1 | |
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| DownStream 0 | |
| HS Code | 2937210000 |
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| (16b)-17,21-Dihydroxy-16-methylpregna-1,4-diene-3,11,20-trione |
| 16β-Methylprednisone |
| methylprednisone |
| deltisonab |
| (16β)-17,21-Dihydroxy-16-methylpregna-1,4-diene-3,11,20-trione |
| Deltisona B |
| 16b-Methylprednisone |
| Betapred |
| Betalone |
| Betapar |
| Pregna-1,4-diene-3,11,20-trione, 17,21-dihydroxy-16-methyl-, (16β)- |
| 17,21-Dihydroxy-16β-methylpregna-1,4-diene-3,11,20-trione |
| meprednisone |
| 17,21-Dihydroxy-16b-methylpregna-1,4-diene-3,11,20-trione |
| Bitanisone |
| Betanisona |