meprednisone

Modify Date: 2024-01-02 15:46:24

meprednisone Structure
meprednisone structure
 Common Name meprednisone
CAS Number 1247-42-3 Molecular Weight 372.455
Density 1.3±0.1 g/cm3 Boiling Point 574.4±50.0 °C at 760 mmHg
Molecular Formula C22H28O5 Melting Point 204-206ºC
MSDS N/A Flash Point 315.2±26.6 °C

 Use of meprednisone


Meprednisone is a glucocorticoid and a methylated derivative of prednisone.Target: Glucocorticoid ReceptorMeprednisone is a glucocorticoid and a methylated derivative of prednisone. The methylprednisone to MPL area under the curve ratio decreased from 0.19 +/- 0.04 in control to 0.14 +/- 0.03 in ketoconazole-treated rats (P less than .05) due to altered interconversion between these steroids. An improved pharmacokinetic/dynamic receptor/gene-mediated model characterized the steroid receptor binding and induction of tyrosine aminotransferase activity after i.v. MPL sodium succinate (10 mg/kg). In contrast to previous in vitro studies, ketoconazole at maximally tolerated doses failed to antagonize the steroid receptor-mediated activity of MPL [1].

 Names

Name Meprednisone
Synonym More Synonyms

 meprednisone Biological Activity

Description Meprednisone is a glucocorticoid and a methylated derivative of prednisone.Target: Glucocorticoid ReceptorMeprednisone is a glucocorticoid and a methylated derivative of prednisone. The methylprednisone to MPL area under the curve ratio decreased from 0.19 +/- 0.04 in control to 0.14 +/- 0.03 in ketoconazole-treated rats (P less than .05) due to altered interconversion between these steroids. An improved pharmacokinetic/dynamic receptor/gene-mediated model characterized the steroid receptor binding and induction of tyrosine aminotransferase activity after i.v. MPL sodium succinate (10 mg/kg). In contrast to previous in vitro studies, ketoconazole at maximally tolerated doses failed to antagonize the steroid receptor-mediated activity of MPL [1].
Related Catalog
References

[1]. Scheuer, E. and E. Warshaw, Allergy to corticosteroids: update and review of epidemiology, clinical characteristics, and structural cross-reactivity. Am J Contact Dermat, 2003. 14(4): p. 179-87.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 574.4±50.0 °C at 760 mmHg
Melting Point 204-206ºC
Molecular Formula C22H28O5
Molecular Weight 372.455
Flash Point 315.2±26.6 °C
Exact Mass 372.193665
PSA 91.67000
LogP 2.06
Vapour Pressure 0.0±3.6 mmHg at 25°C
Index of Refraction 1.595
Storage condition 2~8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU4154090
CHEMICAL NAME :
Pregna-1,4-diene-3,11,20-trione, 17,21-dihydroxy-16-beta-methyl-
CAS REGISTRY NUMBER :
1247-42-3
LAST UPDATED :
198910
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C22-H28-O5
MOLECULAR WEIGHT :
372.50
WISWESSER LINE NOTATION :
L E5 B666 CV OV AHTTT&J A1 E1 FV1Q FQ G1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
14 mg/kg
SEX/DURATION :
female 16-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems (including spleen and marrow) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 30,1098,1974
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
6250 ug/kg
SEX/DURATION :
female 15-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
PEREBL Pediatric Research. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1967- Volume(issue)/page/year: 11,1042,1977

 Safety Information

RIDADR NONH for all modes of transport
HS Code 2937210000

 Synthetic Route

Meprednisone Acetate structure

Meprednisone Acetate

CAS#:1106-03-2

~%

meprednisone Structure

meprednisone

CAS#:1247-42-3

Literature: Journal of the American Chemical Society, , vol. 80, p. 4428 Journal of the American Chemical Society, , vol. 80, p. 4435 Journal of the American Chemical Society, , vol. 82, p. 4012,4025
N/A structure

N/A

CAS#:1253-36-7

~%

meprednisone Structure

meprednisone

CAS#:1247-42-3

Literature: Journal of the American Chemical Society, , vol. 80, p. 4428 Journal of the American Chemical Society, , vol. 80, p. 4435 Journal of the American Chemical Society, , vol. 82, p. 4012,4025

 Precursor & DownStream

Precursor  1

DownStream  0

 Customs

HS Code 2937210000

 Synonyms

(16b)-17,21-Dihydroxy-16-methylpregna-1,4-diene-3,11,20-trione
16β-Methylprednisone
methylprednisone
deltisonab
(16β)-17,21-Dihydroxy-16-methylpregna-1,4-diene-3,11,20-trione
Deltisona B
16b-Methylprednisone
Betapred
Betalone
Betapar
Pregna-1,4-diene-3,11,20-trione, 17,21-dihydroxy-16-methyl-, (16β)-
17,21-Dihydroxy-16β-methylpregna-1,4-diene-3,11,20-trione
meprednisone
17,21-Dihydroxy-16b-methylpregna-1,4-diene-3,11,20-trione
Bitanisone
Betanisona
Top Suppliers:I want be here

Get all suppliers and price by the below link:

meprednisone suppliers

Price: $115/10mg

Reference only. check more meprednisone price

Related Compounds: More...
Meprednisone Acetate
1106-03-2
16-Meprednisone acetate
24510-55-2
Meprednisone hemisuccinate
27303-92-0
N-(3-acetylphenyl)-2-[2-(4-methoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide
941938-35-8
N-(2-chlorophenyl)-2-(2-(4-ethoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl)acetamide
941981-17-5
2-(2-(4-ethoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl)-N-(3-(methylthio)phenyl)acetamide
941938-52-9
2-(6-chloro-4-(2-fluorophenyl)-2-oxoquinazolin-1(2H)-yl)-N-(2-methoxyphenyl)acetamide
932530-95-5
2-(6-chloro-4-(2-fluorophenyl)-2-oxoquinazolin-1(2H)-yl)-N-(4-methoxyphenyl)acetamide
941939-52-2
ethyl 4-({[6-chloro-4-(2-fluorophenyl)-2-oxoquinazolin-1(2H)-yl]acetyl}amino)benzoate
932458-25-8
2-(6-chloro-4-(2-fluorophenyl)-2-oxoquinazolin-1(2H)-yl)-N-(3,4-dimethylphenyl)acetamide
941877-15-2
2-(6-chloro-4-(2-fluorophenyl)-2-oxoquinazolin-1(2H)-yl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acetamide
941939-58-8
N-[(2H-1,3-benzodioxol-5-yl)methyl]-2-[6-chloro-4-(2-fluorophenyl)-2-oxo-1,2-dihydroquinazolin-1-yl]acetamide
932321-52-3
N-(3-chloro-4-fluorophenyl)-6-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-3-carboxamide 1,1-dioxide
941939-67-9
Chemsrc provides meprednisone(CAS#:1247-42-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of meprednisone are included as well.>> amp version: meprednisone

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved