Nadifloxacin

Suppliers

Names

[ Name ]:
Nadifloxacin

[Synonym ]:
9-Fluoro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid
(±)-9-Fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic Acid
Nadiflox
Activon
1H,5H-Benzo[ij]quinolizine-2-carboxylic acid, 9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-
Acuatim
Jinofloxacin
Nadifloxacin
9-Fluoro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid
Nadixa
Nadoxin
MFCD00865081

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
624.9±55.0 °C at 760 mmHg

[ Melting Point ]:
245-247ºC (dec)

[ Molecular Formula ]:
C₁₉H₂₁FN₂O₄

[ Molecular Weight ]:
360.379

[ Flash Point ]:
331.7±31.5 °C

[ Exact Mass ]:
360.148529

[ PSA ]:
82.77000

[ LogP ]:
1.95

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.669

[ Storage condition ]:
-20?C Freezer

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

6-Fluoro-2-methylquinoline
5-Bromo-6-fluoro-2-Methylquinoline
4-Piperidinol
9-fluoro-8-bromo-5-methyl-6,7-dihydro-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid
Quinoline, 5-bromo-6-fluoro-1,2,3,4-tetrahydro-2-Methyl-

DownStream

Articles

Efficacy and safety of nadifloxacin for bacterial skin infections: results from clinical and post-marketing studies.

Dermatol. Ther. (Heidelb.) 4(2) , 233-48, (2014)

Skin and soft tissue infections involve microbial invasion of the skin and underlying soft tissues and are estimated to affect 7-10% of hospitalized patients worldwide. Nadifloxacin, a topical fluoroq...

Green Nail Syndrome (Pseudomonas aeruginosa Nail Infection): Two Cases Successfully Treated with Topical Nadifloxacin, an Acne Medication.

Case Rep. Dermatol. 6(2) , 180-4, (2014)

Green nail syndrome (GNS) caused by Pseudomonas aeruginosa is the most common bacterial nail infection. The treatment of GNS is challenging in many cases and recommendations based on clinical trials a...

Design and evaluation of microemulsion gel system of nadifloxacin.

Indian J. Pharm. Sci. 74(3) , 237-47, (2012)

Topical microemulsion systems for the antiacne agent, nadifloxacin were designed and developed to overcome the problems associated with the cutaneous delivery due to poor water solubility. The solubil...

R-Nadifloxacin
Levonadifloxacin
Nadifloxacin isomer 1
Nadifloxacin isomer 2
2-(1-Chloro-2-oxopropyl)-6-mercaptophenylacetic acid
2-(1-Chloro-2-oxopropyl)-6-nitrophenylacetonitrile
2-(2-(Trifluoromethoxy)phenyl)pyrimidine-5-acetonitrile
2-(1-Chloro-2-oxopropyl)-6-iodocinnamic acid
2-(1-Chloro-2-oxopropyl)-6-methoxycinnamic acid
2-(1-Chloro-2-oxopropyl)-6-formylcinnamic acid
2-(1-Chloro-2-oxopropyl)-6-formylphenylacetic acid
2-(1-Chloro-2-oxopropyl)-6-hydroxycinnamic acid
2-(1-Chloro-2-oxopropyl)-6-nitrocinnamic acid
2-(2-(Trifluoromethoxy)phenyl)thiazole-5-sulfonyl chloride

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