Pleuromutilin
Suppliers
Names
[ CAS No. ]:
125-65-5
[ Name ]:
Pleuromutilin
[Synonym ]:
Acetic acid, 2-hydroxy-, 6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester
Pleuromulin
Valnemulin impurity E
5-Hydroxy-4,6,9,10-tetramethyl-1-oxo-6-vinyldecahydro-3a,9-propanocyclopenta[8]annulen-8-yl hydroxyacetate
Drosophilin B,Mutilin 14-glycolate
EINECS 204-747-5
3-Hydroxy-2,4,7,14-tetramethyl-9-oxo-4-vinyltricyclo[5.4.3.0]tetradec-6-yl glycolate
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
482.8±45.0 °C at 760 mmHg
[ Melting Point ]:
170-171ºC
[ Molecular Formula ]:
C22H34O5
[ Molecular Weight ]:
378.502
[ Flash Point ]:
158.7±22.2 °C
[ Exact Mass ]:
378.240631
[ PSA ]:
83.83000
[ LogP ]:
2.63
[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C
[ Index of Refraction ]:
1.538
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- MC5408000
- CHEMICAL NAME :
- Glycolic acid, 8-ester with octahydro-5,8-dihydroxy-4,6,9,10-tetramethyl-6-vinyl- 3a,9- propano-3aH-cyclopentacycloocten-1(4H)-one
- CAS REGISTRY NUMBER :
- 125-65-5
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C22-H34-O5
- MOLECULAR WEIGHT :
- 378.56
- WISWESSER LINE NOTATION :
- T568/EN 2AE N BV EXTJ H1 I1 JOV1Q L1U1 L1 MQ N1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 60 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 6,123,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 6,123,1981
Safety Information
[ Hazard Codes ]:
Xi
[ RIDADR ]:
NONH for all modes of transport
[ RTECS ]:
MC5408000
[ HS Code ]:
2918199090
Synthetic Route
Customs
[ HS Code ]: 2918199090
[ Summary ]:
2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%
Articles
Antimicrob. Agents Chemother. 53 , 3589-91, (2009)
A novel ABC transporter gene, vga(C), was identified on the 14,365-bp multiresistance plasmid pKKS825 in a porcine methicillin (meticillin)-resistant Staphylococcus aureus isolate of sequence type 398...
Arch. Pharm. (Weinheim) 345(8) , 638-46, (2012)
A series of novel pleuromutilin derivatives containing the amino thiazolyl ring were designed, synthesized, and evaluated for their antibacterial activities in vitro against Gram-positive clinical bac...
Mol. Microbiol. 71(5) , 1218-27, (2009)
Tiamulin and valnemulin target the peptidyl transferase centre (PTC) on the bacterial ribosome. They are used in veterinary medicine to treat infections caused by a variety of bacterial pathogens, inc...