Siomycin A

Suppliers

Names

[ Name ]:
Siomycin A

[Synonym ]:
siomycin A
Antibiotic 6741-21,Mutabillicin,Mutabilycin
(1-L-valine)-[2-(2,3-didehydro-alanine)]-thiostrepton
N-{3-[(3-Amino-3-oxo-1-propen-2-yl)amino]-3-oxo-1-propen-2-yl}-2-[(11Z)-18-(2,3-dihydroxy-2-butanyl)-11-ethylidene-59-hydroxy-8,31-bis(1-hydroxyethyl)-37-isopropyl-26,46-dimethyl-40,43-bis(methylene)- ;6,9,16,23,28,38,41,44,47-nonaoxo-27-oxa-3,13,20,56-tetrathia-7,10,17,24,36,39,42,45,48,52,58,61,62,63,64-pentadecaazanonacyclo[23.23.9.3.1.1.1.1.0.0]tetra hexaconta-2(64),4,12(63),19(62),21,29,31,33,

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Molecular Formula ]:
C₇₁H₈₁N₁₉O₁₈S₅

[ Molecular Weight ]:
1648.844

[ Exact Mass ]:
1647.461060

[ PSA ]:
701.00000

[ LogP ]:
-8.95

[ Index of Refraction ]:
1.773

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

A novel mode of FoxM1 regulation: positive auto-regulatory loop.

Cell Cycle 8(12) , 1966-7, (2009)

Oncogenic transcription factor FoxM1 represents an attractive therapeutic target in the fight against cancer, because it is overexpressed in a majority of human tumors. Previously, we identified the t...

Thiazole antibiotics target FoxM1 and induce apoptosis in human cancer cells.

PLoS ONE 4(5) , e5592, (2009)

Forkhead box M1 (FoxM1) oncogenic transcription factor represents an attractive therapeutic target in the fight against cancer, because it is overexpressed in a majority of human tumors. Recently, usi...

The maternal embryonic leucine zipper kinase (MELK) is upregulated in high-grade prostate cancer.

J. Mol. Med. 91(2) , 237-48, (2013)

Loss of cell cycle control is a prerequisite for cancer onset and progression. In prostate cancer, increased activity of cell cycle genes has been associated with prognostic parameters such as biochem...