1-Chloro-2-propanol

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Names

[ CAS No. ]:
127-00-4

[ Name ]:
1-Chloro-2-propanol

[Synonym ]:
.α.-Propylene chlorohydrin
2-Propanol, 1-chloro-
sec-Propylene Chlorohydrin
EINECS 204-819-6
1-Chloro-2-propanol
Chloropropanol,Propylene chlorohydrin
Propylene chlorohydrin
UNII:ZL0FUS96WW
MFCD00004530

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
126.5±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C3H7ClO

[ Molecular Weight ]:
94.540

[ Flash Point ]:
54.5±15.3 °C

[ Exact Mass ]:
94.018539

[ PSA ]:
20.23000

[ LogP ]:
0.27

[ Vapour Pressure ]:
5.4±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.424

[ Stability ]:
Stable. Flammable. Incompatible with strong oxidizing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UA8942000
CHEMICAL NAME :
2-Propanol, 1-chloro-
CAS REGISTRY NUMBER :
127-00-4
BEILSTEIN REFERENCE NO. :
0773653
LAST UPDATED :
199712
DATA ITEMS CITED :
10
MOLECULAR FORMULA :
C3-H7-Cl-O
MOLECULAR WEIGHT :
94.55
WISWESSER LINE NOTATION :
QY1&1G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1000 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TEST SYSTEM :
Insect - Drosophila melanogaster
DOSE/DURATION :
1 ppb
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 23,51,1994

Safety Information

[ Symbol ]:

GHS02, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H226-H301 + H331-H315-H319-H335

[ Precautionary Statements ]:
Missing Phrase - N15.00950417-P210-P261-P304 + P340 + P312-P370 + P378-P403 + P233

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R10

[ Safety Phrases ]:
26-36/39

[ RIDADR ]:
UN 2611 6

[ WGK Germany ]:
3

[ RTECS ]:
UA8942000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1

[ HS Code ]:
2905590090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Epichlorohydrin
  • 1-Chloropropane
  • epoxypropane
  • Propylene Glycol
  • Octanoic acid
  • Ethylene glycol
  • Chloroacetone
  • Methanol
  • 3-Chloro-1-propanol
  • ALLYL CHLORIDE

DownStream

  • 1-(3-METHYL-BENZOFURANYL)-ETHANONE
  • UNII:ZL0FUS96WW
  • 1-(4-Methoxyphenoxy)-2-propanol
  • 1-(Diethylamino)-2-propanol
  • 1-(2-Methylphenoxy)-2-propanol
  • 1,1,3-Trichloroacetone
  • 2-Propanol,1-hydrazinyl-
  • Propylene Glycol
  • 1-(butylamino)propan-2-ol
  • 2-Propanol,1-[4-(1,1-dimethylethyl)phenoxy]-

Customs

[ HS Code ]: 2905590090

[ Summary ]:
2905590090 other halogenated, sulphonated, nitrated or nitrosated derivatives of acyclic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Articles

NTP Toxicology and Carcinogenesis Studies of 1-Chloro-2-propanol (Technical Grade) (CAS NO. 127-00-4) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies.

Natl. Toxicol. Program Tech. Rep. Ser. 477 , 1-264, (1998)

1-Chloro-2-propanol and its positional isomer, 2-chloro-1-propanol, are used as chemical intermediates for the manufacture of propylene oxide, a starting material for production of polyurethane polyol...

Chemical mutagenesis testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program.

Environ. Mol. Mutagen. 23(1) , 51-63, (1994)

Fifty chemicals were tested for mutagenic activity in post-meiotic and meiotic germ cells of male Drosophila melanogaster using the sex-linked recessive lethal (SLRL) assay. As in the previous studies...

Haloperoxidases: Enzymatic Synthesis of alpha,beta-Halohydrins from Gaseous Alkenes.

Appl. Environ. Microbiol. 45(2) , 366-74, (1983)

The enzymatic synthesis of alpha,beta-halohydrins from gaseous alkenes is described. The enzymatic reaction required an alkene, a halide ion, dilute hydrogen peroxide, and a haloperoxidase enzyme. A w...


More Articles

Related Compounds

  • 1-Chloro-2-propanol
  • 1-Chloro-2-propanol
  • 1-Chloro-2-propanol
  • 1-Chloro-2-propanol
  • 1-Chloro-2-propanol
  • 1-Chloro-2-propanol
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