Hydroxyurea

Suppliers

Names

[ CAS No. ]:
127-07-1

[ Name ]:
Hydroxyurea

[Synonym ]:
hydroxycarbamide
HYDROXYUREA (HYDROXYCARBAMIDE)
HYDROXYUREA 127-07-1
Hydroxyurea
Droxia
HYDROXYCARBAMIDE, BP STANDARD
HYDROXYHARNSTOFF
amino-hydroxamic acid
Hydrea
HYDROXYHARNSTOFF(HYDROXYUREA)
1-hydroxyure
hydroxyl urea
Hydroxy urea
HYDROXYCARBAMIDE (HYDROXYUREA)
MFCD00007943
Urea, N-hydroxy-
Onco-carbide
Oxyurea
N-HYDROXYUREA
EINECS 204-821-7
Litalir
1-Hydroxyurea
Biosupressin
hydroxyure

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
222.1±23.0 °C at 760 mmHg

[ Melting Point ]:
135-140 °C

[ Molecular Formula ]:
CH4N2O2

[ Molecular Weight ]:
76.055

[ Flash Point ]:
88.1±22.6 °C

[ Exact Mass ]:
76.027275

[ PSA ]:
75.35000

[ LogP ]:
-1.80

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.501

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
soluble

MSDS

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H340-H361

[ Precautionary Statements ]:
P201-P280-P308 + P313

[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T:Toxic

[ Risk Phrases ]:
R46;R61

[ Safety Phrases ]:
S53-S36/37-S45

[ RIDADR ]:
2811

[ WGK Germany ]:
3

[ RTECS ]:
YT4900000

[ Packaging Group ]:
III

[ HS Code ]:
2928000090

Synthetic Route

Precursor & DownStream

Precursor

  • N-(trimethylsiloxy)-N,N'-bis(trimethylsilyl)urea
  • Urea
  • ISOCYANIC ACID
  • Potassium cyanate
  • Urethane
  • N-carbethoxyphthalimide
  • L-Cysteine,S-(aminocarbonyl)-
  • trimethylsilyl isocyanate
  • HYDROXYLAMINE NITRATE

DownStream

  • 2-Butenedioic acid,2-bromo-, 1,4-dimethyl ester, (2Z)-
  • Methyl 3-hydroxyisoxazole-5-carboxylate
  • 2-Oxa-3-azabicyclo[2.2.1]hept-5-ene-3-carboxamide(9CI)
  • ureidoxymaleate de methyle
  • ureidoxyfumarate de methyle
  • 4-METHYLISOXAZOL-3-AMINE
  • Benzyloxyurea
  • Carbon dioxide
  • Ammonia
  • Urea

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Rad23 interaction with the proteasome is regulated by phosphorylation of its ubiquitin-like (UbL) domain.

J. Mol. Biol. 426(24) , 4049-60, (2014)

Rad23 was identified as a DNA repair protein, although a role in protein degradation has been described. The protein degradation function of Rad23 contributes to cell cycle progression, stress respons...

A gemcitabine sensitivity screen identifies a role for NEK9 in the replication stress response.

Nucleic Acids Res. 42(18) , 11517-27, (2014)

The Replication Stress Response (RSR) is a signaling network that recognizes challenges to DNA replication and coordinates diverse DNA repair and cell-cycle checkpoint pathways. Gemcitabine is a nucle...

Celastrol induces proteasomal degradation of FANCD2 to sensitize lung cancer cells to DNA crosslinking agents.

Cancer Sci. 106 , 902-8, (2015)

The Fanconi anemia (FA) pathway plays a key role in interstrand crosslink (ICL) repair and maintenance of the genomic stability, while inhibition of this pathway may sensitize cancer cells to DNA ICL ...


More Articles


Related Compounds

  • hydroxyurea
  • Methyl hydroxyurea
  • 3-ethyl-hydroxyurea
  • 3-Methylhydroxyurea
  • N3-phenyl hydroxyurea
  • 1-amino-3-hydroxyurea
  • 5-Bromo-2-[(4-methoxypiperidin-4-yl)methyl]pyridine
  • 3-(2-Ethoxypropyl)piperidin-3-ol
  • 3-[(Azetidin-3-yl)methyl]-1lambda6-thiolane-1,1-dione
  • 4-[(4-Methyl-1,3-thiazol-5-yl)methyl]piperidin-4-ol
  • 5-(1-Amino-3-hydroxycyclobutyl)thiophene-3-carbonitrile
  • 3-[3-(methoxycarbonyl)-1-methyl-1H-pyrazol-4-yl]-2,2-dimethylpropanoic acid
  • 4-Amino-4-(3-fluoro-2-methylphenyl)cyclohexan-1-ol
  • 2-Hydroxy-3-methyl-3-[3-(methylsulfanyl)phenyl]butanoic acid
  • 1-Fluoro-3-(2,4,6-trimethylphenyl)propan-2-ol
  • 1-[(3,4-dihydro-2H-pyran-5-yl)methyl]cyclopropan-1-amine