Pregnanolone
Suppliers
Names
[ CAS No. ]:
128-20-1
[ Name ]:
Pregnanolone
[Synonym ]:
MFCD00067137
Pregnanolone II
5-Pregnan-3-ol-20-one
pregnanalone
Pregnan-20-one, 3-hydroxy-, (3α)-
PREGNAN-3A-OL-20-ONE
3alpha-hydroxy-5beta-pregnan-20-one
(3α)-3-Hydroxypregnan-20-one
Pregnan-20-one,3-hydroxy-, (3a,5b)-
Butabindide oxalate
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
431.2±18.0 °C at 760 mmHg
[ Melting Point ]:
149ºC
[ Molecular Formula ]:
C21H34O2
[ Molecular Weight ]:
318.493
[ Flash Point ]:
183.9±13.8 °C
[ Exact Mass ]:
318.255890
[ PSA ]:
37.30000
[ LogP ]:
4.89
[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C
[ Index of Refraction ]:
1.524
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TU4384000
- CHEMICAL NAME :
- 5-beta-Pregnan-20-one, 3-alpha-hydroxy-
- CAS REGISTRY NUMBER :
- 128-20-1
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C21-H34-O2
- MOLECULAR WEIGHT :
- 318.55
- WISWESSER LINE NOTATION :
- L E5 B666TJ A1 E1 FV1 OQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 27500 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 11,117,1968
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 66 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 11,117,1968
Safety Information
[ Symbol ]:
GHS08
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H351
[ Precautionary Statements ]:
P281
[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ Hazard Codes ]:
Xn: Harmful;
[ Risk Phrases ]:
R40
[ Safety Phrases ]:
22-36
[ RIDADR ]:
NONH for all modes of transport
[ RTECS ]:
TU4384000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
J. Chromatogr. A. 1371 , 184-95, (2014)
Recently, hydroxy sterols and bile acids have gained growing interest as they are important regulators of energy homoeostasis and inflammation. The high number of different hydroxy sterols and bile ac...
Mol. Pharmacol. 86(6) , 635-46, (2014)
A critical obstacle to developing effective medications to prevent and/or treat alcohol use disorders is the lack of specific knowledge regarding the plethora of molecular targets and mechanisms under...
Psychopharmacol. Ser. 231(17) , 3401-14, (2014)
The rapid membrane actions of neuroactive steroids, particularly via an enhancement of γ-aminobutyric acidA receptors (GABAARs), participate in the regulation of central nervous system excitability. P...