Pregnanolone
Modify Date: 2024-01-08 03:39:52
Pregnanolone structure
|
Common Name | Pregnanolone | ||
|---|---|---|---|---|
| CAS Number | 128-20-1 | Molecular Weight | 318.493 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 431.2±18.0 °C at 760 mmHg | |
| Molecular Formula | C21H34O2 | Melting Point | 149ºC | |
| MSDS | Chinese USA | Flash Point | 183.9±13.8 °C | |
| Symbol |
GHS08 |
Signal Word | Warning | |
Use of PregnanolonePregnanolone, also known as 3a5b-Pregnanolone; Kabi-2213, SKF 6455, Eltanolone, is a cell membrane modulator potentially for the treatment of pain. Pregnanolone is an endogenous neurosteroid that is biosynthesized from progesterone. It is a positive allosteric modulator of the GABAA receptor, as well as a negative allosteric modulator of the glycine receptor, and is known to have sedative, anxiolytic, anesthetic, and anticonvulsant effects. It was investigated for clinical use as a general anesthetic, but produced unwanted side effects such as convulsions on occasion, and for that reason was never marketed. |
| Name | 3α-hydroxy-5β-pregnan-20-one |
|---|---|
| Synonym | More Synonyms |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 431.2±18.0 °C at 760 mmHg |
| Melting Point | 149ºC |
| Molecular Formula | C21H34O2 |
| Molecular Weight | 318.493 |
| Flash Point | 183.9±13.8 °C |
| Exact Mass | 318.255890 |
| PSA | 37.30000 |
| LogP | 4.89 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Index of Refraction | 1.524 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Symbol |
GHS08 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H351 |
| Precautionary Statements | P281 |
| Personal Protective Equipment | Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R40 |
| Safety Phrases | 22-36 |
| RIDADR | NONH for all modes of transport |
| RTECS | TU4384000 |
| Precursor 8 | |
|---|---|
| DownStream 4 | |
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| MFCD00067137 |
| Pregnanolone II |
| 5-Pregnan-3-ol-20-one |
| pregnanalone |
| Pregnan-20-one, 3-hydroxy-, (3α)- |
| PREGNAN-3A-OL-20-ONE |
| 3alpha-hydroxy-5beta-pregnan-20-one |
| (3α)-3-Hydroxypregnan-20-one |
| Pregnan-20-one,3-hydroxy-, (3a,5b)- |
| Butabindide oxalate |