5-Chloro-8-hydroxyquinoline

Suppliers

Names

[ CAS No. ]:
130-16-5

[ Name ]:
5-Chloro-8-hydroxyquinoline

[Synonym ]:
5-Chloro-8-hydroxy quinoline
5-chloroquinolin-8-ol
5-Chloroquinophenol
cloxiquine
5-Chlorooxine
EINECS 204-978-1
5-Chloro-8-quinolinol
5-Chloro-8-hydroxyquinoline
5-Chloro-quinolin-8-ol
8-Quinolinol, 5-chloro-
Dermofungin
quinolin-8-ol, 5-chloro-
5-Chloro-8-oxyquinoline
MFCD00006788
5-Chloro-8-oxychinolin
cloxyquin
5-CHLORO-8-HYDROXY-QUINOLINE

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
348.7±22.0 °C at 760 mmHg

[ Melting Point ]:
122-124 °C(lit.)

[ Molecular Formula ]:
C9H6ClNO

[ Molecular Weight ]:
179.603

[ Flash Point ]:
164.7±22.3 °C

[ Exact Mass ]:
179.013794

[ PSA ]:
33.12000

[ LogP ]:
3.02

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.697

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VC4590000
CHEMICAL NAME :
8-Quinolinol, 5-chloro-
CAS REGISTRY NUMBER :
130-16-5
BEILSTEIN REFERENCE NO. :
0005289
LAST UPDATED :
199701
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C9-H6-Cl-N-O
MOLECULAR WEIGHT :
179.61
WISWESSER LINE NOTATION :
T66 BNJ GG JQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
1200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation test systems - not otherwise specified
TEST SYSTEM :
Bacteria - Escherichia coli
DOSE/DURATION :
1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 307,141,1994

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
VC4590000

[ HS Code ]:
2933499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Clioquinol
  • 5-Bromo-8-quinolinol
  • 5-chloro-7-iodoquinolin-8-yl ethanoate
  • Glycerol
  • 2-Amino-4-chlorophenol
  • 5-chloro-8-quinolinyl-β-D-glucopyranoside
  • o-Nitrophenol
  • 2,3-dichloropropionaldehyde
  • Chloroxine

DownStream

  • 7-Quinolinecarboxylicacid,5-chloro-8-hydroxy-(9CI)
  • 5-chloro-7-nitro-quinolin-8-ol
  • Cloquintocet-mexyl
  • 7-Bromo-5-chloro-8-quinolinol
  • 5-CHLORO-7-DIMETHYLAMINOMETHYL-QUINOLIN-8-OL
  • 5-chloro-7-(diethylaminomethyl)quinolin-8-ol
  • Clioquinol
  • 5-Chloro-8-Methoxy-quinoline
  • 5-chloro-8-quinolinetrifluoromethanesul&
  • 5-chloro-8-(2,2-diethoxyethoxy)quinoline

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Identifying chelators for metalloprotein inhibitors using a fragment-based approach.

J. Med. Chem. 54 , 591-602, (2011)

Fragment-based lead design (FBLD) has been used to identify new metal-binding groups for metalloenzyme inhibitors. When screened at 1 mM, a chelator fragment library (CFL-1.1) of 96 compounds produced...

Photoluminescence and thermoanalytical studies of complexes based on 5-Cl-8-hydroxyquinoline and calix[4]arene ligands.

Mater. Sci. Eng. C. Mater. Biol. Appl. 33(4) , 2213-20, (2013)

A innovative 5-Cl-8-oxyquinolinepropoxycalix[4]arene ligand (2) have been prepared, exhibiting, at room temperature, blue fluorescent light emission and resulting in shift band to green fluorescent li...

Poly(L-lactide) and poly(butylene succinate) immiscible blends: from electrospinning to biologically active materials.

Mater. Sci. Eng. C. Mater. Biol. Appl. 41 , 119-26, (2014)

For the first time the preparation of defect-free fibers from immiscible blends of high molar mass poly(lactic acid) (PLA) and poly(butylene succinate) (PBS) in the whole range of the polyester weight...


More Articles

Related Compounds

  • 7-amino-5-chloro-8-hydroxyquinoline
  • 7-Bromo-5-chloro-8-hydroxyquinoline
  • 5-chloro-8-hydroxyquinoline-7-carbaldehyde
  • 5-Chloro-8-hydroxyquinoline-7-carboxylicacid
  • 5-chloro-8-methylsulfanyl-9-thia-2,4,7-triazabicyclo[4.3.0]nona-2,4,7,10-tetraene
  • 5-Chloro-8-methylquinoline
  • 2-(2-fluoropropan-2-yl)-1H-1,3-benzodiazole
  • 3-[2-(4-Fluorophenyl)ethyl]-1,2-oxazol-5-amine
  • 2-[1-(2-Methoxyphenyl)cyclopropyl]acetic acid
  • 2-[1-(3-Methoxyphenyl)cyclopropyl]acetic acid
  • 2-[1-(4-Methoxyphenyl)cyclopropyl]acetic acid
  • 6-Ethyl-3,4-dihydro-2H-1-benzopyran-4-carboxylic acid
  • 5,5-Difluoropent-1-yne
  • 3-(2,4-Dimethylphenyl)-2,2-dimethylpropanoic acid
  • 7-bromo-2-chloro-1H-indole
  • 5-cyclopropyl-1-(2-fluorophenyl)-1H-pyrazole-3-carboxylic acid