Pamoic acid
Suppliers
Names
[ CAS No. ]:
130-85-8
[ Name ]:
Pamoic acid
[Synonym ]:
Pamoic
1,1'-Methylene-bis(2-hydroxy-3-naphthoic acid)
2-Naphthalenecarboxylic acid, 4,4'-methylenebis[3-hydroxy-
4,4-Methylenebis(3-Hydroxy-2-Naphthoic Acid)
EMBIONIC ACID
PAMOIC ACID FREE ACID
2,2'-Dihydroxy-1,1'-dinaphthylmethane-3,3'-dicarboxylic Acid
4,4'-Methylenebis(3-hydroxy-2-naphthoic acid)
Pamoic acid
PAMOIC ACID pure
Embonic acid
4,4'-Methylenedi(3-hydroxy-2-naphthoic Acid)
EINECS 204-998-0
MFCD00004079
Chemical & Physical Properties
[ Density]:
1.5±0.1 g/cm3
[ Boiling Point ]:
642.7±55.0 °C at 760 mmHg
[ Melting Point ]:
≥300 °C (dec.)
[ Molecular Formula ]:
C23H16O6
[ Molecular Weight ]:
388.38
[ Flash Point ]:
356.5±28.0 °C
[ Exact Mass ]:
388.094696
[ PSA ]:
115.06000
[ LogP ]:
6.35
[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C
[ Index of Refraction ]:
1.782
[ Water Solubility ]:
PRACTICALLY INSOLUBLE
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QL2180000
- CHEMICAL NAME :
- 2-Naphthoic acid, 4,4'-methylenebis(3-hydroxy-
- CAS REGISTRY NUMBER :
- 130-85-8
- BEILSTEIN REFERENCE NO. :
- 0901319
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C23-H16-O6
- MOLECULAR WEIGHT :
- 388.39
- WISWESSER LINE NOTATION :
- L66J CQ DVQ B1- BL66J CQ DVQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,573,1982
- TYPE OF TEST :
- Rinsed with water
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,573,1982 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 390 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 13,381,1978
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi:Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S36
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
QL2180000
[ HS Code ]:
2917399090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2918290000
[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%
Articles
Pharm. Res. 31(8) , 2065-77, (2014)
Long-acting injectables (LAIs) are increasingly recognized as an effective therapeutic approach for treating chronic conditions. Many LAIs are formulated to create a poorly soluble depot from which th...
Proc. Natl. Acad. Sci. U. S. A. 101 , 17622-17627, (2004)
Phosphorylation of the cAMP response element binding protein (CREB) at Ser-133 in response to hormonal stimuli triggers cellular gene expression via the recruitment of the histone acetylase coactivato...
Mol. Pharm. 10(1) , 319-28, (2013)
We present an in situ hydrophobic salt forming technique for the encapsulation of weakly hydrophobic, ionizable active pharmaceutical ingredients (API) into stable nanocarriers (NCs) formed via a rapi...