Pamoic acid

Modify Date: 2024-01-02 07:28:11

Pamoic acid structure	Common Name	Pamoic acid
	CAS Number	130-85-8	Molecular Weight	388.38
	Density	1.5±0.1 g/cm3	Boiling Point	642.7±55.0 °C at 760 mmHg
	Molecular Formula	C₂₃H₁₆O₆	Melting Point	≥300 °C (dec.)
	MSDS	Chinese USA	Flash Point	356.5±28.0 °C
	Symbol	GHS07	Signal Word	Warning

Use of Pamoic acid

Pamoic acid is a potent GPR35 agonist with an EC50 of 79 nM. Pamoic acid exhibits neuroprotective and anti-inflammatory properties[1][2].

Name	pamoic acid
Synonym	More Synonyms

Description	Pamoic acid is a potent GPR35 agonist with an EC50 of 79 nM. Pamoic acid exhibits neuroprotective and anti-inflammatory properties[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> MAPK/ERK Pathway >> ERK Research Areas >> Neurological Disease Signaling Pathways >> Stem Cell/Wnt >> ERK
Target	EC50: 79 nM (GPR35)[1]
In Vitro	GPR35 activation by Pamoic acid may increase the phosphorylation of ERK1/2, which in turn initiates an anti-inflammatory signal by suppressing NF-κB-dependent inflammatory genes[1].
In Vivo	In a mouse model of stroke, that GPR35 activation by Pamoic acid (s.c.; 50-100 mg/kg) is neuroprotective. Pharmacological inhibition of GPR35 reveals that Pamoic acid reduces infarcts size in a GPR35 dependent manner. Pamoic acid treatment results in a preferential increment of noninflammatory Ly-6CLo monocytes/macrophages in the ischemic brain along with the reduced neutrophil counts[1].
References	[1]. Ozayra Sharmin, et al. Activation of GPR35 protects against cerebral ischemia by recruiting monocyte-derived macrophages. Sci Rep. 2020 Jun 10;10(1):9400. [2]. Pingwei Zhao, et al. Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Mol Pharmacol. 2010 Oct;78(4):560-8.

Density	1.5±0.1 g/cm3
Boiling Point	642.7±55.0 °C at 760 mmHg
Melting Point	≥300 °C (dec.)
Molecular Formula	C₂₃H₁₆O₆
Molecular Weight	388.38
Flash Point	356.5±28.0 °C
Exact Mass	388.094696
PSA	115.06000
LogP	6.35
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.782
Water Solubility	PRACTICALLY INSOLUBLE

Pamoic acid MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QL2180000

CHEMICAL NAME :: 2-Naphthoic acid, 4,4'-methylenebis(3-hydroxy-

CAS REGISTRY NUMBER :: 130-85-8

BEILSTEIN REFERENCE NO. :: 0901319

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C23-H16-O6

MOLECULAR WEIGHT :: 388.39

WISWESSER LINE NOTATION :: L66J CQ DVQ B1- BL66J CQ DVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,573,1982

TYPE OF TEST :: Rinsed with water

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,573,1982 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 390 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 13,381,1978

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	QL2180000
HS Code	2917399090

Formaldehyde

CAS#:50-00-0

3-Hydroxy-2-nap...

CAS#:92-70-6

~95%

Pamoic acid

CAS#:130-85-8

Literature: Journal of Organic Chemistry, , vol. 61, # 11 p. 3865 - 3869

Formaldehyde

CAS#:50-00-0

acetic acid

CAS#:64-19-7

3-Hydroxy-2-nap...

CAS#:92-70-6

Pamoic acid

CAS#:130-85-8

Literature: Chemische Berichte, , vol. 34, p. 4148 Chemische Berichte, , vol. 25, p. 3215 Chemische Berichte, , vol. 61, p. 1001

Precursor 3
CAS#:50-00-0 Formaldehyde CAS#:92-70-6 3-Hydroxy-2-nap... CAS#:64-19-7 acetic acid
DownStream 3
CAS#:6640-22-8 Pamoic acid disodium CAS#:10075-24-8 Imipramine pamoate CAS#:49609-90-7 methyl 3-methox...

HS Code	2918290000
Summary	HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

Long-acting atypical antipsychotics: characterization of the local tissue response.

Pharm. Res. 31(8) , 2065-77, (2014)

Long-acting injectables (LAIs) are increasingly recognized as an effective therapeutic approach for treating chronic conditions. Many LAIs are formulated to create a poorly soluble depot from which th...

Identification of small-molecule antagonists that inhibit an activator: coactivator interaction.

Proc. Natl. Acad. Sci. U. S. A. 101 , 17622-17627, (2004)

Phosphorylation of the cAMP response element binding protein (CREB) at Ser-133 in response to hormonal stimuli triggers cellular gene expression via the recruitment of the histone acetylase coactivato...

Formation of stable nanocarriers by in situ ion pairing during block-copolymer-directed rapid precipitation.

Mol. Pharm. 10(1) , 319-28, (2013)

We present an in situ hydrophobic salt forming technique for the encapsulation of weakly hydrophobic, ionizable active pharmaceutical ingredients (API) into stable nanocarriers (NCs) formed via a rapi...

Pamoic

1,1'-Methylene-bis(2-hydroxy-3-naphthoic acid)

2-Naphthalenecarboxylic acid, 4,4'-methylenebis[3-hydroxy-

4,4-Methylenebis(3-Hydroxy-2-Naphthoic Acid)

EMBIONIC ACID

PAMOIC ACID FREE ACID

2,2'-Dihydroxy-1,1'-dinaphthylmethane-3,3'-dicarboxylic Acid

4,4'-Methylenebis(3-hydroxy-2-naphthoic acid)

Pamoic acid

PAMOIC ACID pure

Embonic acid

4,4'-Methylenedi(3-hydroxy-2-naphthoic Acid)

EINECS 204-998-0

MFCD00004079

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Pamoic acid
Price: ￥118.0/25g ￥348.0/100g
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Pamoic acid
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Pamoic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Pamoic acid
Price: $Inquiry/1kg
Purity: 99.0%
Stocking Period: 1 Day
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Pamoic acid
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

Get all suppliers and price by the below link:

Pamoic acid suppliers

Price: ￥350/1 g

Reference only. check more Pamoic acid price

Pamoic acid

Use of Pamoic acid

Names

Pamoic acid Biological Activity

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

Synthetic Route

Precursor & DownStream

Customs

Articles22

Synonyms