Ethyl trifluoropyruvate

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Names

[ CAS No. ]:
13081-18-0

[ Name ]:
Ethyl trifluoropyruvate

[Synonym ]:
Ethyl 3,3,3-trifluoro-2-oxopropanoate
Ethyl trifluoropyruvate
Propanoic acid, 3,3,3-trifluoro-2-oxo-, ethyl ester
Trifluoropyruvic acid ethyl ester
Ethyl 2-oxo-3,3,3-trifluoropropanoate
Ethyl 3,3,3-trifluoropyruvate
MFCD00114935
FXFFVVO2
Ethyltrifluoropyruvate

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
88.1±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C5H5F3O3

[ Molecular Weight ]:
170.087

[ Flash Point ]:
8.1±22.2 °C

[ Exact Mass ]:
170.019073

[ PSA ]:
43.37000

[ LogP ]:
1.57

[ Vapour Pressure ]:
62.0±0.2 mmHg at 25°C

[ Index of Refraction ]:
1.349

[ Storage condition ]:
Refrigerator

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H226-H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US)

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R10;R36/37/38

[ Safety Phrases ]:
S26-S37/39-S16

[ RIDADR ]:
UN 3272 3/PG 3

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
3

[ HS Code ]:
2918300090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • ethyl 2-ethoxy-2,3,3,3-tetrafluoropropanoate
  • Bromotrifluoromethane (R 13B1)
  • Diethyloxalate
  • Ethanol
  • 3,3,3-trifluoro-2,2-dihydroxypropanoic acid
  • Hexafluoropropylene oxide

DownStream

  • Trifluoropyruvic acid 1-hydrate
  • 2-HYDROXY-3-(TRIFLUOROMETHYL)QUINOXALIN
  • ethyl 2-[tert-butoxycarbonylimino]-3,3,3-trifluoro-propionate
  • ethyl 2-benzoylimino-3,3,3-trifluoropropanoate
  • ETHYL 2-[BENZYLOXYCARBONYLIMINO]-3,3,3-TRIFLUORO-PROPIONATE
  • Benzenemethanol, a-(2-phenylethynyl)-
  • ethyl 2-hydroxy-2-(trifluoromethyl)-4-methylpent-4-enoate 97
  • (2R)-2-(5-amino-1,3,4-oxadiazol-2-yl)-1,1,1-trifluorobutan-2-ol
  • Ethyl 3,3,3-trifluoro-2-hydroxy-propionate

Customs

[ HS Code ]: 2918300090

[ Summary ]:
2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

Organocatalytic enantioselective Friedel–Crafts alkylation of simple phenols with trifluoropyruvate. Zhao JL, et al.

Tetrahedron Lett. 49(9) , 1476-1479, (2008)

Novel Enantiocomplementary C2-Symmetric Chiral Bis (imidazoline) Ligands: Highly Enantioselective Friedel–Crafts Alkylation of Indoles with Ethyl 3, 3, 3-Trifluoropyruvate. Nakamura S, et al.

Adv. Synth. Catal. 350(10) , 1443-1448, (2008)

Synthesis of N-Heteroaryl (trifluoromethyl) hydroxyalkanoic Acid Esters by Highly Efficient Solid Acid-Catalyzed Hydroxyalkylation of Indoles and Pyrroles with Activated Trifluoromethyl Ketones. Abid M and Török B.

Adv. Synth. Catal. 347(14) , 1797-1803, (2005)


More Articles

Related Compounds

  • ethyl trifluoropyruvate benzoylimine
  • ethyl 8-(4-fluorophenyl)-8-oxooctanoate
  • ETHYL 4-(3,4-DIMETHYLPHENYL)-4-OXOBUTYRATE
  • ethyl 3-(3-nitrophenyl)-4-oxopent-2-enoate
  • ETHYL 8-(1-NAPHTHYL)-8-OXOOCTANOATE
  • ETHYL 2-((TERT-BUTOXYCARBONYL)AMINO)THIAZOLE-5-CARBOXYLATE
  • rac-3-{N-benzyl-1-[(2R,3S)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)oxolan-2-yl]formamido}propanoic acid
  • 1-(4-Bromothiophen-2-yl)cyclobutan-1-amine
  • 3-{[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)oxolan-2-yl]formamido}-2-methylpropanoic acid
  • (2S)-2-{[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)oxolan-2-yl]formamido}butanoic acid
  • 2-{[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)oxolan-2-yl]formamido}-2-methylpropanoic acid
  • 2-[(2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-N-(2-hydroxyethyl)-4-methylpentanamido]acetic acid
  • 2-{1-[3-bromo-5-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)phenyl]-N-(2-hydroxyethyl)formamido}acetic acid
  • 2-[6-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-N-(2-hydroxyethyl)-4-methylhexanamido]acetic acid
  • 2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-N-(2-hydroxyethyl)-2-methylpentanamido]acetic acid
  • 2-{1-[1-benzyl-4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)piperidin-4-yl]-N-(butan-2-yl)formamido}acetic acid