Entacapone

Suppliers

Names

[ Name ]:
Entacapone

[Synonym ]:
(E)-2-Cyano-N,N-diethyl-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide
(2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylacrylamide
Comtan
Comtes
(2Z)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylacrylamide
OR-611
2-Cyano-N,N-diethyl-3-(3,4-dihydroxy-5-nitrophenyl)propenamide
MFCD00866580
2-Propenamide, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-, (2E)-
(2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide
Comtess
(E)-a-Cyano-N,N-diethyl-3,4-dihydroxy-5-nitrocinnamamide
Entacapone
2-Propenamide, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-, (2Z)-

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
526.6±50.0 °C at 760 mmHg

[ Melting Point ]:
162-1630C

[ Molecular Formula ]:
C₁₄H₁₅N₃O₅

[ Molecular Weight ]:
305.286

[ Flash Point ]:
272.3±30.1 °C

[ Exact Mass ]:
305.101166

[ PSA ]:
130.38000

[ LogP ]:
2.38

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.642

[ Storage condition ]:
-20°C Freezer

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xn,T,F

[ Risk Phrases ]:
R10:Flammable. R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . R37/38:Irritating to respiratory system and skin . R41:Risk of serious damage to eyes. R62:Possible risk of impaired fertility. R38:Irritating to the skin. R36/37/38:Ir

[ Safety Phrases ]:
S26-S36-S39-S45-S36/37/39-S16

[ RIDADR ]:
UN 1986 3/PG 3

[ WGK Germany ]:
1

[ RTECS ]:
KM5250000

[ Packaging Group ]:
III

[ Hazard Class ]:
3

[ HS Code ]:
2942000000

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2942000000

Articles

Dog UDP-glucuronosyltransferase enzymes of subfamily 1A: cloning, expression, and activity.

Drug Metab. Dispos. 43(1) , 107-18, (2014)

Understanding drug glucuronidation in the dog, a preclinical animal, is important but currently poorly characterized at the level of individual enzymes. We have constructed cDNAs for the 10 dog UDP-gl...

Comparison of IPX066 with carbidopa-levodopa plus entacapone in advanced PD patients.

Parkinsonism Relat. Disord. 20(12) , 1335-40, (2014)

IPX066, an investigational extended-release carbidopa-levodopa (CD-LD) preparation, has demonstrated a rapid attainment and prolonged maintenance of therapeutic LD plasma concentrations in advanced Pa...

Entacapone and prostate cancer risk in patients with Parkinson's disease.

Mov. Disord 30(5) , 724-8, (2015)

The association between Parkinson's disease (PD) and prostate cancer, both common in elderly men, is disputable. In the STRIDE-PD study, prostate cancer developed in 9 patients (3.7%) receiving levodo...

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