Entacapone
Entacapone structure
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Common Name | Entacapone | ||
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| CAS Number | 130929-57-6 | Molecular Weight | 305.286 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 526.6±50.0 °C at 760 mmHg | |
| Molecular Formula | C14H15N3O5 | Melting Point | 162-1630C | |
| MSDS | USA | Flash Point | 272.3±30.1 °C | |
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Dog UDP-glucuronosyltransferase enzymes of subfamily 1A: cloning, expression, and activity.
Drug Metab. Dispos. 43(1) , 107-18, (2014) Understanding drug glucuronidation in the dog, a preclinical animal, is important but currently poorly characterized at the level of individual enzymes. We have constructed cDNAs for the 10 dog UDP-glucuronosyltransferases of subfamily 1A (dUGT1As), expressed... |
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Comparison of IPX066 with carbidopa-levodopa plus entacapone in advanced PD patients.
Parkinsonism Relat. Disord. 20(12) , 1335-40, (2014) IPX066, an investigational extended-release carbidopa-levodopa (CD-LD) preparation, has demonstrated a rapid attainment and prolonged maintenance of therapeutic LD plasma concentrations in advanced Parkinson's disease (PD). This phase-3 crossover study assess... |
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Entacapone and prostate cancer risk in patients with Parkinson's disease.
Mov. Disord 30(5) , 724-8, (2015) The association between Parkinson's disease (PD) and prostate cancer, both common in elderly men, is disputable. In the STRIDE-PD study, prostate cancer developed in 9 patients (3.7%) receiving levodopa/carbidopa with entacapone, a catechol-O-methyltransferas... |
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Dopamine bioavailability in the mPFC modulates operant learning performance in rats: an experimental study with a computational interpretation.
Behav. Brain Res. 280 , 92-100, (2014) Dopamine encodes reward and its prediction in reinforcement learning. Catechol-O-methyltransferase (COMT) activity in the medial prefrontal cortex (mPFC) has been shown to influence cognitive abilities by modifying dopamine clearance. Nevertheless, it is unkn... |
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The blood-brain barrier-permeable catechol-O-methyltransferase inhibitor dinitrocatechol suppresses experimental autoimmune encephalomyelitis.
J. Neuroimmunol. 276(1-2) , 135-41, (2014) Reduced levels of noradrenaline (NA) in CNS of multiple sclerosis patients could be due to metabolism by catechol-O-methyltransferase (COMT). In mice immunized with myelin oligodendrocyte glycoprotein peptide, the BBB-permeable COMT inhibitor dinitrocatechol ... |