Pheniramine maleate

Suppliers

Names

[ CAS No. ]:
132-20-7

[ Name ]:
Pheniramine maleate

[Synonym ]:
(2Z)-But-2-endisäure--N,N-dimethyl-3-phenyl-3-pyridin-2-ylpropan-1-amin(1:1)
Pheniramine maleate
1-(N,N-Dimethylamino)-3-(phenyl-3-a-pyridyl)propane Maleate
N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine (2Z)-but-2-enedioate (1:1)
EINECS 205-051-4
3-Phenyl-3-(2-pyridyl)-N,N-dimethylpropylamine Maleate
N,N-dimethyl-3-phenyl-3-pyridin-2-ylpropan-1-amine (2Z)-but-2-enedioate
(Z)-but-2-enedioic acid,N,N-dimethyl-3-phenyl-3-pyridin-2-ylpropan-1-amine
Pheniramine maleate salt
2-Pyridinepropanamine, N,N-dimethyl-γ-phenyl-, (2Z)-2-butenedioate (1:1)
N,N-Dimethyl-3-phenyl-3-(2-pyridinyl)-1-propanamine (2Z)-2-butenedioate (1:1)
acide (2Z)-but-2-ènedioïque - N,N-diméthyl-3-phényl-3-pyridin-2-ylpropan-1-amine (1:1)
UNII:NYW905655B
Naphcon A
MFCD00079250

Chemical & Physical Properties

[ Boiling Point ]:
348.3ºC at 760 mmHg

[ Melting Point ]:
104-108°C

[ Molecular Formula ]:
C₂₀H₂₄N₂O₄

[ Molecular Weight ]:
356.416

[ Flash Point ]:
164.5ºC

[ Exact Mass ]:
356.173615

[ PSA ]:
90.73000

[ LogP ]:
2.87700

[ Vapour Pressure ]:
5.07E-05mmHg at 25°C

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
>=1 g/100 mL at 24 ºC

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UT0175000

CAS REGISTRY NUMBER :: 132-20-7

LAST UPDATED :: 199701

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C16-H20-N2.C4-H4-O4

MOLECULAR WEIGHT :: 356.46

WISWESSER LINE NOTATION :: T6NJ BYR&2N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - antipsychotic Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 520 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - changes in motor activity (specific assay) Behavioral - aggression

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 268 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - changes in motor activity (specific assay) Behavioral - aggression

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 111 mg/kg

TOXIC EFFECTS :: Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - respiratory stimulation

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 270 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 72 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 1120 ug/kg

REFERENCE :: IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 19,516,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83158 No. of Facilities: 1580 (estimated) No. of Industries: 3 No. of Occupations: 9 No. of Employees: 6126 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83158 No. of Facilities: 12 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 494 (estimated) No. of Female Employees: 206 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Precautionary Statements ]:
P301 + P312 + P330

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
UT0175000

Articles

Assessment of protective effects of methylprednisolone and pheniramine maleate on reperfusion injury in kidney after distant organ ischemia: a rat model.

Ann. Vasc. Surg. 26(4) , 559-65, (2012)

Ischemia/reperfusion (I/R) injury of tissues is a common problem that cardiovascular surgeons are faced with. Suppression of inflammation, which plays an important role in the pathogenesis of I/R inju...

Artificial neural network combined with principal component analysis for resolution of complex pharmaceutical formulations.

Chem. Pharm. Bull. 59(1) , 35-40, (2011)

A chemometric approach based on the combined use of the principal component analysis (PCA) and artificial neural network (ANN) was developed for the multicomponent determination of caffeine (CAF), mep...

C7a, a biphosphinic cyclopalladated compound, efficiently controls the development of a patient-derived xenograft model of adult T cell leukemia/lymphoma.

Viruses 3(7) , 1041-58, (2011)

Adult T-cell leukemia/lymphoma (ATLL) is a highly aggressive disease that occurs in individuals infected with the human T lymphotropic virus type 1 (HTLV-1). Patients with aggressive ATLL have a poor ...