Pheniramine maleate

Modify Date: 2025-08-20 15:00:47

Pheniramine maleate Structure
Pheniramine maleate structure
 Common Name Pheniramine maleate
CAS Number 132-20-7 Molecular Weight 356.416
Density N/A Boiling Point 348.3ºC at 760 mmHg
Molecular Formula C20H24N2O4 Melting Point 104-108°C
MSDS Chinese USA Flash Point 164.5ºC
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Pheniramine maleate


Pheniramine Maleate ia an antihistamine and vasoconstrictor.

 Names

Name Pheniramine Maleate
Synonym More Synonyms

 Pheniramine maleate Biological Activity

Description Pheniramine Maleate ia an antihistamine and vasoconstrictor.
Related Catalog

 Chemical & Physical Properties

Boiling Point 348.3ºC at 760 mmHg
Melting Point 104-108°C
Molecular Formula C20H24N2O4
Molecular Weight 356.416
Flash Point 164.5ºC
Exact Mass 356.173615
PSA 90.73000
LogP 2.87700
Vapour Pressure 5.07E-05mmHg at 25°C
InChIKey SSOXZAQUVINQSA-BTJKTKAUSA-N
SMILES CN(C)CCC(c1ccccc1)c1ccccn1.O=C(O)C=CC(=O)O
Stability Stable. Incompatible with strong oxidizing agents.
Water Solubility >=1 g/100 mL at 24 ºC

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UT0175000
CAS REGISTRY NUMBER :
132-20-7
LAST UPDATED :
199701
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C16-H20-N2.C4-H4-O4
MOLECULAR WEIGHT :
356.46
WISWESSER LINE NOTATION :
T6NJ BYR&2N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - child
DOSE/DURATION :
30 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - antipsychotic Lungs, Thorax, or Respiration - cyanosis
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
520 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - changes in motor activity (specific assay) Behavioral - aggression
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
268 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - changes in motor activity (specific assay) Behavioral - aggression
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
111 mg/kg
TOXIC EFFECTS :
Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - respiratory stimulation
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
270 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
72 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
1120 ug/kg
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 19,516,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83158 No. of Facilities: 1580 (estimated) No. of Industries: 3 No. of Occupations: 9 No. of Employees: 6126 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83158 No. of Facilities: 12 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 494 (estimated) No. of Female Employees: 206 (estimated)

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Precautionary Statements P301 + P312 + P330
Hazard Codes Xn: Harmful;
Risk Phrases R22
Safety Phrases S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS UT0175000

 Articles26

More Articles
Assessment of protective effects of methylprednisolone and pheniramine maleate on reperfusion injury in kidney after distant organ ischemia: a rat model.

Ann. Vasc. Surg. 26(4) , 559-65, (2012)

Ischemia/reperfusion (I/R) injury of tissues is a common problem that cardiovascular surgeons are faced with. Suppression of inflammation, which plays an important role in the pathogenesis of I/R inju...

Artificial neural network combined with principal component analysis for resolution of complex pharmaceutical formulations.

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C7a, a biphosphinic cyclopalladated compound, efficiently controls the development of a patient-derived xenograft model of adult T cell leukemia/lymphoma.

Viruses 3(7) , 1041-58, (2011)

Adult T-cell leukemia/lymphoma (ATLL) is a highly aggressive disease that occurs in individuals infected with the human T lymphotropic virus type 1 (HTLV-1). Patients with aggressive ATLL have a poor ...

 Pheniramine maleateBioassay

View more

Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN
Name: Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay
Source: ChEMBL
Target: N/A
External Id: CHEMBL1266185
Name: ERK5 transcriptional activity HTS
Source: 24565
Target: N/A
External Id: ERK5 transcriptional activity-HTS
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
Name: Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit...
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: N/A
External Id: HMS1315
Name: A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
External Id: HMS979
Name: Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
Source: Broad Institute
Target: FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id: 2147-01_Inhibitor_SinglePoint_HTS_Activity
Name: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect...
Source: Broad Institute
Target: N/A
External Id: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity
Name: Identifying Sarm1 Tir Hydrolase inhibitors through NAD-Glo assay
Source: 24386
Target: N/A
External Id: Sarm1 Tir NADase inhibitors screen
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 Synonyms

(2Z)-But-2-endisäure--N,N-dimethyl-3-phenyl-3-pyridin-2-ylpropan-1-amin(1:1)
Pheniramine maleate
1-(N,N-Dimethylamino)-3-(phenyl-3-a-pyridyl)propane Maleate
N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine (2Z)-but-2-enedioate (1:1)
EINECS 205-051-4
3-Phenyl-3-(2-pyridyl)-N,N-dimethylpropylamine Maleate
N,N-dimethyl-3-phenyl-3-pyridin-2-ylpropan-1-amine (2Z)-but-2-enedioate
(Z)-but-2-enedioic acid,N,N-dimethyl-3-phenyl-3-pyridin-2-ylpropan-1-amine
Pheniramine maleate salt
2-Pyridinepropanamine, N,N-dimethyl-γ-phenyl-, (2Z)-2-butenedioate (1:1)
N,N-Dimethyl-3-phenyl-3-(2-pyridinyl)-1-propanamine (2Z)-2-butenedioate (1:1)
acide (2Z)-but-2-ènedioïque - N,N-diméthyl-3-phényl-3-pyridin-2-ylpropan-1-amine (1:1)
UNII:NYW905655B
Naphcon A
MFCD00079250
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