Ibrolipim

Names

[ CAS No. ]:
133208-93-2

[ Name ]:
Ibrolipim

[Synonym ]:
Ibrolipim
NO 1886
OPF-009
Lipoprotein Lipase Activator

Chemical & Physical Properties

[ Density]:
1.44g/cm3

[ Boiling Point ]:
512.5ºC at 760 mmHg

[ Molecular Formula ]:
C₁₉H₂₀BrN₂O₄P

[ Molecular Weight ]:
451.25100

[ Flash Point ]:
263.7ºC

[ Exact Mass ]:
450.03400

[ PSA ]:
98.23000

[ LogP ]:
5.41218

[ Vapour Pressure ]:
1.29E-10mmHg at 25°C

[ Index of Refraction ]:
1.59

[ Storage condition ]:
2-8°C

MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310

[ RIDADR ]:
UN 2811 6.1 / PGIII

Articles

Effects of NO-1886 on inflammation-associated cytokines in high-fat/high-sucrose/high-cholesterol diet-fed miniature pigs.

Eur. J. Pharmacol. 540(1-3) , 139-46, (2006)

Inflammation, closely associated with obesity, is emerging as an important risk factor for the pathophysiological development of atherosclerosis and diabetes mellitus. Fat balance is critical in the a...

NO-1886 suppresses diet-induced insulin resistance and cholesterol accumulation through STAT5-dependent upregulation of IGF1 and CYP7A1.

J. Endocrinol. 1st ed., 204 , 47-56, (2010)

Insulin resistance and dyslipidemia are both considered to be risk factors for metabolic syndrome. Low levels of IGF1 are associated with insulin resistance. Elevation of low-density lipoprotein chole...

Evaluation of induction potency of new drug candidates on CYP1A2 and CYP3A4 using real-time one-step RT-PCR in primary cultures of cryopreserved human hepatocytes.

Drug Metab. Pharmacokinet. 24(5) , 446-50, (2009)

This study evaluates the induction potency of new drug candidates on mRNA levels of CYP1A2 and CYP3A4 in primary cultures of cryopreserved human hepatocytes. Analysis was performed by quantitative rea...