ACTINONIN

Suppliers

Names

[ Name ]:
ACTINONIN

[Synonym ]:
Butanediamide, N-hydroxy-N-[(1S)-1-[[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]-2-pentyl-, (2R)-
Actinonine
MFCD00080257
hylpropyl)carbamoyl)
(2R)-N-Hydroxy-N-{(2S)-1-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}-2-pentylsuccinamide
(2R)-N-Hydroxy-N-{(2S)-1-[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]-3-methyl-1-oxo-2-butanyl}-2-pentylsuccinamide

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Melting Point ]:
137-139ºC

[ Molecular Formula ]:
C₁₉H₃₅N₃O₅

[ Molecular Weight ]:
385.498

[ Exact Mass ]:
385.257660

[ PSA ]:
118.97000

[ LogP ]:
0.59

[ Index of Refraction ]:
1.513

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RG9900700

CHEMICAL NAME :: Octanohydroxamic acid, 3-((1-((2-(hydroxymethyl)-1-pyrrolidinyl)carbonyl)-2- methylpropyl) carbamoyl)-

CAS REGISTRY NUMBER :: 13434-13-4

LAST UPDATED :: 199512

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C19-H35-N3-O5

MOLECULAR WEIGHT :: 385.57

WISWESSER LINE NOTATION :: T5NTJ AVYY1&1&MVY5&1VMQ B1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 38,1629,1985

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,102,1967

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPXXDW European Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #167936

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
RG9900700

Articles

Proteome-wide analysis of the amino terminal status of Escherichia coli proteins at the steady-state and upon deformylation inhibition.

Proteomics 15 , 2503-18, (2015)

A proteome wide analysis was performed in Escherichia coli to identify the impact on protein N-termini of actinonin, an antibiotic specifically inhibiting peptide deformylase (PDF). A strategy and too...

Quality control of mitochondrial protein synthesis is required for membrane integrity and cell fitness.

J. Cell Biol. 211 , 373-89, (2015)

Mitochondrial ribosomes synthesize a subset of hydrophobic proteins required for assembly of the oxidative phosphorylation complexes. This process requires temporal and spatial coordination and regula...

Concanavalin-A-induced autophagy biomarkers requires membrane type-1 matrix metalloproteinase intracellular signaling in glioblastoma cells.

Glycobiology 22(9) , 1245-55, (2012)

Pre-clinical trials for cancer therapeutics support the anti-neoplastic properties of the lectin from Canavalia ensiformis (Concanavalin-A, ConA) in targeting apoptosis and autophagy in a variety of c...

actinonin
O-O-Dibenzyl-(-)-actinonin
2-[5-(2,2-Dimethylcyclopropanecarbonyl)-octahydropyrrolo[3,4-c]pyrrol-2-yl]-5-fluoropyridine
5-Chloro-2-[5-(oxane-2-carbonyl)-octahydropyrrolo[3,4-c]pyrrol-2-yl]pyridine
2-[3-cyclopropyl-6-fluoro-2,4-dioxo-7-(piperidin-1-yl)-1,2,3,4-tetrahydroquinazolin-1-yl]-N,N-dipropylacetamide
N-[(4-hydroxy-3,4-dihydro-1H-2-benzothiopyran-4-yl)methyl]-2,2-dimethylpropanamide
methyl N-{4-[(1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl}carbamate
methyl N-[(4-hydroxy-3,4-dihydro-1H-2-benzothiopyran-4-yl)methyl]carbamate
N-[(4-hydroxy-3,4-dihydro-1H-2-benzothiopyran-4-yl)methyl]-3,3-dimethylbutanamide
4,4,4-Trifluoro-1-[5-(5-fluoropyridin-2-yl)-octahydropyrrolo[3,4-c]pyrrol-2-yl]butan-1-one
5-Bromo-2-[5-(oxane-4-carbonyl)-octahydropyrrolo[3,4-c]pyrrol-2-yl]pyridine
5-Chloro-2-[5-(2,2-dimethylcyclopropanecarbonyl)-octahydropyrrolo[3,4-c]pyrrol-2-yl]pyridine

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