2-Naphthol

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Names

[ CAS No. ]:
135-19-3

[ Name ]:
2-Naphthol

[Synonym ]:
β-naphthol
β-Naphthyl alcohol
2-Naphthalenol
β-hydroxynaphthalene
Betanaphthol
EINECS 205-182-7
Naphthol B
2-Hydroxynaphthalene
b-Naphthol
Isonaphthol
Microcidin
Developer NA
2-Naphthol
MFCD00004067
b-Naphthyl alcohol
Developer BN
2-Napththol
naphthalen-2-ol
B-HYDROXYNAPHTHALENE

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
285.5±0.0 °C at 760 mmHg

[ Melting Point ]:
120-122 °C(lit.)

[ Molecular Formula ]:
C₁₀H₈O

[ Molecular Weight ]:
144.170

[ Flash Point ]:
144.0±10.6 °C

[ Exact Mass ]:
144.057510

[ PSA ]:
20.23000

[ LogP ]:
2.71

[ Vapour density ]:
4.97 (vs air)

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.678

[ Storage condition ]:
Refrigerator

[ Stability ]:
Stable. Combustible. Dust may form explosive mixture with air. Incompatible with strong oxidizing agents, phenol.

[ Water Solubility ]:
1 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QL2975000

CHEMICAL NAME :: 2-Naphthol

CAS REGISTRY NUMBER :: 135-19-3

LAST UPDATED :: 199710

DATA ITEMS CITED :: 30

MOLECULAR FORMULA :: C10-H8-O

MOLECULAR WEIGHT :: 144.18

WISWESSER LINE NOTATION :: L66J CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1960 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >770 mg/m3/1H

TOXIC EFFECTS :: Gastrointestinal - changes in structure or function of salivary glands

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2940 mg/kg

TOXIC EFFECTS :: Behavioral - sleep Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 97500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1335 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 2670 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10080 mg/kg/28D-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 107 mg/kg/35W-I

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Behavioral - alteration of classical conditioning

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1350 ug/m3/17W-I

TOXIC EFFECTS :: Blood - changes in erythrocyte (RBC) count Blood - changes in leukocyte (WBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other esterases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 298 mg/kg/35W-I

TOXIC EFFECTS :: Liver - liver function tests impaired

MUTATION DATA

TYPE OF TEST :: DNA repair

TEST SYSTEM :: Bacteria - Bacillus subtilis

DOSE/DURATION :: 5 gm/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 42,19,1977 *** REVIEWS *** TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 47,75,1978 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.1 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84296 No. of Facilities: 971 (estimated) No. of Industries: 18 No. of Occupations: 18 No. of Employees: 6346 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1957 No. of Facilities: 113 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 453 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84296 No. of Facilities: 199 (estimated) No. of Industries: 11 No. of Occupations: 26 No. of Employees: 10985 (estimated) No. of Female Employees: 590 (estimated)

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302 + H332-H400

[ Precautionary Statements ]:
P273

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R20/22;R50

[ Safety Phrases ]:
S24/25-S61

[ RIDADR ]:
UN 3077 9/PG 3

[ WGK Germany ]:
2

[ RTECS ]:
QL2975000

[ Packaging Group ]:
III

[ Hazard Class ]:
9

[ HS Code ]:
2907151000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

(2-Naphtyloxy)trimethylsilane
2-Bromonaphthalene
2-Naphthaleneboronic acid
naphthoic acid
2-prop-2-enoxynaphthalene
tert-butyl-dimethyl-naphthalen-2-yloxysilane
2-(4-methylphenyl)sulfonyloxynaphthalene
2-Methoxynaphthalene
1-Iodo-2-naphthol

DownStream

6-tert-butylnaphthalen-2-ol
1,6-Di-t-butyl-2-naphthol
naphthalen-2-yl prop-2-enoate
naphthalen-2-yl 3-chloropropanoate
O-2-Naphthyl chlorothioformate
(2-bromophenyl)methyl-(2-hydroxy-3-naphthalen-2-yloxypropyl)-dimethylazanium,bromide
3-amino-1-phenyl-1H-benzo[f]chromene-2-carbonitrile
1-[(2-methylpiperidin-1-yl)methyl]naphthalen-2-ol
3-amino-1-(2-chlorophenyl)-1H-benzo[f]chromene-2-carbonitrile
dl-1,1'-bi(2-naphthyl diacetate)

Customs

[ HS Code ]: 2907151000

[ Summary ]:
HS:2907151000 naphthalen-2-ol VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

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J. Chromatogr. A. 1350 , 102-11, (2014)

A high-performance TLC (HPTLC) method was newly developed and validated for analysis of 7 steviol glycosides in 6 different types of food and Stevia formulations. After a minimized one-step sample pre...

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QSAR study and synthesis of new phenyltropanes as ligands of the dopamine transporter (DAT).

Bioorg. Med. Chem. 20 , 1388-95, (2012)

The dopamine transporter (DAT) plays a pivotal role in the regulation of dopamine neurotransmission, and is involved in a number of physiological functions and brain disorders. Furthermore the DAT ana...

2-naphthol
2-Naphthol-d7
2-naphthol-d8
octyl-2-naphthol
3-BnO-2-naphthol
1-Iodo-2-naphthol
(3aS,4S,6aR)-Hexahydro-N-[6-[(2-mercaptoethyl)amino]-6-oxohexyl]-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanamide
Acetic acid, 2-(ethoxymethoxy)-, (1R,2R)-2-[(2,2-dichloroacetyl)amino]-3-hydroxy-1-(4-nitrophenyl)propyl ester
I+/--D-Glucopyranoside, methyl 3-O-methyl-4,6-O-(phenylmethylene)-, 2-[2,4,6-tris(1-methylethyl)benzenesulfonate]
1,4-Dihydro-4-oxo-1-phenyl-5H-pyrazolo[3,4-d]pyrimidine-5-acetic acid 2-(3-phenyl-2-propen-1-ylidene)hydrazide
4-[2-[4-[2-[4a(2)-(2-Benzoxazolyl)[1,1a(2)-biphenyl]-4-yl]diazenyl]-1-naphthalenyl]diazenyl]-N,N-dimethylbenzenamine
5,8-Methanopyrido[3,4-d]pyrimidine-7(6H)-carboxylic acid, 5,8-dihydro-2-(methylthio)-, 1,1-dimethylethyl ester
D-threo-Pentonic acid, 5-bromo-2,3,5-trideoxy-2-[[(1,1-dimethylethoxy)carbonyl]amino]-3,3-dimethyl-, I(3)-lactone
Pyrido[4,3-d][1,2,4]triazolo[1,5-a]pyrimidine-7(8H)-carboxylic acid, 9-chloro-5,6-dihydro-, phenylmethyl ester
4-Thiazolecarboxylic acid, 2-[1-[[(1,1-dimethylethoxy)carbonyl]amino]ethenyl]-4,5-dihydro-, ethyl ester, (R)-
N-[2-[(2S)-3-[[1-[(4-Chlorophenyl)methyl]-4-piperidinyl]amino]-2-hydroxy-2-methylpropoxy]phenyl]-Na(2)-ethylurea

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