N-Boc-cis-4-Hydroxy-D-proline

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Names

[ CAS No. ]:
135042-12-5

[ Name ]:
N-Boc-cis-4-Hydroxy-D-proline

[Synonym ]:
(2R,4R)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid
1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-dimethylethyl) ester, (2S,4S)-
N-Boc-cis-4-Hydroxy-D-proline
(4S)-4-Hydroxy-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline
(4R)-4-Hydroxy-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-D-proline
(2R,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
(2R,4R)-N-Boc-4-hydroxy-2-pyrrolidinecarboxylic acid
MFCD02094407
1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-dimethylethyl) ester, (2R,4R)-

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
390.9±42.0 °C at 760 mmHg

[ Melting Point ]:
145ºC

[ Molecular Formula ]:
C10H17NO5

[ Molecular Weight ]:
231.246

[ Flash Point ]:
190.2±27.9 °C

[ Exact Mass ]:
231.110672

[ PSA ]:
87.07000

[ LogP ]:
-0.71

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.531

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Di-tert-butyl dicarbonate
  • cis-4-Hydroxyproline
  • Carbonazidic acid,1,1-dimethylethyl ester
  • (4R)-4-Hydroxy-D-proline hydrochloride (1:1)
  • (2R,4R)-4-hydroxyproline-1,2-dicarboxylic acid 1-tert-butyl 2-ethyl ester
  • ethyl tert-butoxycarbonylamino(toluene-4-sulfonyl)acetate
  • ethyl (4R)-2-(N-tert-butyloxycarbonylamino)-5-tert-butyldimethylsiloxy-2-pentenoate
  • ethyl (4R)-N-tert-butyloxycarbonyl-4-tert-butyldiphenylsiloxy-α,β-didehydroprolinate
  • ethyl (R,Z)-2-((tert-butoxycarbonyl)amino)-4-((tert-butyldiphenylsilyl)oxy)-5-hydroxypent-2-enoate

DownStream

  • N-Boc-4-Oxo-D-proline
  • (2R,4R)-TERT-BUTYL 4-HYDROXY-2-(HYDROXYMETHYL)PYRROLIDINE-1-CARBOXYLATE
  • CIS-BOC-4-METHOXY-D-PROLINE
  • 1,2-PYRROLIDINEDICARBOXYLIC ACID, 4-METHOXY-, 1-(1,1-DIMETHYLETHYL) 2-METHYL ESTER, (2R,4R)-
  • [(2R,4R)-4-(2,6-diaminopurin-9-yl)pyrrolidin-2-yl]methanol
  • cis-4-Hydroxyproline
  • N-Boc-4-oxo-L-proline methyl ester
  • (2R,4S)-tert-Butyl 4-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • N-BOC-CIS-4-HYDROXY-D-PROLINE
  • N-Boc-cis-4-hydroxy-D-proline methyl ester
  • N-BOC-cis-4-Hydroxy-L-proline
  • N-Boc-cis-4-hydroxy-L-proline Methyl Ester
  • n-cbz-cis-4-hydroxy-d-proline methyl ester
  • Boc-D-Hyp-OtBu
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • Imidazo[1,2-a]pyridine-5,7-diamine,n5,n5,n7,n7-tetraethyl-
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide