(D-Arg0,Hyp3,D-Phe7,Leu8)-Bradykinin
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Names
[ CAS No. ]:
135701-67-6
[ Name ]:
(D-Arg0,Hyp3,D-Phe7,Leu8)-Bradykinin
[Synonym ]:
D-ARG-ARG-PRO-HYP-GLY-PHE-SER-D-PHE-LEU-ARG
L-Ornithine, N-(diaminomethylene)-D-ornithyl-N-(diaminomethylene)-L-ornithyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-L-phenylalanyl-L-seryl-D-phenylalanyl-L-leucyl-N-(diaminomethylene)-
Leu(8)]-bradykinin B2
D-Arg-L-Arg-L-Pro-L-t4Hyp-Gly-L-Phe-L-Ser-D-Phe-L-Leu-L-Arg-OH
D-ARG-[HYP3,D-PHE7,LEU8]-BRADYKININ
H-D-ARG-ARG-PRO-HYP-GLY-PHE-SER-D-PHE-LEU-ARG-OH
D-Arg(0)[Hyp(3),D-Phe(7),Leu(8)]-BK
D-Arg-L-Arg-L-Pro-4-Hydroxy-L-Pro-Gly-L-Phe-L-Ser-D-Phe-L-Leu-L-Arg-OH
Aaphgpspla
(D-ARG0,HYP3,D-PHE7,LEU8)-BRADYKININ
bradykinin,Arg-Hyp(3)-Phe(7)-Leu(8)
N-(Diaminomethylene)-D-ornithyl-N-(diaminomethylene)-L-ornithyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-L-phenylalanyl-L-seryl-D-phenylalanyl-L-leucyl-N-(diaminomethylene)-L-ornithine
D-Arg(0)[Hyp(3)
Chemical & Physical Properties
[ Density]:
1.5±0.1 g/cm3
[ Molecular Formula ]:
C57H89N19O13
[ Molecular Weight ]:
1248.436
[ Exact Mass ]:
1247.688721
[ PSA ]:
533.80000
[ LogP ]:
-1.49
[ Index of Refraction ]:
1.681
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ RIDADR ]:
NONH for all modes of transport
Synthetic Route
Articles
Agents Actions 34 , 138-141, (1991)
pA2 values of new B2 receptor antagonists ranging from 7.51 to 8.86 were measured on the rabbit jugular vein, while lower values were observed in the other preparations (for instance, the hamster urin...
Life Sci. 51 , PL 125, (1992)
Two new B1 receptor antagonists, [Hyp3,Thi5,DTic7,Oic8]desArg9-BK and DArg[Hyp3,Thi5,DTic7,Oic8]desArg9-BK were tested in vitro on the rabbit jugular vein and the guinea pig ileum (preparations contai...
J. Med. Chem. 35 , 1563, (1992)
A systematic study on the dimerization of the bradykinin (BK) antagonist D-Arg0-Arg1-Pro2-Hyp3-Gly4-Phe5-Ser6-D-Phe 7-Leu8-Arg9 has been performed. The first part of this study involved compounds wher...