(1R,2S)-1-Amino-2,3-dihydro-1H-inden-2-ol

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Names

[ CAS No. ]:
136030-00-7

[ Name ]:
(1R,2S)-1-Amino-2,3-dihydro-1H-inden-2-ol

[Synonym ]:
(1R,2S)-1-amino-2,3-dihydro-1H-inden-2-ol
(1R,2S)-1-Aminoindan-2-ol
MFCD00216656
(1R,2S)-(+)-cis-1-Amino-2-hydroxyindane
1H-Inden-2-ol, 1-amino-2,3-dihydro-, (1R,2S)-
(1R,2S)-(+)-1-Amino-2-indanol
(1R,2S)-(+)-1-Amino-2-hydroxyindan
(1R,2S)-(+)-cis-1-amino-2-indanol
(1R,2S)-1-Amino-2-indanol
Cis-(1R,2S)-1-amino-2-indanol

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
290.0±40.0 °C at 760 mmHg

[ Melting Point ]:
117-121ºC

[ Molecular Formula ]:
C9H11NO

[ Molecular Weight ]:
149.19

[ Flash Point ]:
129.2±27.3 °C

[ Exact Mass ]:
149.084061

[ PSA ]:
46.25000

[ LogP ]:
0.43

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.626

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R20/21/22;R36/37/38

[ Safety Phrases ]:
S26-S36/37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2922199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1-amino-2-hydroxyindane

DownStream

  • BIS((3AR,8AS)-8,8A-DIHYDRO-3AH-INDENO[1,2-D]OXAZOL-2-YL)METHANE
  • (1R,2R)-N-BOC-1-AMINO-2-INDANOL

Customs

[ HS Code ]: 2922199090

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

A series of potent HIV-1 protease inhibitors containing a hydroxyethyl secondary amine transition state isostere: synthesis, enzyme inhibition, and antiviral activity.

J. Med. Chem. 35 , 2525, (1992)

A series of HIV-1 protease inhibitors containing a novel hydroxyethyl secondary amine transition state isostere has been synthesized. The compounds exhibit a strong preference for the (R) stereochemis...

Synthesis and antiviral activity of a series of HIV-1 protease inhibitors with functionality tethered to the P1 or P1' phenyl substituents: X-ray crystal structure assisted design.

J. Med. Chem. 35 , 1685, (1992)

By tethering of a polar hydrophilic group to the P1 or P1' substituent of a Phe-based hydroxyethylene isostere, the antiviral potency of a series of HIV protease inhibitors was improved. The optimum e...

HIV-1 protease inhibitors based on hydroxyethylene dipeptide isosteres: an investigation into the role of the P1' side chain on structure-activity.

J. Med. Chem. 35 , 1702, (1992)

A systematic investigation was undertaken to determine the role of the P1' sidechain in a series of hydroxyethylene isostere based inhibitors of HIV-1 protease. Substitution and homologation of the be...


More Articles

Related Compounds

  • (1R,2S)-1-AMINO-2,3-DIHYDRO-1H-INDEN-2-OL
  • (1S,2S)-1-AMINO-2,3-DIHYDRO-1H-INDEN-2-OL
  • (1R,2S)-1-azido-2,3-dihydro-1H-inden-2-ol
  • (1R,2S)-1-(methylamino)-2,3-dihydro-1H-inden-2-ol
  • (1R,2S)-1-chloro-2,3-dihydro-1H-inden-2-ol
  • (1R,2R)-1-AMINO-2,3-DIHYDRO-1H-INDEN-2-OL