4-(bromomethyl)phenyl acetic acid

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Names

[ CAS No. ]:
13737-36-5

[ Name ]:
4-(bromomethyl)phenyl acetic acid

[Synonym ]:
4-(Carboxymethyl)benzyl Bromide
2-[4-(bromomethyl)phenyl]acetic acid
MFCD00010632
4-(BROMOMETHYL)PHENYLACETIC ACID
Benzeneacetic acid, 4-(bromomethyl)-
[4-(Bromomethyl)phenyl]acetic acid
4-(bromomethyl)phenyl acetic acid

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
343.1±22.0 °C at 760 mmHg

[ Melting Point ]:
179-183 °C(lit.)

[ Molecular Formula ]:
C9H9BrO2

[ Molecular Weight ]:
229.071

[ Flash Point ]:
161.3±22.3 °C

[ Exact Mass ]:
227.978592

[ PSA ]:
37.30000

[ LogP ]:
2.21

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.599

[ Storage condition ]:
Store at RT.

MSDS

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H315-H319-H334-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338-P342 + P311

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38;R42

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
UN3261

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2916399090

Synthetic Route

Precursor & DownStream

Precursor

  • Tolylacetic acid
  • Benzoyl peroxide
  • 2-(2-cyanopropan-2-yldiazenyl)-2-methylpropanenitrile

DownStream

  • Fmoc-(4-aminomethylphenyl)acetic acid
  • Diethyl 2-[4-(2,2-Dicarboethoxypropyl)phenyl]-2-methyl Malonate
  • methyl 2-[4-(cyanomethyl)phenyl]acetate
  • 2-(4-(METHOXYMETHYL)PHENYL)ACETIC ACID
  • methyl 2-(4-formylphenyl)acetate
  • 4-(2,2-Dicarboethoxy-propyl)phenylacetic Acid
  • 4-(2,2-Dicarboethoxy-propyl)phenylacetic Acid Ethyl Ester
  • 4-(hydroxymethyl)phenylacetic acid
  • Methyl [4-(bromomethyl)phenyl]acetate
  • 2-Oxo-2-phenylethyl 2-(4-(bromomethyl)phenyl)acetate

Customs

[ HS Code ]: 2916399090

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

J. Chem. Soc. Chem. Commun. , 399, (1993)

Effect of conformational mobility and hydrogen-bonding interactions on the selectivity of some guanidinoaryl-substituted mechanism-based inhibitors of trypsin-like serine proteases.

J. Med. Chem. 35 , 4297, (1992)

Previously, we have reported that some guanidino-substituted alpha- and beta-aryl enol lactones I and II behaved as selective, mechanism-based inhibitors of some trypsin-like proteases (Rai, R.; Katze...

Synthesis and anti-inflammatory activity of the major metabolites of imrecoxib.

Bioorg. Med. Chem. Lett. 19(8) , 2270-2, (2009)

We have developed a novel and moderately selective COX-2 inhibitor, imrecoxib, as a new anti-inflammatory drug. We describe herein the preparation of the major metabolites M2 and M4 of imrecoxib, as w...


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Related Compounds

  • [3-(Bromomethyl)phenyl]acetic acid
  • α-(4-bromomethylphenyl)acetic acid tert-butyl ester
  • Methyl [4-(bromomethyl)phenyl](cyclopentyl)acetic acid
  • benzyl 2-[4-(bromomethyl)phenyl]acetate
  • 2-[2-[4-(bromomethyl)phenyl]-1,3-thiazol-4-yl]acetic acid
  • N-(4-Bromomethylphenyl)acetamide