TYROTHRICIN
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Names
[ CAS No. ]:
1404-88-2
[ Name ]:
TYROTHRICIN
Chemical & Physical Properties
[ Density]:
1.32g/cm3
[ Boiling Point ]:
1516.6ºC at 760mmHg
[ Molecular Formula ]:
C65H85N11O13
[ Molecular Weight ]:
1228.44000
[ Flash Point ]:
871ºC
[ Exact Mass ]:
1227.63000
[ PSA ]:
379.75000
[ LogP ]:
5.10700
[ Vapour Pressure ]:
0mmHg at 25°C
[ Index of Refraction ]:
1.635
[ Water Solubility ]:
Practically insoluble in water, soluble in ethanol (96 per cent) and in methanol.
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- YP2975000
- CHEMICAL NAME :
- Tyrothricin
- CAS REGISTRY NUMBER :
- 1404-88-2
- LAST UPDATED :
- 199503
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >3 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >1500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1200 ug/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - excitement Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 20 mg/kg/10D-I
- TOXIC EFFECTS :
- Blood - changes in cell count (unspecified) Blood - changes in spleen Related to Chronic Data - death
MUTATION DATA
- TYPE OF TEST :
- DNA adduct
- TEST SYSTEM :
- Bacteria - Escherichia coli
- DOSE/DURATION :
- 25 umol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981 *** REVIEWS *** TOXICOLOGY REVIEW ADENAE Advances in Enzymology and Related Subjects of Biochemistry. (New York, NY) V.1-28, 1941-66. For publisher information, see AERAAD. Volume(issue)/page/year: 4,153,1944
Safety Information
[ Safety Phrases ]:
22-24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
2
[ RTECS ]:
YP2975000
Articles
Int. J. Clin. Pharmacol. Res. 8(4) , 259-61, (1988)
Three pharmaceutical preparations for the disinfection of the oropharynx were tested with regard to the gramicidin concentration obtained in the saliva after their appropriate application. Peak values...
Eur. J. Biochem. 170(1-2) , 253-8, (1987)
Using the [3H]trimethylpsoralen photobinding method [Sinden, R.R., Carlson, J.O. & Pettijohn, D.E. (1980) Cell 21, 773-783], a decrease in unrestrained torsional tension of DNA was detected in Bacillu...
Mycoses 39(1-2) , 45-50, (1996)
Tyrothricin, a polypeptide antibiotic, is active against yeast cells. Tyrothricin was rapidly fungicidal towards Candida albicans. Concentration of four times the minimum inhibitory (25 mg l-1) reduce...