Polymyxin B Sulfate
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Names
[ CAS No. ]:
1405-20-5
[ Name ]:
Polymyxin B Sulfate
[Synonym ]:
Octanamide, N-[3-amino-1-[[[1-[[[3-amino-1-[[[6,9,18-tris(2-aminoethyl)-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-15-(phenylmethyl)-1,4,7,10,13,16,19-heptaazacyclotricos-21-yl]amino]carbonyl]propyl]amino]carbonyl]-2-hydroxypropyl]amino]carbonyl]propyl]-6-methyl-, sulfate (1:1) (salt)
MASTIMYXIN
MYP SUPPLEMENT
N-[4-Amino-1-({1-[(4-amino-1-oxo-1-{[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-isobutyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]amino}-2-butanyl)amino]-3-hydroxy-1-oxo-2-butanyl}amino)-1-oxo-2-butanyl]-6-methyloctanamide sulfate (1:1)
APPLISORB
PolymyxineBsulfate
POLYMIXIN B SULPHATE
PolymyxinBSulfate(sterile,non-sterile)
N-[4-Amino-1-({1-[(4-amino-1-oxo-1-{[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-isobutyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]amino}-2-butanyl)amino]-3-hydroxy-1-oxo-2-butanyl}amino)-1-oxo-2-butanyl]-6-methyloctanamide sulfate (salt)
POLYMYXIN B
POLYMYXIN B (PMB)
POLYMIXIN B SULFATE
Polymyxin B Sulfate
AEROSPORIN
EINECS 215-774-7
octanimidic acid, N-[3-amino-1-[(Z)-[[1-[(E)-[[3-amino-1-[(E)-hydroxy[[(1Z,13E,19E)-6,9,18-tris(2-aminoethyl)-2,5,8,11,14,17,20-heptahydroxy-3-(1-hydroxyethyl)-12-(2-methylpropyl)-15-(phenylmethyl)-1,4,7,10,13,16,19-heptaazacyclotricosa-1,4,7,10,13,16,19-heptaen-21-yl]imino]methyl]propyl]imino]hydroxymethyl]-2-hydroxypropyl]imino]hydroxymethyl]propyl]-6-methyl-, (1E)-, sulfate (1:1) (salt)
MFCD00270609
Polymyxin B (Sulfate)
Chemical & Physical Properties
[ Boiling Point ]:
1651ºC at 760 mmHg
[ Melting Point ]:
217-220°C (dec.)
[ Molecular Formula ]:
C55H96N16O13.H2SO4(PolymyxinB2Sulfate)
[ Molecular Weight ]:
1287.53 (PolymyxinB2Sulfate)
[ Flash Point ]:
952.3ºC
[ PSA ]:
573.64000
[ LogP ]:
2.54990
[ Appearance of Characters ]:
powder
[ Vapour Pressure ]:
0mmHg at 25°C
[ Storage condition ]:
2-8°C
[ Water Solubility ]:
H2O: 50 mg/mL
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TR1150000
- CHEMICAL NAME :
- Polymyxin B sulfate
- CAS REGISTRY NUMBER :
- 1405-20-5
- LAST UPDATED :
- 199504
- DATA ITEMS CITED :
- 13
- MOLECULAR FORMULA :
- C43-H82-N16-O12.xH2-O4-S
- MOLECULAR WEIGHT :
- 1701.97
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 790 mg(base)/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 20500 ug(base)/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 59500 ug(base)/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5400 ug(base)/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 8 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intracerebral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 320 ug/kg
- TOXIC EFFECTS :
- Behavioral - coma
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 58 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Yeast - Saccharomyces cerevisiae
- DOSE/DURATION :
- 5 mg/L
- REFERENCE :
- AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972- Volume(issue)/page/year: 2,36,1972 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81938 No. of Facilities: 152 (estimated) No. of Industries: 4 No. of Occupations: 6 No. of Employees: 967 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9499 No. of Facilities: 383 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1149 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81938 No. of Facilities: 1842 (estimated) No. of Industries: 19 No. of Occupations: 18 No. of Employees: 173376 (estimated) No. of Female Employees: 145041 (estimated)
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302
[ Precautionary Statements ]:
P301 + P312 + P330
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn: Harmful;
[ Risk Phrases ]:
R22
[ Safety Phrases ]:
S22-S24/25
[ RIDADR ]:
3249
[ WGK Germany ]:
3
[ RTECS ]:
TR1150000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
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