EM20-25

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Names

[ CAS No. ]:
141266-44-6

[ Name ]:
EM20-25

[Synonym ]:
5-(2,4-dioxo-7-chloro-2,3,4,5-tetrahydro-1H-chromeno[2,3-d]pyrimidin-5-yl)pyrimidine-2,4,6(1H,3H,5H)-trione
1,5-Dihydro-7-chloro-5-<5'-pyrimidine-2',4',6'(1'H,3'H,5'H)-trionyl>-2H-chromeno<2,3-d>pyrimidine-2,4(1H,3H)-dione
EM20-25
Bcl-2 Inhibitor III,EM20-25
5-(6-Chloro-2,4-dioxo-1,3,4,10-tetrahydro-2H-9-oxa-1,3-diaza-anthracen-10-yl)-pyrimidine-2,4,6-trione
5-(7-chloro-2,4-dioxo-1,3-dihydro-5H-chromeno[2,3-d]pyrimidin-5-yl)-1,3,5-trih ydropyrimidine-2,4,6-trione

Chemical & Physical Properties

[ Molecular Formula ]:
C15H9ClN4O6

[ Molecular Weight ]:
376.70800

[ Exact Mass ]:
376.02100

[ PSA ]:
157.72000

[ LogP ]:
1.31280

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H400

[ Precautionary Statements ]:
P273

[ RIDADR ]:
UN 3077 9 / PGIII

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Barbituric acid
  • 5-Chloro-2-hydroxybenzaldehyde

DownStream

Articles

Use of human cancer cell lines mitochondria to explore the mechanisms of BH3 peptides and ABT-737-induced mitochondrial membrane permeabilization.

PLoS ONE 5(3) , e9924, (2010)

Current limitations of chemotherapy include toxicity on healthy tissues and multidrug resistance of malignant cells. A number of recent anti-cancer strategies aim at targeting the mitochondrial apopto...

The mitochondrial effects of small organic ligands of BCL-2: sensitization of BCL-2-overexpressing cells to apoptosis by a pyrimidine-2,4,6-trione derivative.

J. Biol. Chem. 281 , 10066-10072, (2006)

We have investigated the mitochondrial effects of BH3I-2', Chelerythrine, and HA14-1, small organic molecules that share the ability to bind the BH3 domain of BCL-2. All compounds displayed a biphasic...


More Articles

Related Compounds

  • 1,25,28-trihydroxyvitamin D 2
  • 3β,25-Epoxy-3-hydroxyurs-12-en-28-oic acid
  • (3S,5R)-3-[(E)-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]methyl]-1,3,4,5,6,7-hexahydro-2-benzofuran-1,5-diol
  • 1800104-25-9
  • 1,25-dihydroxy-previtamin D(3)
  • (10α)-25-Acetoxy-2α,3α,16α,20-tetrahydroxy-9β-methyl-19-norlanosta-5,23-diene-11,22-dione
  • 1-(1-(1H-Pyrazol-3-yl)ethyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid
  • 1-(4-Methoxyphenyl)-N-methyl-1-(1H-pyrrol-2-yl)methanamine
  • tert-Butyl (1-(4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)ethyl)carbamate
  • 2-(2-Carbamoyl-5-methylthiazol-4-yl)acetic acid
  • N-(2-Methyl-1-(1H-pyrazol-4-yl)propyl)pyridin-2-amine
  • N-(1-(5-(Furan-2-yl)-1H-pyrazol-3-yl)ethyl)butan-1-amine
  • N-(1-(1H-Pyrazol-4-yl)propyl)-3-methylpyridin-2-amine
  • 5-(1-(1H-Pyrazol-3-yl)ethyl)furan-2-carboxylic acid
  • N-((2,5-Dimethylfuran-3-yl)methyl)-1-(1H-pyrazol-4-yl)propan-1-amine
  • N-((2,5-Dimethylfuran-3-yl)methyl)-1-(1H-pyrazol-4-yl)ethanamine
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