Antibiotic 1142

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Names

[ CAS No. ]:
1438-30-8

[ Name ]:
Antibiotic 1142

[Synonym ]:
4-{4-[(N-carbamimidoyl-glycyl)-amino]-1-methyl-pyrrole-2-carbonylamino}-1-methyl-pyrrole-2-carboxylic acid-(2-carbamimidoyl-ethylamide)
t1384
Netropsin dihydrochloride
ia887
4-{4-[(N-Carbamimidoyl-glycyl)-amino]-1-methyl-pyrrol-2-carbonylamino}-1-methyl-pyrrol-2-carbonsaeure-(2-carbamimidoyl-aethylamid)
ch-777-a
Congocidin Sinanomycin
congocidin
ultrapuregrade
2814-a
antibiotic1142

Chemical & Physical Properties

[ Density]:
1.52g/cm3

[ Boiling Point ]:
544.74°C (rough estimate)

[ Melting Point ]:
171-173℃

[ Molecular Formula ]:
C18H26N10O3

[ Molecular Weight ]:
430.46400

[ Exact Mass ]:
430.21900

[ PSA ]:
208.93000

[ LogP ]:
1.62120

[ Appearance of Characters ]:
powder | faint yellow

[ Vapour Pressure ]:
1.75E-23mmHg at 25°C

[ Index of Refraction ]:
1.6500 (estimate)

[ Storage condition ]:
−20°C

[ Water Solubility ]:
H2O: 1 mg/mL

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DW2973000
CHEMICAL NAME :
N,4'-Bi(pyrrole-2-carboxamide), N'-(2-carbamoylethyl)-4-((2-guanidinoacetimidoyl)amin o)-1,1'- dimethyl-
CAS REGISTRY NUMBER :
1438-30-8
BEILSTEIN REFERENCE NO. :
0376913
LAST UPDATED :
199612
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C18-H26-N10-O3
MOLECULAR WEIGHT :
430.54
WISWESSER LINE NOTATION :
T5NJ A1 BVM2VZ EMV- BT5NJ A1 DMYUM&1MYZUM

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
70 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
17 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
DNA damage
TEST SYSTEM :
Mammal - species unspecified Lymphocyte
DOSE/DURATION :
500 umol/L
REFERENCE :
MLBRBU Molecular Biology Reports. (Dr. W. Junk Pub., POB 163, 3300 AD Dordrect, Netherlands) V.1- 1973- Volume(issue)/page/year: 2,135,1975

Safety Information

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S36

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
DW2973000

Related Compounds

  • Antibiotic 1142
  • 2-[3-(diaminomethylideneamino)-4-(3,4-dihydroxy-4,5-dimethyloxolan-2-yl)oxy-2,5,6-trihydroxycyclohexyl]guanidine
  • A201A
  • Antibiotic SF-973 A
  • Antibiotic TS 155-2
  • sodium,(5R,6R)-3-[(E)-2-acetamidoethenyl]sulfanyl-6-ethyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
  • 2-{1-[(3R)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-methylpentanoyl]piperidin-2-yl}acetic acid
  • 1-[(3R)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-methylpentanoyl]-4-methylpiperidine-3-carboxylic acid
  • 2-(3-{[2-(Tert-butoxy)-2-oxoethoxy]methyl}-4-methyl-5-(piperazin-1-yl)phenyl)acetic acid
  • (2S,3R)-2-[(3R)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-methylpentanamido]-3-methoxybutanoic acid
  • Methyl 5-{[2-(tert-butoxy)-2-oxoethoxy]methyl}-2-methyl-3-(piperazin-1-yl)benzoate
  • Methyl 3-{[2-(tert-butoxy)-2-oxoethoxy]methyl}-2-methyl-5-(piperazin-1-yl)benzoate
  • (1RS,2RS,4SR)-7-[(3R)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-methylpentanoyl]-7-azabicyclo[2.2.1]heptane-2-carboxylic acid
  • N-(1-cyano-1,2,2-trimethylpropyl)-1-[4-(trifluoromethyl)phenyl]-1H-pyrazole-4-carboxamide
  • (3R)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-{[(prop-2-en-1-yloxy)carbonyl]amino}butanoic acid
  • 1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-{[(prop-2-en-1-yloxy)carbonyl]amino}cyclobutane-1-carboxylic acid
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