Trihexylphenedyl
Suppliers
Names
[ CAS No. ]:
144-11-6
[ Name ]:
Trihexylphenedyl
[Synonym ]:
Parkinane retard
Trihexane
trihexyphenidyle
Artane
1-cyclohexyl-1-phenyl-3-piperidin-1-yl-propan-1-ol
trihexyphenidyl
Benzhexolum
Trihexifenidilo
EINECS 205-614-4
Cyclodol
Benzhexol
Triphenidyl
Chemical & Physical Properties
[ Density]:
1.04g/cm3
[ Boiling Point ]:
447.9ºC at 760 mmHg
[ Melting Point ]:
258.5ºC
[ Molecular Formula ]:
C20H31NO
[ Molecular Weight ]:
301.46600
[ Flash Point ]:
211ºC
[ Exact Mass ]:
301.24100
[ PSA ]:
23.47000
[ LogP ]:
4.26840
[ Vapour Pressure ]:
8.34E-09mmHg at 25°C
[ Index of Refraction ]:
1.546
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TN2620000
- CHEMICAL NAME :
- 1-Piperidinepropanol, alpha-cyclohexyl-alpha-phenyl-
- CAS REGISTRY NUMBER :
- 144-11-6
- BEILSTEIN REFERENCE NO. :
- 0088959
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C20-H31-N-O
- MOLECULAR WEIGHT :
- 301.52
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 335 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,1778,1970
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 150 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - excitement Behavioral - irritability
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 21,1727,1971
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 153 mg/kg
- TOXIC EFFECTS :
- Behavioral - ataxia Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 23,8,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 41 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 226,18,1955
Safety Information
[ HS Code ]:
2933399090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933399090
[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%