Iodoacetamide

Names

[ CAS No. ]:
144-48-9

[ Name ]:
Iodoacetamide

[Synonym ]:
MFCD00008028
carbamoylmethyl iodide
2-Iodo-acetamide
USAF D-1
Monoiodoacetamide
2-iodoacetamido
Acetamide, 2-iodo-
Iodoacetamide
ACETAMIDE,2-IODO
2-Iodoacetamide
Surauto
EINECS 205-630-1

Chemical & Physical Properties

[ Density]:
2.3±0.1 g/cm3

[ Boiling Point ]:
297.1±23.0 °C at 760 mmHg

[ Melting Point ]:
92-95 °C(lit.)

[ Molecular Formula ]:
C₂H₄INO

[ Molecular Weight ]:
184.964

[ Flash Point ]:
133.5±22.6 °C

[ Exact Mass ]:
184.933746

[ PSA ]:
43.09000

[ LogP ]:
-0.19

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.602

[ Storage condition ]:
2-8°C

[ Stability ]:
Stable, but light sensitive. Incompatible with strong oxidizing agents, strong bases, reducing agents, acids.

[ Water Solubility ]:
slightly soluble

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AC4200000

CHEMICAL NAME :: Acetamide, 2-iodo-

CAS REGISTRY NUMBER :: 144-48-9

BEILSTEIN REFERENCE NO. :: 1739080

LAST UPDATED :: 199701

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C2-H4-I-N-O

MOLECULAR WEIGHT :: 184.97

WISWESSER LINE NOTATION :: ZV1I

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 74 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1480 mg/kg/20W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 10 umol/L

REFERENCE :: STBIBN Studia Biophysica. (Akademie-Verlag GmbH, Postfach 1233, Berlin DDR-1086, Ger. Dem. Rep.) V.1- 1966- Volume(issue)/page/year: 50,97,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4435 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 28 (estimated)

Safety Information

[ Symbol ]:

GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H317-H334-H413

[ Precautionary Statements ]:
P261-P280-P301 + P310-P342 + P311

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T:Toxic;

[ Risk Phrases ]:
R25;R36/37/38;R43

[ Safety Phrases ]:
S22-S36/37-S45-S37/39-S26-S24

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
AC4200000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
2924199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

3,3-dimethyl-5'-oxo-1-ethyl-1,3-dihydrospiro[2H-indole-2,2'-pyrrolidine]
1-Ethyl-2,3,3-triMethylindolenium Iodide
thiodiacetic acid
Dithiodiglycolic acid
Hydrogen iodide
acetic acid
molecular iodine
Acetamide
(2-amino-2-oxoethyl) methanesulfonate
2,6-Piperidinedione,4-methyl-

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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