6-chloro-2-methyl-3-(3-methyl-1,2-oxazol-5-yl)quinazolin-4-one

Names

[ CAS No. ]:
144485-83-6

[ Name ]:
6-chloro-2-methyl-3-(3-methyl-1,2-oxazol-5-yl)quinazolin-4-one

Chemical & Physical Properties

[ Density]:
1.46g/cm3

[ Boiling Point ]:
487.5ºC at 760 mmHg

[ Molecular Formula ]:
C13H10ClN3O2

[ Molecular Weight ]:
275.69000

[ Flash Point ]:
248.6ºC

[ Exact Mass ]:
275.04600

[ PSA ]:
60.92000

[ LogP ]:
2.64390

[ Vapour Pressure ]:
1.18E-09mmHg at 25°C

[ Index of Refraction ]:
1.683

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VA2808000
CHEMICAL NAME :
4(3H)-Quinazolinone, 6-chloro-2-methyl-3-(3-methyl-5-isoxazolyl)-
CAS REGISTRY NUMBER :
144485-83-6
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C13-H10-Cl-N3-O2
MOLECULAR WEIGHT :
275.71

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
FRMCE8 Farmaco. (Societa Chimica Italiana, Corso Strada Nova, 86, Casella Postale 227, 27100 Pavia, Italy) V.44- 1989- Volume(issue)/page/year: 47,465,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
FRMCE8 Farmaco. (Societa Chimica Italiana, Corso Strada Nova, 86, Casella Postale 227, 27100 Pavia, Italy) V.44- 1989- Volume(issue)/page/year: 47,465,1992

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 5-Chloro-2-nitrobenzoyl chloride

DownStream

Related Compounds

  • (I+/-R)-I+/--(1-Methylethyl)-1H-pyrrolo[2,3-b]pyridine-5-methanamine
  • 1-(4,6-Diphenyl-1H-pyrrolo[2,3-B]pyridin-2-YL)ethanone
  • Ethyl 1-(3-aminophenyl)piperidine-2-carboxylate
  • 5-[(4-Fluorophenyl)methyl]-4-methyl-1,3-thiazol-2-amine
  • Methyl 3-aminopiperidine-2-carboxylate
  • N-(2,4-dimethoxyphenyl)-2-(3-(3,4-dimethoxyphenyl)-6-oxopyridazin-1(6H)-yl)acetamide
  • rel-tert-butyl(1R,3S,5S)-3-(2-ethoxy-2-oxoethyl)-8-azabicyclo[3.2.1]octane-8-carboxylate
  • (R)-tert-Butyl 4-(1-amino-2-methoxy-2-oxoethyl)piperidine-1-carboxylate
  • 2-[3-(4-bromophenyl)-6-oxo-1(6H)-pyridazinyl]-N~1~-(2-methoxyphenethyl)acetamide
  • 2-Nitro-5-[4-(trifluoromethyl)-1-piperidinyl]benzoic acid
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