6-chloro-3-(3-methyl-1,2-oxazol-5-yl)-2-phenylquinazolin-4-one

Names

[ CAS No. ]:
144485-85-8

[ Name ]:
6-chloro-3-(3-methyl-1,2-oxazol-5-yl)-2-phenylquinazolin-4-one

Chemical & Physical Properties

[ Density]:
1.4g/cm3

[ Boiling Point ]:
557.6ºC at 760mmHg

[ Molecular Formula ]:
C18H12ClN3O2

[ Molecular Weight ]:
337.76000

[ Flash Point ]:
291ºC

[ Exact Mass ]:
337.06200

[ PSA ]:
60.92000

[ LogP ]:
4.00250

[ Vapour Pressure ]:
1.81E-12mmHg at 25°C

[ Index of Refraction ]:
1.69

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VA2807000
CHEMICAL NAME :
4(3H)-Quinazolinone, 6-chloro-3-(3-methyl-5-isoxazolyl)-2-phenyl-
CAS REGISTRY NUMBER :
144485-85-8
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C18-H12-Cl-N3-O2
MOLECULAR WEIGHT :
337.78

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
FRMCE8 Farmaco. (Societa Chimica Italiana, Corso Strada Nova, 86, Casella Postale 227, 27100 Pavia, Italy) V.44- 1989- Volume(issue)/page/year: 47,465,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
FRMCE8 Farmaco. (Societa Chimica Italiana, Corso Strada Nova, 86, Casella Postale 227, 27100 Pavia, Italy) V.44- 1989- Volume(issue)/page/year: 47,465,1992

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 5-Chloro-2-nitrobenzoyl chloride

DownStream

Related Compounds

  • 1-cyclopropyl-1H,4H,6H,7H-pyrano[3,4-d]imidazole hydrochloride
  • (1-ethyl-5-fluoro-1H-pyrazol-4-yl)methanamine dihydrochloride
  • 1-Cyclopropyl-1,4,6,7-tetrahydropyrano[3,4-d]imidazol-2-amine hydrochloride
  • 6-Amino-N-(3-ethoxyphenyl)pyridine-2-carboxamide;hydrochloride
  • {3-Bromoimidazo[1,2-a]pyridin-2-yl}methanamine hydrochloride
  • 2-Cycloheptylazetidine hydrochloride
  • Lithium(1+) ion 5-(tert-butoxy)-4-hydroxy-5-oxopentanoate
  • 5-{[(9H-fluoren-9-yl)methoxy]carbonyl}-3H,4H,5H,6H,7H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrochloride
  • (5-bromo-1-methyl-1H-pyrazol-3-yl)methanamine hydrochloride
  • (2R)-N-[4-(1H-Benzimidazol-2-yl)phenyl]piperidine-2-carboxamide;hydrochloride
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