6-chloro-3-(3-methyl-1,2-oxazol-5-yl)-2-phenylquinazolin-4-one

Names

[ CAS No. ]:
144485-85-8

[ Name ]:
6-chloro-3-(3-methyl-1,2-oxazol-5-yl)-2-phenylquinazolin-4-one

Chemical & Physical Properties

[ Density]:
1.4g/cm3

[ Boiling Point ]:
557.6ºC at 760mmHg

[ Molecular Formula ]:
C18H12ClN3O2

[ Molecular Weight ]:
337.76000

[ Flash Point ]:
291ºC

[ Exact Mass ]:
337.06200

[ PSA ]:
60.92000

[ LogP ]:
4.00250

[ Vapour Pressure ]:
1.81E-12mmHg at 25°C

[ Index of Refraction ]:
1.69

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VA2807000
CHEMICAL NAME :
4(3H)-Quinazolinone, 6-chloro-3-(3-methyl-5-isoxazolyl)-2-phenyl-
CAS REGISTRY NUMBER :
144485-85-8
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C18-H12-Cl-N3-O2
MOLECULAR WEIGHT :
337.78

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
FRMCE8 Farmaco. (Societa Chimica Italiana, Corso Strada Nova, 86, Casella Postale 227, 27100 Pavia, Italy) V.44- 1989- Volume(issue)/page/year: 47,465,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
FRMCE8 Farmaco. (Societa Chimica Italiana, Corso Strada Nova, 86, Casella Postale 227, 27100 Pavia, Italy) V.44- 1989- Volume(issue)/page/year: 47,465,1992

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 5-Chloro-2-nitrobenzoyl chloride

DownStream

Related Compounds

  • N-(2-bromophenyl)-2-[(2-ethylquinazolin-4-yl)oxy]acetamide
  • N-(3-bromophenyl)-2-[(2-ethylquinazolin-4-yl)oxy]acetamide
  • N-(4-chloro-2-fluorophenyl)-2-[(2-ethylquinazolin-4-yl)oxy]acetamide
  • 1-{4-[(2-chlorobenzoyl)amino]phenyl}-N-cyclopentyl-2-oxo-1,2-dihydropyridine-3-carboxamide
  • N-(4-bromo-2-fluorophenyl)-2-[(2-ethylquinazolin-4-yl)oxy]acetamide
  • 2-[(2-ethylquinazolin-4-yl)oxy]-N-[2-(trifluoromethyl)phenyl]acetamide
  • N-(2-chloro-4-methylphenyl)-2-[(2-ethylquinazolin-4-yl)oxy]acetamide
  • 4-amino-N3-ethyl-N5-(4-(methylthio)benzyl)isothiazole-3,5-dicarboxamide
  • 4-amino-N5-[(2,5-dimethoxyphenyl)methyl]-N3-ethyl-1,2-thiazole-3,5-dicarboxamide
  • 4-amino-N3-ethyl-N5-(2-(trifluoromethyl)benzyl)isothiazole-3,5-dicarboxamide
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