Resiquimod

Suppliers

Names

[ Name ]:
Resiquimod

[Synonym ]:
1-[4-Amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methyl-2-propanol
1H-imidazo[4,5-c]quinoline-1-ethanol, 4-amino-2-(ethoxymethyl)-α,α-dimethyl-
Resiquimod
1-[4-amino-2-(ethoxymethyl)imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol
1-(4-Amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol
4-amino-2-(ethoxymethyl)-a,a-dimethyl-1h-imidazo[4,5-c]quinoline-1-ethanol
1-[4-Amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol
R848

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
553.6±50.0 °C at 760 mmHg

[ Melting Point ]:
193 °C

[ Molecular Formula ]:
C₁₇H₂₂N₄O₂

[ Molecular Weight ]:
314.382

[ Flash Point ]:
288.6±30.1 °C

[ Exact Mass ]:
314.174286

[ PSA ]:
86.19000

[ LogP ]:
2.15

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.635

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
NJ5911320

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

N-{2-chloro-4-[(2-hydroxy-2-methylpropyl)amino]quinolin-3-yl}-2-ethoxyacetamide
Carbon
1-[(2-chloro-3-nitro-4-quinolinyl)amino]-2-methyl-2-propanol
1-[(3-amino-2-chloroquinolin-4-yl)amino]-2-methylpropan-2-ol
4-hydroxy-3-nitro-1H-quinolin-2-one
quinoline-2,4-diol
2,4-DICHLORO-3-NITRO-QUINOLINE

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Mucolipin 1 positively regulates TLR7 responses in dendritic cells by facilitating RNA transportation to lysosomes.

Int. Immunol. 27(2) , 83-94, (2015)

Toll-like receptor 7 (TLR7) and TLR9 sense microbial single-stranded RNA (ssRNA) and ssDNA in endolysosomes. Nucleic acid (NA)-sensing in endolysosomes is thought to be important for avoiding TLR7/9 r...

Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases.

Nat. Commun. 6 , 6119, (2015)

Toll-like receptor 7 (TLR7) senses microbial-derived RNA but can also potentially respond to self-derived RNA. To prevent autoimmune responses, TLR7 is thought to localize in endolysosomes. Contrary t...

Targeting antigens through blood dendritic cell antigen 2 on plasmacytoid dendritic cells promotes immunologic tolerance.

J. Immunol. 192(12) , 5789-801, (2014)

The C-type lectin receptor blood dendritic cell Ag 2 (BDCA2) is expressed exclusively on human plasmacytoid DCs (pDCs) and plays a role in Ag capture, internalization, and presentation to T cells. We ...

Resiquimod-d5
tert-butyl N-{5-[(3S)-3-hydroxybutyl]-4-methyl-1,3-thiazol-2-yl}carbamate
1-[(1S,5S)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl]-3,3-difluorocyclobutan-1-amine
Phenol, 3-(chloromethyl)-4-methoxy-, 1-benzoate
(1-{Bicyclo[2.2.1]heptan-2-yl}-4,4-difluorocyclohexyl)methanamine
2-Methoxy-2-(3-methyloxetan-3-yl)propan-1-amine
[3,3-Difluoro-1-(1,1,2,2-tetrafluoroethyl)cyclobutyl]methanamine
1-(Cyclopentylmethyl)-3,3-difluorocyclobutan-1-amine
4-(Acetyl-D3)benzoic acid
2,2-Difluoro-1-(2,2,3,3,3-pentafluoropropyl)cyclopropan-1-amine
2,2-Difluoro-1-(fluoromethyl)cyclopropan-1-amine

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