Resiquimod
Resiquimod structure
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Common Name | Resiquimod | ||
|---|---|---|---|---|
| CAS Number | 144875-48-9 | Molecular Weight | 314.382 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 553.6±50.0 °C at 760 mmHg | |
| Molecular Formula | C17H22N4O2 | Melting Point | 193 °C | |
| MSDS | Chinese USA | Flash Point | 288.6±30.1 °C | |
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Mucolipin 1 positively regulates TLR7 responses in dendritic cells by facilitating RNA transportation to lysosomes.
Int. Immunol. 27(2) , 83-94, (2015) Toll-like receptor 7 (TLR7) and TLR9 sense microbial single-stranded RNA (ssRNA) and ssDNA in endolysosomes. Nucleic acid (NA)-sensing in endolysosomes is thought to be important for avoiding TLR7/9 responses to self-derived NAs. Aberrant self-derived NA tran... |
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Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases.
Nat. Commun. 6 , 6119, (2015) Toll-like receptor 7 (TLR7) senses microbial-derived RNA but can also potentially respond to self-derived RNA. To prevent autoimmune responses, TLR7 is thought to localize in endolysosomes. Contrary to this view, we show here that TLR7 is present on the cell ... |
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Targeting antigens through blood dendritic cell antigen 2 on plasmacytoid dendritic cells promotes immunologic tolerance.
J. Immunol. 192(12) , 5789-801, (2014) The C-type lectin receptor blood dendritic cell Ag 2 (BDCA2) is expressed exclusively on human plasmacytoid DCs (pDCs) and plays a role in Ag capture, internalization, and presentation to T cells. We used transgenic mice that express human BDCA2 and anti-BDCA... |
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Required role of apoptotic myogenic precursors and toll-like receptor stimulation for the establishment of autoimmune myositis in experimental murine models.
Arthritis Rheumatology 67(3) , 809-22, (2015) Muscle regeneration is a hallmark of the idiopathic inflammatory myopathies (IIMs), a group of autoimmune disorders that are characterized by leukocyte infiltration and dysfunction of the skeletal muscle. Despite detailed studies describing the clinical and h... |
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Interleukin-22 is increased in multiple sclerosis patients and targets astrocytes.
J. Neuroinflammation 12 , 119, (2015) Increasing evidences link T helper 17 (Th17) cells with multiple sclerosis (MS). In this context, interleukin-22 (IL-22), a Th17-linked cytokine, has been implicated in blood brain barrier breakdown and lymphocyte infiltration. Furthermore, polymorphism betwe... |
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Activated NKT Cells Can Condition Different Splenic Dendritic Cell Subsets To Respond More Effectively to TLR Engagement and Enhance Cross-Priming.
J. Immunol. 195 , 821-31, (2015) The function of dendritic cells (DCs) can be modulated through multiple signals, including recognition of pathogen-associated molecular patterns, as well as signals provided by rapidly activated leukocytes in the local environment, such as innate-like T cells... |
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No evidence of pathogenic involvement of cathelicidins in patient cohorts and mouse models of lupus and arthritis.
PLoS ONE 9(12) , e115474, (2014) Apart from their role in the immune defence against pathogens evidence of a role of antimicrobial peptides (AMPs) in autoimmune diseases has accumulated in the past years. The aim of this project was to examine the functional impact of the human cathelicidin ... |
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B cell TLR1/2, TLR4, TLR7 and TLR9 interact in induction of class switch DNA recombination: modulation by BCR and CD40, and relevance to T-independent antibody responses.
Autoimmunity 48(1) , 1-12, (2014) Ig class switch DNA recombination (CSR) in B cells is crucial to the maturation of antibody responses. It requires IgH germline IH-CH transcription and expression of AID, both of which are induced by engagement of CD40 or dual engagement of a Toll-like recept... |
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B cell Rab7 mediates induction of activation-induced cytidine deaminase expression and class-switching in T-dependent and T-independent antibody responses.
J. Immunol. 194(7) , 3065-78, (2015) Class switch DNA recombination (CSR) is central to the maturation of the Ab response because it diversifies Ab effector functions. Like somatic hypermutation, CSR requires activation-induced cytidine deaminase (AID), whose expression is restricted to B cells,... |
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Innate immune response to Streptococcus pyogenes depends on the combined activation of TLR13 and TLR2.
PLoS ONE 10(3) , e0119727, (2015) Innate immune recognition of the major human-specific Gram-positive pathogen Streptococcus pyogenes is not understood. Here we show that mice employ Toll-like receptor (TLR) 2- and TLR13-mediated recognition of S. pyogenes. These TLR pathways are non-redundan... |