3-Methylpyrazole

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Names

[ CAS No. ]:
1453-58-3

[ Name ]:
3-Methylpyrazole

[Synonym ]:
3-Methyl-1H-pyrazole
EINECS 215-925-7
3-methyl-pyrazole
methyl pyrazol-
1H-Pyrazole, 3-methyl-
5-Methylpyrazole
3-Methyl-1,2-diazole
3-Methylpyrazole
Pyrazole,5-methyl
Pyrazole,3-methyl
3-(5)-methylpyrazole
3-methyl-pyrazol
pyrazolylmethane
MFCD00005240
5-methyl-pyrazol

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
204.0±0.0 °C at 760 mmHg

[ Melting Point ]:
36 - 37ºC

[ Molecular Formula ]:
C4H6N2

[ Molecular Weight ]:
82.104

[ Flash Point ]:
87.4±11.7 °C

[ Exact Mass ]:
82.053101

[ PSA ]:
28.68000

[ LogP ]:
0.78

[ Vapour Pressure ]:
0.4±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.523

[ Storage condition ]:
Refrigerator

[ Water Solubility ]:
miscible

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UQ7340000
CHEMICAL NAME :
Pyrazole, 3-methyl-
CAS REGISTRY NUMBER :
1453-58-3
BEILSTEIN REFERENCE NO. :
0001454
LAST UPDATED :
199710
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C4-H6-N2
MOLECULAR WEIGHT :
82.12
WISWESSER LINE NOTATION :
T5MNJ C1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
710 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - somnolence (general depressed activity) Cardiac - other changes
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 32(9),50,1988
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
719 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 32(9),50,1988
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
240 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - excitement Behavioral - ataxia
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(6),29,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 25,27,1962

Safety Information

[ Symbol ]:

GHS05, GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H314-H361

[ Precautionary Statements ]:
P201-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338-P308 + P313

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26-S36-S24/25

[ RIDADR ]:
2810

[ WGK Germany ]:
3

[ RTECS ]:
UQ7340000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
29331990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • dichloroethane
  • 4,4-Dimethoxy-2-butanone
  • Diacetylene
  • 1,4-Dichlorbut-2-in
  • 5-methyl-2-pyrazoline
  • 1-(PYRROLIDIN-1-YLMETHYL)-1H-PYRAZOLE
  • methyl iodide

DownStream

  • 3-Methyl-1H-pyrazole-4-boronic acid pinacol ester
  • TERT-BUTYL 3-METHYL-1H-PYRAZOLE-1-CARBOXYLATE
  • 1-(4-Chlorophenyl)-3-methyl-1H-pyrazole
  • 3-methylpyrazole-1-carboxamide
  • 3-Methyl-4-nitro-1H-pyrazole
  • 1,3-Dimethylpyrazole
  • 1,5-Dimethylpyrazole
  • 3-methyl-1-phenylpyrazole
  • 5-METHYL-1-PHENYL-1H-PYRAZOLE
  • 4-Nitro-1H-pyrazole-3-carboxylic acid

Customs

[ HS Code ]: 2933199090

[ Summary ]:
2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

[Toxicological evaluation of a new nitrification inhibitor and its metabolite].

Gig. Sanit. (6) , 29-31, (1986)

Differential effects of 4-iodopyrazole and 3-methylpyrazole on the metabolic activation of methylazoxymethanol to a DNA methylating species by rat liver and rat colon mucosa in vivo.

J. Cancer Res. Clin. Oncol. 113(2) , 145-50, (1987)

Using a hybrid ion-exchange reverse phase HPLC system, we found that F344 rat liver microsomes, in the presence of an NADPH-generating system, can metabolize methylazoxymethanol (MAM), a colon and liv...

Extremely long protection by pyrazole derivatives against chemically induced gastric mucosal injury.

J. Pharmacol. Exp. Ther. 256(2) , 592-8, (1991)

We tested the hypothesis that the gastrotoxicity of ethanol and other damaging agents is influenced through the modulation of alcohol dehydrogenase (ADH) by using either the ADH-inhibitor pyrazole or ...


More Articles

Related Compounds

  • 3-Methylpyrazole
  • 4-Iodo-3-methylpyrazole
  • 4-Bromo-3-methylpyrazole
  • 1-ethyl-3-methylpyrazole
  • 1-vinyl-3-methylpyrazole
  • 5-amino-3-methylpyrazole
  • 2-[2-[3-[(6-Methylpyridin-2-yl)oxymethyl]piperidin-1-yl]-2-oxoethyl]pyridazin-3-one
  • 2-(Pyridin-3-yl)-1-{3-[(pyridin-3-yloxy)methyl]azetidin-1-yl}ethan-1-one
  • 4-[3-[(5-Bromopyrimidin-2-yl)oxymethyl]piperidin-1-yl]-2,6-dimethylpyrimidine
  • 6-Methyl-3-[2-(4-{[(3-methylpyridin-2-yl)oxy]methyl}piperidin-1-yl)-2-oxoethyl]-3,4-dihydropyrimidin-4-one
  • 2-[[1-(1-Methyltriazole-4-carbonyl)piperidin-4-yl]methoxy]pyridine-4-carbonitrile
  • 4-Ethyl-5-fluoro-6-(3-{[(6-methylpyridin-2-yl)oxy]methyl}piperidin-1-yl)pyrimidine
  • 2-Pyridin-3-yl-1-[4-(pyrimidin-2-yloxymethyl)piperidin-1-yl]ethanone
  • 2-{[1-(Cyclopropanesulfonyl)piperidin-3-yl]methoxy}-6-methylpyridine
  • (1,5-Dimethylpyrazol-3-yl)-[3-[(5-methylpyrimidin-2-yl)oxymethyl]piperidin-1-yl]methanone
  • 3-{[1-(3-methoxy-1-methyl-1H-pyrazole-4-carbonyl)azetidin-3-yl]methoxy}pyridine
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