3-Methylpyrazole

Modify Date: 2025-08-23 20:18:57

3-Methylpyrazole structure	Common Name	3-Methylpyrazole
	CAS Number	1453-58-3	Molecular Weight	82.104
	Density	1.1±0.1 g/cm3	Boiling Point	204.0±0.0 °C at 760 mmHg
	Molecular Formula	C₄H₆N₂	Melting Point	36 - 37ºC
	MSDS	Chinese USA	Flash Point	87.4±11.7 °C
	Symbol	GHS05, GHS07, GHS08	Signal Word	Danger

Use of 3-Methylpyrazole

3-Methylpyrazole is used as a nitrification inhibitor of nitrification in soil[1].

Name	3-Methylpyrazole
Synonym	More Synonyms

Description	3-Methylpyrazole is used as a nitrification inhibitor of nitrification in soil[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vitro	3-Methylpyrazole could inhibit the metabolism of MAM by rat liver microsomes[2].
References	[1]. G.W. McCarty, et al. Inhibition of nitrification in soil by heterocyclic nitrogen compounds. Biol Fertil Soils (1989) 8:204-211. [2]. Fiala ES, et al. Differential effects of 4-iodopyrazole and 3-methylpyrazole on the metabolic activation of methylazoxymethanol to a DNA methylating species by rat liver and rat colon mucosa in vivo. J Cancer Res Clin Oncol. 1987;113(2):145-50.

Density	1.1±0.1 g/cm3
Boiling Point	204.0±0.0 °C at 760 mmHg
Melting Point	36 - 37ºC
Molecular Formula	C₄H₆N₂
Molecular Weight	82.104
Flash Point	87.4±11.7 °C
Exact Mass	82.053101
PSA	28.68000
LogP	0.78
Vapour Pressure	0.4±0.3 mmHg at 25°C
Index of Refraction	1.523
Storage condition	Refrigerator
Water Solubility	miscible

3-Methylpyrazole MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ7340000

CHEMICAL NAME :: Pyrazole, 3-methyl-

CAS REGISTRY NUMBER :: 1453-58-3

BEILSTEIN REFERENCE NO. :: 0001454

LAST UPDATED :: 199710

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C4-H6-N2

MOLECULAR WEIGHT :: 82.12

WISWESSER LINE NOTATION :: T5MNJ C1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 710 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - somnolence (general depressed activity) Cardiac - other changes

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 32(9),50,1988

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 719 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 32(9),50,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 240 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - excitement Behavioral - ataxia

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(6),29,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 25,27,1962

Symbol	GHS05, GHS07, GHS08
Signal Word	Danger
Hazard Statements	H302-H314-H361
Precautionary Statements	P201-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338-P308 + P313
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xn:Harmful
Risk Phrases	R22;R36/37/38
Safety Phrases	S26-S36-S24/25
RIDADR	2810
WGK Germany	3
RTECS	UQ7340000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	29331990

Precursor 7
CAS#:107-06-2 dichloroethane CAS#:5436-21-5 4,4-Dimethoxy-2... CAS#:460-12-8 Diacetylene CAS#:821-10-3 1,4-Dichlorbut-2-in
CAS#:1568-20-3 5-methyl-2-pyra... CAS#:91272-98-9 1-(PYRROLIDIN-1... CAS#:74-88-4 methyl iodide
DownStream 10
CAS#:936250-20-3 3-Methyl-1H-pyr... CAS#:186551-70-2 TERT-BUTYL 3-ME... CAS#:27301-77-5 1-(4-Chlorophen... CAS#:873-50-7 3-methylpyrazol...
CAS#:5334-39-4 3-Methyl-4-nitr... CAS#:694-48-4 1,3-Dimethylpyrazole CAS#:694-31-5 1,5-Dimethylpyrazole CAS#:1128-54-7 3-methyl-1-phen...
CAS#:6831-91-0 5-METHYL-1-PHEN... CAS#:5334-40-7 4-Nitro-1H-pyra...

HS Code	2933199090
Summary	2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

[Toxicological evaluation of a new nitrification inhibitor and its metabolite].

Gig. Sanit. (6) , 29-31, (1986)

Differential effects of 4-iodopyrazole and 3-methylpyrazole on the metabolic activation of methylazoxymethanol to a DNA methylating species by rat liver and rat colon mucosa in vivo.

J. Cancer Res. Clin. Oncol. 113(2) , 145-50, (1987)

Using a hybrid ion-exchange reverse phase HPLC system, we found that F344 rat liver microsomes, in the presence of an NADPH-generating system, can metabolize methylazoxymethanol (MAM), a colon and liv...

Extremely long protection by pyrazole derivatives against chemically induced gastric mucosal injury.

J. Pharmacol. Exp. Ther. 256(2) , 592-8, (1991)

We tested the hypothesis that the gastrotoxicity of ethanol and other damaging agents is influenced through the modulation of alcohol dehydrogenase (ADH) by using either the ADH-inhibitor pyrazole or ...

3-Methyl-1H-pyrazole

EINECS 215-925-7

3-methyl-pyrazole

methyl pyrazol-

1H-Pyrazole, 3-methyl-

5-Methylpyrazole

3-Methyl-1,2-diazole

3-Methylpyrazole

Pyrazole,5-methyl

Pyrazole,3-methyl

3-(5)-methylpyrazole

3-methyl-pyrazol

pyrazolylmethane

MFCD00005240

5-methyl-pyrazol

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