Isonicotinamide

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Names

[ CAS No. ]:
1453-82-3

[ Name ]:
Isonicotinamide

[Synonym ]:
4-Pyridine carboxamide
MFCD00006432
4-pyridinecarboximidic acid
4-Pyridinecarboxamide
EINECS 215-926-2
4-(HYDROXYIMINOMETHYL)PYRIDINE
Isonicotinamide
Pyridine-4-carboximidic acid
pyridine-4-carboxamide

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
334.4±15.0 °C at 760 mmHg

[ Melting Point ]:
155-157 °C(lit.)

[ Molecular Formula ]:
C6H6N2O

[ Molecular Weight ]:
122.13

[ Flash Point ]:
156.0±20.4 °C

[ Exact Mass ]:
122.048012

[ PSA ]:
55.98000

[ LogP ]:
-0.28

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.570

[ Water Solubility ]:
191.7 g/L (37 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NR9500000
CHEMICAL NAME :
Isonicotinamide
CAS REGISTRY NUMBER :
1453-82-3
BEILSTEIN REFERENCE NO. :
0002173
LAST UPDATED :
199701
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C6-H6-N2-O
MOLECULAR WEIGHT :
122.14
WISWESSER LINE NOTATION :
T6NJ DVZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Rodent - rat Liver
DOSE/DURATION :
20 mmol/L
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 69,1353,1982

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
NR9500000

[ HS Code ]:
29333999

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Isonicotinonitrile
  • 4-picolinylamine
  • 4-Cyanopyridinium-1-olate
  • benzotriazol-1-yl(pyridin-4-yl)methanone
  • 4-Pyridinealdoxime
  • Isonicotinamide 1-oxide
  • 4-Pyridinemethanol
  • 4-Vinylpyridine
  • 4-Pyridinecarbothioamide
  • Isonicotinic acid

DownStream

  • Isonicotinic acid
  • Isoniazid
  • 2-Chloro-4-cyanopyridine
  • Isonicotinamide 1-oxide
  • Piperidine-4-carboxamide
  • 4-picolinylamine
  • p-Formylpyridine
  • 4-Pyridinemethanol
  • 4-Picoline
  • piconol

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Related Compounds

  • isonicotinamide
  • isonicotinamide
  • Isonicotinamide
  • Isonicotinamide-d4
  • Thioisonicotinamide
  • Isonicotinamide oxime
  • tert-butyl N-[2-amino-2-(3-bromo-5-methylphenyl)ethyl]carbamate
  • 4-(1-Phenylprop-1-en-2-yl)oxane-4-carboxylic acid
  • tert-butyl N-[4-chloro-2-(morpholin-2-yl)phenyl]carbamate
  • tert-butyl N-[4-chloro-2-(1-hydroxycyclopropyl)phenyl]carbamate
  • tert-butyl N-[2-amino-2-(6-methylpyridin-3-yl)ethyl]carbamate
  • tert-butyl N-[2-amino-2-(3-ethoxy-4-hydroxyphenyl)ethyl]carbamate
  • tert-butyl N-{5-[(1R)-3-amino-1-hydroxypropyl]-2-methylphenyl}carbamate
  • 1-[(3-{[(Tert-butoxy)carbonyl]amino}-4-methylphenyl)methyl]cyclopropane-1-carboxylic acid
  • tert-butyl N-{5-[2-(1-aminocyclopropyl)ethyl]-2-methylphenyl}carbamate
  • tert-butyl N-[5-(3-hydroxybutyl)-2-methylphenyl]carbamate
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